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Articles tagged "Intestinal transplantation"

  • 2018 American Transplant Congress

    Temporal and Geographical Trends of Intestinal Transplantation in the USA

    M. Segovia,1 S. Jafri,3 B. Summers,3 T. Schiano,2 T. Pietrowsky,3 A. Al-Osaimi,5 A. Mavis,1 S. Horslen.4

    1Duke Univ, Durham; 2Mt Sinai Hosp, NY; 3Henry Ford Hosp, Detroit; 4Seattle Children's Hosp, Seattle; 5Temple Univ, Philadelphia.

    Intestinal transplantation (IT) is uncommon compared to other organ transplants. We examined the temporal and geographical trends of centers that perform IT in the USAWe…
  • 2018 American Transplant Congress

    CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD

    O. Aguirre, B. Houlihan, A. Karabala, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
  • 2018 American Transplant Congress

    Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts

    S. Okano,1,2 K. Abu-Elmagd,2 D. Kish,1 K. Keslar,1 M. Fujiki,2 G. Costa,2 C. Miller,2 W. Baldwin,1 R. Fairchild,1 K. Hashimoto.2

    1Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 2General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

    In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…
  • 2018 American Transplant Congress

    Cytomegalovirus (CMV) Infection in Small Intestinal and Multivisceral Transplant Recipients: The Role of Donor Selection on CMV Incidence and Outcomes

    H. Grewal, M. Czech, C. Matsumoto, M. Natarajan, J. Fraker, W. Fan, J. Timpone.

    Medstar Georgetown University Hospital, Washington DC.

    Introduction: CMV infection remains an important cause of morbidity, allograft enteritis, and allograft loss in small intestinal (SIT) and multivisceral transplant (MVT) recipients. As the…
  • 2018 American Transplant Congress

    Tacrolimus and Isavuconazole Therapy: What about the Drug Interaction?

    C. Gill,1 N. Mercuro,1 R. Kenney,1 A. Jantz,1 B. Summers,1 N. Sulejmani,1 S. Davis.1,2

    1Henry Ford Hospital, Detroit; 2Wayne State University, Detroit, MI.

    Introduction:Isavuconazole (ISV) is a triazole antifungal that is often utilized in solid organ transplant recipients (SOTR) for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole…
  • 2018 American Transplant Congress

    Immunomonitoring of Operational Tolerance in Intestinal Transplantation

    O. Aguirre, B. Houlihan, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
  • 2018 American Transplant Congress

    Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review

    M. Henry, M. Vacha, M. Keck, D. Florescu.

    Nebraska Medicine, Omaha, NE.

    Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…
  • 2018 American Transplant Congress

    Bloodstream Infection Caused by Enteric Organisms during the First 6 Months after Intestinal Transplant

    J. Simkins,1 J. Morillas-Rodriguez,1 M. Morris,1 L. Abbo,1 J. Camargo,1 R. Vianna.2

    1Medicine/Infectious Diseases, University of Miami, Miami; 2Surgery, University of Miami, Miami.

    Background: Irreversible intestinal failure can be treated effectively with intestinal transplant (ITx). Infections are common after ITx but data on bloodstream infection (BSI) due to…
  • 2017 American Transplant Congress

    Clostridium difficile Infection in Intestinal Transplant Recipients.

    V. Goldenberg,1 A. Berbel,2 J. Camargo,1 J. Simkins.1

    1Medicine, Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL; 2Medicine, University of Miami Miller School of Medicine, Miami, FL

    Background: Clostridium difficile infection (CDI) data in intestinal transplant (ITx) recipients is lacking. This study was performed to evaluate prevalence, risk factors, treatments and outcomes…
  • 2017 American Transplant Congress

    Operational Tolerance in Intestinal Transplantation: A Proven Possibility.

    B. Houlihan,1 P. Cha,1,2 C. Cosentino,1,2 J. Kaiser,1,2 A. Shukla,1 J. Hawksworth,1,2 C. Matsumoto,1 T. Fishbein,1 A. Kroemer.1

    1Transplant Department, Medstar Georgetown University Hospital, Washington, DC; 2Surgery, Walter Reed National Military Medical Center, Bethesda, MD

    A The purpose of this study is to immunologically characterize the first operationally tolerant intestinal transplant (ITx) patient known to date.B Flow cytometry and rtPCR…
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