Articles tagged "Ischemia"

2020 American Transplant Congress
Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers
I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
J. Li, N. Rogers, S. Alexander
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
2020 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury
J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2020 American Transplant Congress
Metabolism Reprogramming During Conventional versus Ischemia-Free Liver Transplantation
Z. Guo¹, Z. Zhang¹, N. Gao¹, H. Zhang², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: Our group has developed a novel transplant procedure called ischemia-free liver transplantation (IFLT), during which the liver can be procured, preserved and implanted without…
2020 American Transplant Congress
Rouleaux Formation in Human Livers During Normothermic Machine Perfusion
M. Harris¹, S. Raigani², C. Albert³, M. Reschke³, C. Carroll², J. T. Langford¹, C. Edwards⁴, D. Mulligan⁴, D. Haakinson¹, K. Uygun², H. Yeh², G. Tietjen¹
¹Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, ²Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Yale School of Engineering and Applied Science, New Haven, CT, ⁴Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT
*Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…
2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, S. Kageyama¹, K. Nakamura¹, H. Hirao¹, H. Kojima¹, T. Ito¹, K. J. Dery¹, X. Li², R. W. Busuttil¹, F. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
J. Lee¹, K. Sjöholm², C. Kjellman², T. Lorant², L. Winstedt², V. Nigro², K. M. Roupé², Å. Schiött², A. Runstrom², S. Taranto³, T. Baker³, D. Stewart³
¹Medical Affairs, Hansa Biopharma, Camas, WA, ²Hansa Biopharma, Lund, Sweden, ³UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
2020 American Transplant Congress
Paired-Donor Kidney Exchange Has Comparable Early Graft Function to Directed Living Donor
E. McCracken, A. Sites, B. Rawashdeh, A. Nishio-Lucar, A. Agarwal
Transplant Surgery, University of Virginia, Charlottesville, VA
*Purpose: Living kidney donation in the United States is associated with improved graft and patient survival. However, there is minimal data on graft function in…
2020 American Transplant Congress
Experimental Porcine Pancreatic Allotransplantation after Hypothermic Perfusion
T. Prudhomme¹, D. Kervella¹, K. Renaudin², V. Gauttier¹, S. Le Bas-Bernardet³, D. Minault³, J. Hervouet³, D. Cantarovich¹, G. Karam¹, G. Blancho¹, J. Branchereau¹
¹Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France, ²Département d’Anatomie et de Cytologie Pathologique, CHU Nantes, Nantes, France, ³Centre de Recherche en Transplantation et Immunologie, UMR1064, INSERM, Université de Nantes, Nantes, France
*Purpose: The main objective of this study was to compare the different preservation techniques (static cold storage (SCS) and hypothermic pulsatile perfusion (HPP)) in a…
2020 American Transplant Congress
Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², Y. Guo², B. Oh², G. Brandacher², J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…