Articles tagged "Ischemia"

2022 American Transplant Congress
Gene Expression Changes Including Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², H. Ingram¹, A. Bajwa¹, D. Maluf³, V. Mas⁴, J. Eason⁵, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Maryland, Baltimore, MD, ⁵University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Ischemia reperfusion injury (IRI) is still one of the major problems in liver transplantation affecting long term outcomes. This study is sought out to…
2022 American Transplant Congress
The Post-operative Clinical Outcomes Of 59 Tanrp Cases In An International Cohort
J. Louca¹, N. Patel¹, S. Messer², J. Chindu², S. Large²
¹Cambridge University, Cambridge, United Kingdom, ²Royal Papworth Hospital, Cambridge, United Kingdom
*Purpose: Heart transplantation is an immensely effective service and is currently the only definitive treatment for heart failure. However, transplantation is limited by donor availability.…
2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, J. Hodrea¹, L. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
2022 American Transplant Congress
Inhibition of ITGB5 Protects Hepatocytes from Ischemia Reperfusion Injury
M. Dogan¹, S. Naik¹, C. Watkins¹, A. Bajwa¹, V. Mas², J. Eason³, C. Kuscu¹, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Surgery, University of Maryland, Baltimore, MD, ³University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Liver transplantation is the best treatment option for patients with end-stage liver disease (ESLD). Despite the increasing interest to the machine reperfusion, cold preservation…
2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation
G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera
Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ
*Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
2022 American Transplant Congress
Nebulized Mitochondria Localize to Transplanted Allografts and Improve Outcomes Following Lung Transplantation
D. Nord¹, Z. Tu², L. Langerude¹, A. McQuiston¹, J. Kwon³, S. Nadig⁴, T. Machuca⁵, C. Atkinson¹
¹Pulmonary Medicine, University of Florida, Gainesville, FL, ²University of Florida, Gaineville, FL, ³MUSC College of Medicine, Charleston, SC, ⁴Northwestern University, Charleston, SC, ⁵Department of Surgery, University of Florida, Gainesville, FL
*Purpose: Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has shown efficacy in the treatment of cardiac ischemic…
2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
E. H. Koritzinsky, D. Ueda, H. Tsuda, S. Miyari, R. L. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…
2022 American Transplant Congress
Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model
N. Abraham¹, M. Zhang¹, P. Cray², R. Neill¹, G. Cywinska¹, J. Migaly¹, R. Kahan¹, A. Pontula¹, J. Penaflor¹, Q. Gao¹, K. P. Samy¹, J. J. Pollara², V. Novokhatny³, M. G. Hartwig¹, A. S. Barbas¹
¹Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, ²Duke Division of Surgical Sciences, Pollara lab, Durham, NC, ³Bioscience Industrial Group, Grifols R&D, Durham, NC
*Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
2022 American Transplant Congress
Investigating RNA Interference-Mediated Inhibition of Liver Ischemia Reperfusion Injury During Liver Preservation
J. E. Buchwald¹, D. Echeverria², J. Sousa², N. McHugh², A. Khvorova², P. N. Martins³
¹RNA Therapeutics Institute, Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA, ²RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, ³Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA
*Purpose: Liver transplantation cures acute end-stage and chronic liver diseases, yet current strategies of organ preservation including static cold storage (SCS) and machine perfusion (MP)…

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