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American Transplant Congress abstracts

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Articles tagged "Intestinal transplantation"

  • 2018 American Transplant Congress

    Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts

    S. Okano,1,2 K. Abu-Elmagd,2 D. Kish,1 K. Keslar,1 M. Fujiki,2 G. Costa,2 C. Miller,2 W. Baldwin,1 R. Fairchild,1 K. Hashimoto.2

    1Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 2General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

    In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…
  • 2018 American Transplant Congress

    Cytomegalovirus (CMV) Infection in Small Intestinal and Multivisceral Transplant Recipients: The Role of Donor Selection on CMV Incidence and Outcomes

    H. Grewal, M. Czech, C. Matsumoto, M. Natarajan, J. Fraker, W. Fan, J. Timpone.

    Medstar Georgetown University Hospital, Washington DC.

    Introduction: CMV infection remains an important cause of morbidity, allograft enteritis, and allograft loss in small intestinal (SIT) and multivisceral transplant (MVT) recipients. As the…
  • 2018 American Transplant Congress

    Tacrolimus and Isavuconazole Therapy: What about the Drug Interaction?

    C. Gill,1 N. Mercuro,1 R. Kenney,1 A. Jantz,1 B. Summers,1 N. Sulejmani,1 S. Davis.1,2

    1Henry Ford Hospital, Detroit; 2Wayne State University, Detroit, MI.

    Introduction:Isavuconazole (ISV) is a triazole antifungal that is often utilized in solid organ transplant recipients (SOTR) for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole…
  • 2018 American Transplant Congress

    Immunomonitoring of Operational Tolerance in Intestinal Transplantation

    O. Aguirre, B. Houlihan, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
  • 2018 American Transplant Congress

    Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review

    M. Henry, M. Vacha, M. Keck, D. Florescu.

    Nebraska Medicine, Omaha, NE.

    Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…
  • 2018 American Transplant Congress

    Bloodstream Infection Caused by Enteric Organisms during the First 6 Months after Intestinal Transplant

    J. Simkins,1 J. Morillas-Rodriguez,1 M. Morris,1 L. Abbo,1 J. Camargo,1 R. Vianna.2

    1Medicine/Infectious Diseases, University of Miami, Miami; 2Surgery, University of Miami, Miami.

    Background: Irreversible intestinal failure can be treated effectively with intestinal transplant (ITx). Infections are common after ITx but data on bloodstream infection (BSI) due to…
  • 2018 American Transplant Congress

    Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients

    O. Aguirre, B. Houlihan, A. Karabala, C. Cosentino, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…
  • 2018 American Transplant Congress

    Increased Pre-Transplant Rejection-Risk Measured with Allospecific T-Cells Predicts Delayed Immunosuppression Minimization in Children with Intestine Transplantation.

    K. Soltys, C. Ashokkumar, G. Mazariegos, G. Bond, M. Ningappa, A. Khanna, A. Ganoza, Q. Sun, R. Sindhi.

    Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) are used clinically to predict acute cellular rejection (ACR) after intestine transplantation (ITx) in children <21 years old within…
  • 2017 American Transplant Congress

    Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.

    P. Cha, B. Houlihan, J. Kaiser, C. Cosentino, B. Monahan, A. Shukla, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer.

    Transplant, MedStar Georgetown Transplant Institute, Washington, DC

    A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…
  • 2017 American Transplant Congress

    Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Recipients (rc) and Suppress Recipient T-Cell (T) Response Against Donor Antigen.

    S. Okano,1 D. Kish,2 K. Keslar,2 W. Baldwin,2 R. Fairchild,1 C. Miller,1 K. Abu-Elmagd,1 A. Khanna,1 M. Fujiki,1 J. Fung,1 G. Costa,1 K. Hashimoto.1

    1Transplant Center, Dept. General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH; 2Dept. Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    [Introduction] Recent advances of immunosuppressive regimens have decreased rejection rate and improved rc survival of IT. MDSC are potent immature myeloid cells capable of suppressing…
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