Articles tagged "Ischemia"

2020 American Transplant Congress
Short Recipient Warm Ischemia Time Improves Graft Survival in Liver Transplantation from Donation after Brain Death: 20-Year Experience of Liver Transplantation
A. Al-Kurd, T. Kitajima, K. Delvecchio, A. M. Elsabbagh, S. Yeddula, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, S. Nagai
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Although the correlation between warm ischemia time (WIT) and the outcomes of liver transplantation has been extensively studied, few investigations have focused on the…
2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…
2020 American Transplant Congress
Risk Factors for Adverse Clinical Outcomes amongst Renal Transplant Candidates Undergoing Screening Angiography for Coronary Artery Disease
M. Shah¹, A. Yung¹, J. Ebinger¹, J. Mirocha², E. Huang³, D. Geft¹, A. Peng³, B. Azarbal¹
¹Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Department of Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Patient’s with ESRD undergoing evaluation for kidney transplantation routinely undergo screening for coronary artery disease (CAD). Screening recommendations in this population differ between ACC/AHA…
2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
S. Toldo, E. Mezzaroma, M. Quader
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…
2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
J. A. Reyes¹, C. Blanton¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. van Amersfoort², J. Torrealba³, Y. Yankol¹, A. D'Allessandro¹, L. Fernandez¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UT Soutwestern, Dallas, TX
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…
2020 American Transplant Congress
The Significance of Donor Gender on Graft Survival and Histological Ischemia Reperfusion Injury in Liver Transplant Patients
T. Ito, S. Kageyama, K. J. Dery, K. Nakamura, S. M. Younan, M. M. Lu, J. DiNorcia III, V. G. Agoian, H. Yersis, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Experimental animal models have demonstrated improved ability of females (F) to recover from ischemia-reperfusion injury (IRI) compared with males (M). Recent work combining human…
2020 American Transplant Congress
Treprostinil is Safe and Potentially Useful in Preventing Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients
R. Venkataramanan¹, I. H. Shaik², V. C. Pillai³, O. A. Almazroo⁴, M. K. Miah⁵, R. Xu², S. Dharmayan², A. Al-Khafaji², S. Ganesh², M. Molinari², A. Tevar², C. Hughes², A. Humar²
¹School Of Pharmacy, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³US Food and Drug Administration,, Silver Spring, MD, ⁴Saudi FDA, Riyadh, Saudi Arabia, ⁵Astra Zeneca, Boston, MA
*Purpose: Ischemia and reperfusion injury (IRI) is one of the unavoidable complications in orthotopic liver transplantion. Hepatic ischemic injury begins during the preservation of the…
2020 American Transplant Congress
Therapeutic Inhibition of Spleen Tyrosine Kinase Decreases Hepatic Damage after Ischemia Reperfusion Injury
A. Zarrinpar, V. Boominathan, A. Kobayashi, S. Duarte
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major challenge in transplantation. The complex array of interrelated signaling events in IRI have been studied individually, but…
2020 American Transplant Congress
New IGL-2 Perfusate in Liver HOPE Strategies
A. Panisello-Rosello¹, C. Castro-Benítez², E. Folch-Puy¹, J. Rosello-Catafau¹, R. Adam²
¹Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, ²Centre Hépato-Billiare, Hôpital Paul Brousse, Paris, France
*Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…