Articles tagged "Ischemia"

2020 American Transplant Congress
Increased Mitochondrial Metabolic Enzymes are Associated with Superior Kidney Function after Normothermic Ex-Vivo Kidney Perfusion-A Proteomics Study
C. McEvoy¹, S. Clotet-Freixas¹, T. Tokar², C. Pastrello², S. Reid³, I. Batruch⁴, A. RaoPeters⁵, P. Urbanellis¹, M. Kaths¹, S. Farkona¹, J. Van³, B. Urquhart⁵, I. Jurisica², L. Robinson⁶, M. Selzner¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute and Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Dept. of Laboratory Medicine and Pathobiology Institute, UHN, Toronto, ON, Canada, ⁵Schulich School of Medicine & Dentistry, UWO, London, ON, Canada, ⁶The Hospital for Sick Children Research Institute, Toronto, ON, Canada
*Purpose: Kidneys donated after circulatory death (DCD) contribute significantly to the donor pool, but have inferior outcomes. Normothermic ex-vivo kidney perfusion (NEVKP) results in significantly…
2020 American Transplant Congress
XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury
H. Ni¹, Y. Liu¹, W. Deng¹, J. Zhang², J. Xu¹, W. Zeng¹, N. Gong², Y. Miao¹
¹Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…
2020 American Transplant Congress
Is Ischemia Reperfusion Injury Immediately after Heart Transplantation Correlated to Increased Intimal Thickening in the First Year?
J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, A. Shen, K. Nishihara, A. Velleca, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Ischemia reperfusion injury (IRI) is not uncommon in heart transplant patients due to high dose inotropes, ischemic time, and technical surgical reasons. Ischemia in…
2020 American Transplant Congress
Accomplishment of Ischemia-Free Kidney Transplantation Using Normothermic Machine Perfusion
G. Chen, X. He, C. Wang, X. Yuan, M. Han, Z. Guo
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
*Purpose: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid…
2020 American Transplant Congress
Hypothermic Machine Perfusion Can Improve Hypoxia Tolerance in Human Discarded Liver
T. Ito, K. Kadono, H. Kojima, S. Kageyama, H. HIrao, K. Nakamura, K. J. Dery, A. E. Murray, J. Aziz, R. W. Busuttil, J. Kupiec-Weglinski, F. M. Kaldas
The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The wider use of livers from expanded criteria donors may help improve access to liver transplantation (LT). Normothermic machine perfusion in LT has been…
2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
P. Urbanellis¹, C. McEvoy¹, L. Mazilescu¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson², M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…
2020 American Transplant Congress
Nanodiamond-Doxorubicin Complexes Improve Hepatic Ischemia/Reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…
2020 American Transplant Congress
The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation
E. Van Loon, M. Coemans, A. Senev, D. Kuypers, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…
2020 American Transplant Congress
Short Recipient Warm Ischemia Time Improves Graft Survival in Liver Transplantation from Donation after Brain Death: 20-Year Experience of Liver Transplantation
A. Al-Kurd, T. Kitajima, K. Delvecchio, A. M. Elsabbagh, S. Yeddula, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, S. Nagai
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Although the correlation between warm ischemia time (WIT) and the outcomes of liver transplantation has been extensively studied, few investigations have focused on the…
2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…