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Articles tagged "Intestinal transplantation"

  • 2017 American Transplant Congress

    Renal Outcomes Following Intestinal Transplantation.

    C. Puttarajappa,1 A. Humar,1 S. Hariharan,1 R. Cruz Jr,1 A. Ganoza,1 D. Landsittel,1,3 X. Gao,3 M. Bhattarai,1 H. Sogawa.1,2

    1Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Abdominal Transplant & Hepatobiliary Surgery, New York Medical College/ Westchester Medical Center, Valhalla, NY; 3Section on Biomarkers and Prediction Modeling, University of Pittsburgh, Pittsburgh, PA

    Purpose: Single center study of Intestinal Transplant recipients to evaluate epidemiology of dialysis and renal transplantation(RT) following Intestinal transplantation(IT).Methods: 288 adult patients who underwent first…
  • 2017 American Transplant Congress

    Ex Vivo Normothermic Perfusion of Isolated Segmental Porcine Bowel: A Novel Functional Model of the Small Intestine.

    M. Hamed,1 A. Barlow,1 S. Khosla,1 A. Sagar,1 F. Gribble,2 M. Murphy,3 G. Pettigrew,1 E. Bolton,1 J. Bradley,1 M. Nicholson,1 S. Hosgood,1 K. Saeb-Parsy.1

    1University Department of Surgery, Cambridge NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge, Cambridgeshire, United Kingdom; 2Wellcome Trust – MRC Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3MRC Mitochondrial Biology Unit, Cambridge, Cambridgeshire, United Kingdom

    Introduction: There is a need for the development of suitable large animal models for research in gastroenterology and intestinal transplantation. Ex vivo normothermic perfusion (EVNP)…
  • 2016 American Transplant Congress

    The Surgical Preconditioning in Patients with Ultra-Short Gut Using a Native Colonic Conduit for Anticipated Visceral Transplantation.

    M. Fujiki, K. Hashimoto, A. Khanna, K. Abu-Elmagd.

    Center of Gut Rehabilitation and Transplant, Cleveland Clinic, Cleveland, OH.

    Objective: The last decade witnessed the significant improvement in the morbidity and mortality of short gut syndrome (SGS) patients. However, still a challenge is the…
  • 2016 American Transplant Congress

    Donor Risk Index for Intestinal & Multi-Visceral Transplantation.

    G. Zeng,1 M. Chen,2 X. Zhao,3 D. Landsittel,2 H. Sogawa.4

    1Department of Pathology, The Thomas E Starzl Transplantation Institute, Pittsburgh, PA; 2Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA; 3Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; 4Multi-Organ Transplant & Hepatobiliary, Westchester Medical Center, Valhalla, NY.

    Background: The Donor Risk Index and the Kidney Donor Profile Index (KDPI) have been utilized for liver and kidney transplantation in clinical and research setting.…
  • 2016 American Transplant Congress

    Appraisal of Alternative Immunosuppression Regimens in Intestinal Transplant Recipients: A Single Center Experience.

    R. Patel, M. Keck, D. Collier, M. Vacha.

    Nebraska Medicine, Omaha, NE.

    Purpose: The purpose of this study was to compare outcomes (acute cellular rejection, graft loss, mortality) in intestinal transplant recipients who were converted from the…
  • 2016 American Transplant Congress

    Use of En-Bloc Vascularized Rectus Sheath Allograft to Achieve Abdominal Closure in Pediatric Liver and Multivisceral Transplantation.

    J. Reddy, A. Rege, D. Vikraman, B. Collins, T. Brennan, S. Knechtle, D. Sudan, K. Ravindra.

    Surgery, Duke University, Durham, NC.

    Background: Abdominal wall closure is often challenging in pediatric liver (LT) and multivisceral transplantation (MVT) due to size discrepancy of donor & recipient and abdominal…
  • 2016 American Transplant Congress

    Intestinal Retransplantation in Children: Single Center Experience.

    N. Celik,1 F. Vyas,1 G. Bond,1 K. Soltys,1 J. Rudolph,2 R. Sindhi,1 G. Mazariegos.1

    1Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; 2Intestinal Care and Rehabilitation Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Aim: To analyze the patient and graft characteristics and improvement in patient outcomes for intestinal retransplantation (Re-ITx) in the era of induction immunosuppression with the…
  • 2016 American Transplant Congress

    Normothermic Ex-Vivo Perfusion of the Intestine: The Introduction of an Innovative Physiologic Model with Novel Biomarkers.

    B. Soliman, T. Okamoto, C. Quintini, Q. Liu, M. Fujiki, A. Khanna, K. Hashimoto, J. Fung, K. Abu-Elmagd.

    General Surgery, Transplant Center, Cleveland Clinic Foundation, Cleveland, OH.

    Purpose: Ischemia reperfusion injury is a major risk factor for short and long-term functional survival after intestinal transplantation. Normothermic machine perfusion is an emerging biotechnology…
  • 2016 American Transplant Congress

    IL-17-Producing CCR6+CD4+ Th17 Cells Drive Intestinal Allograft Rejection in Humans.

    J. Kaiser, C. Cosentino, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    MedStar Georgetown Transplant Institute, Washington DC.

    A. Allograft rejection remains a significant source of mortality and morbidity in intestinal transplant (ITx) recipients. However, the underlying mechanisms remain unclear. The purpose of…
  • 2016 American Transplant Congress

    Kidney Survival Outcomes in Combined Intestinal-Kidney Transplant: An Analysis of the UNOS/OPTN Database 2000-2014.

    A. Sharfuddin, T. Taber, M. Yaqub, I. Moinuddin, A. Khalil, O. Adebiyi, M. Mujtaba.

    Medicine/Nephrology, Indiana University, Indianapolis.

    Background: Intestinal transplants (isolated/modified/multi-visceral) carry a high morbidity and mortality. Kidney outcomes after combined intestinal (IT) with kidney transplant (CIKT) remain largely uninvestigated.Methods: The UNOS…
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