ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Intestinal transplantation"

  • 2016 American Transplant Congress

    Conditional Long Term Intestine Patient and Graft Survival Is Improving Under rATG Immunosuppression in Pediatric Intestine Transplantation.

    N. Celik,1 F. Vyas,1 G. Bond,1 K. Soltys,1 J. Rudolph,2 R. Sindhi,1 G. Mazariegos.1

    1Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; 2Intestinal Care and Rehabilitation Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Aim: We reviewed conditional graft survival and short and long term improvements in children receiving rATG (rabbit anti-thymocyte globulin) immunosuppression for intestine transplantation at a…
  • 2016 American Transplant Congress

    Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Patients.

    S. Okano,1 K. Hashimoto,1 K. Abu-Elmagd,1 J. Fung,1 D. Kish,2 K. Keslar,2 B. Min,2 R. Fairchild,2 C. Miller.1

    1Transplant Center, Cleveland Clinic, Cleveland, OH; 2Department of Immunology, Lerner Reserch Center, Cleveland Clinic, Cleveland, OH.

    [Background] IT is an efficacious treatment for chronic intestinal failure. Recent advance of immunosuppressive regimens have decreased the rejection rate and improved patient survival. The…
  • 2016 American Transplant Congress

    Innate Lymphoid Cells Play a Key Role in Controlling Antimicrobial Defense in Intestinal Transplant Recipients.

    J. Kaiser, C. Cosentino, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    MedStar Georgetown Transplant Institute, Washington DC.

    A. Infectious complications are the leading cause of death early after intestinal transplantation (ITx). Etiologies underlying this remain unclear. Innate lymphoid cells (ILCs) have very…
  • 2016 American Transplant Congress

    Number of Bacterial Isolates and Resistance Increases Mortality Risk in Intestinal Transplant Patients.

    D. Patel, H. Shah, T. Schiano, J. Moon, K. Iyer, S. Huprikar.

    Icahn School of Medicine at Mount Sinai, New York.

    BackgroundInfection is the most common complication in intestinal transplant (IT) recipients. Data regarding the impact of infections on outcomes following IT is limited.MethodsThis is a…
  • 2016 American Transplant Congress

    Generation of Naïve Donor-Derived Lymphocytes from Graft-Resident Lymphoid Progenitors After Human Intestinal Transplantation.

    J. Fu, J. Zuber, B. Shonts, S. Lau, A. Obradovic, T. Savage, M. Simpson, S. Yang, Y. Shen, M. Martinez, A. Griesemer, T. Kato, M. Sykes.

    Columbia University, New York.

    Multivisceral transplantation (MVTx) is associated with a lower rate of severe graft rejection than isolated intestinal transplantation (iITx). We recently demonstrated that mixed T cell…
  • 2016 American Transplant Congress

    CD45RO+/CD62L- Effector Memory T Cells Mediate Depletion Resistant Allograft Rejection in Intestinal Transplant Recipients.

    C. Cosentino, J. Kaiser, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    MedStar Georgetown Transplant Institute, Washington DC.

    A. A high risk of acute cellular rejection (ACR) is one of the key factors limiting intestinal transplantation (ITx). An extremely poor prognosis is related…
  • 2016 American Transplant Congress

    Colonization and Risk of Bacteremia by Multi-Drug Resistant Organisms in Intestinal Transplant Recipients.

    J. Simkins,1 J. Camargo,1 M. Morris,1 R. Vianna,2 T. Beduschi,2 L. Abbo.1

    1Medicine/Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL; 2Surgery, Miami Transplant Institute/University of Miami, Miami, FL.

    Background: This study is the first to evaluate colonization rates and subsequent bacteremia with multi-drug resistant organisms (MDRO) in intestinal transplant (ITx) recipients.Methods: Retrospective study…
  • 2016 American Transplant Congress

    Living Related Small Bowel Transplantation in Children, a Single-Center Experience – Growth, Development and Quality of Life 10 Years After Transplant.

    S. Garcia Aroz,1 I. Tzvetanov,1 E. Hetterman,2 J. Hoonbae,1 M. Spaggiari,1 J. Oberholzer,1 G. Testa,3 E. John,4 E. Benedetti.1

    1Surgery, University of Illinois, Chicago, IL; 2Pharmacy, University of Illinois, Chivago, IL; 3Surgery, Baylor Medical Center, Dallas, TX; 4Pediatrics, University of Illinois, Chicago, IL.

    Summary Background: Pediatric patients with irreversible intestinal failure present multiple challenges due to their young ages and their associated growth needs. We have previously published…
  • 2016 American Transplant Congress

    Clinical Rejection-Risk Assessment with Allospecific CD154+T-Cytotoxic Memory Cells (CD154+TcM) After Pediatric Liver or Intestine Transplantation (LTx, ITx).

    K. Soltys, G. Bond, G. Mazariegos, L. O'Toole, C. Trautz, L. Remaley, A. Zeevi, C. Ashokkumar, R. Sindhi.

    Surgery, Children's Hosp of Pgh of UPMC & Univ of Pittsburgh, Pittsburgh, PA.

    Background: In preclinical evaluation, CD154+TcM predict acute cellular rejection after LTx or ITx with sensitivity/specificity of 80%. Purpose/Methods: To summarize test indications and performance during…
  • 2016 American Transplant Congress

    Living Related Small Bowel Transplantation in Children – Patient and Graft Survival at 10 Years.

    S. Garcia Aroz,1 I. Tzvetanov,1 E. Hetterman,2 J. Hoonbae,1 M. Spaggiari,1 J. Oberholzer,1 G. Testa,3 E. John,1 E. Benedetti.1

    1Surgery, University of Illinois, Chicago; 2Pharmacy, University of Illinois, Chicago; 3Surgery, Baylor Medical Center, Dallas, TX.

    Objective: To describe a single-center experience of pediatric living related small bowel transplantation (LRSBtx) and to provide an overview of the outcomes of the children…
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