ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2022 American Transplant Congress

    HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels

    C. OBrien1, P. Hernandez1, S. Concors2, Z. Wang1, G. Ge3, A. Kozikowski4, W. Hancock5, M. Levine2

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Surgery, University of Pensylvania, Philadelphia, PA, 4College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 5Childrens Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
  • 2022 American Transplant Congress

    Role of Mitochondrial Transplantation in Enhancing Liver Regeneration Following Partial Hepatectomy

    G. Lamanilao1, C. Watkins1, C. Kuscu1, C. Kuscu1, J. Eason2, A. Bajwa1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2University of Tennessee/Methodist Transplant Institute, Memphis, TN

    *Purpose: Therapeutic strategies that accelerate the rate of liver regeneration following partial hepatectomy (PH) should be developed to reduce occurrences of small for size syndrome…
  • 2022 American Transplant Congress

    Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study

    L. Lo Faro1, A. Thorne2, H. Huang3, P. Charles3, M. Kaisar1, S. Davis3, F. Dengu1, S. Shaheed1, J. Mulvey1, R. Fischer3, D. Nasralla4, B. Kessler3, H. Leuvenink2, P. Friend1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University Medical Center Groningen, Groningen, Netherlands, 3Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Royal Free London NHS Foundation Trust, London, United Kingdom

    *Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
  • 2022 American Transplant Congress

    Impact of Cold Ischemia Times on 1 Year Kidney Transplant Outcomes

    T. Fletchinger, L. Burdine

    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: Recent organ allocation changes have increased travel and subsequent cold ischemia times (CIT) of kidney allografts. We sought to investigate the impact of prolonged…
  • 2022 American Transplant Congress

    An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model

    S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar

    University of Florida, Gainesville, FL

    *Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
  • 2022 American Transplant Congress

    Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Porcine Pancreas Grafts

    C. Parmentier, S. Ray, L. Mazilescu, M. Kawamura, T. Goto, Y. Noguchi, B. Arulratnam, S. Ganesh, M. Selzner, T. Reichman

    Multi-Organ Transplant Department, University Health Network - Toronto General Hospital, Toronto, ON, Canada

    *Purpose: The purpose of this study was to develop a stable porcine model for normothermic ex-vivo pancreas perfusion (NEVPP) for the preservation of grafts with…
  • 2022 American Transplant Congress

    Final Flow and Resistance with Cold Pulsatile Perfusion Preservation Are Independent Risk Factors for Dialysis in the First Week Post-Transplant, Analysis of SRTR Data

    D. S. Keith, E. Lessmann

    Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL

    *Purpose: To determine if final flow or resistance on cold pulsatile perfusion preservation (CPPP) have independent predictive value for dialysis in the first week post-transplant.*Methods:…
  • 2022 American Transplant Congress

    Superoxide in Cardiac Allografts from Donors After Circulatory Death

    M. Urban1, T. Bruett2, K. F. Duncan1, N. W. Markin3, M. M. Chacon3, M. C. Zimmerman4

    1Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, 2College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, 3Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 4Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE

    *Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
  • 2022 American Transplant Congress

    Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules

    T. Tsao1, E. Aminian1, A. Shemesh1, L. Tran1, P. Wang1, F. Deiter1, J. R. Greenland2, D. R. Calabrese1

    1University of California, San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, CA

    *Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
  • 2022 American Transplant Congress

    Exploration of the Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved from Circulatory Death

    S. Sakamoto1, M. Fukai1, K. Shibata1, H. Bochimoto2, N. Mohd Zin2, N. Kawamura1, T. Ishikawa1, M. Fujiyoshi1, T. Shimamura3, A. Taketomi1

    1Department of Gastroenterological Surgery 1, Hokkaido University Graduate School, Sapporo, Japan, 2Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan, 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan

    *Purpose: Although some investigators have reported favorable results of hypothermic machine perfusion (HMP) in liver transplantation, the efficacy to the hepatic graft retrieved from circulatory…
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