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American Transplant Congress abstracts

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Articles tagged "Intestinal transplantation"

  • 2018 American Transplant Congress

    Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review

    M. Henry, M. Vacha, M. Keck, D. Florescu.

    Nebraska Medicine, Omaha, NE.

    Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…
  • 2018 American Transplant Congress

    Bloodstream Infection Caused by Enteric Organisms during the First 6 Months after Intestinal Transplant

    J. Simkins,1 J. Morillas-Rodriguez,1 M. Morris,1 L. Abbo,1 J. Camargo,1 R. Vianna.2

    1Medicine/Infectious Diseases, University of Miami, Miami; 2Surgery, University of Miami, Miami.

    Background: Irreversible intestinal failure can be treated effectively with intestinal transplant (ITx). Infections are common after ITx but data on bloodstream infection (BSI) due to…
  • 2018 American Transplant Congress

    Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients

    O. Aguirre, B. Houlihan, A. Karabala, C. Cosentino, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…
  • 2018 American Transplant Congress

    Increased Pre-Transplant Rejection-Risk Measured with Allospecific T-Cells Predicts Delayed Immunosuppression Minimization in Children with Intestine Transplantation.

    K. Soltys, C. Ashokkumar, G. Mazariegos, G. Bond, M. Ningappa, A. Khanna, A. Ganoza, Q. Sun, R. Sindhi.

    Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) are used clinically to predict acute cellular rejection (ACR) after intestine transplantation (ITx) in children <21 years old within…
  • 2018 American Transplant Congress

    The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study

    P. Liou,1 M. Martinez,1 J. Fu,2 M. Velasco,1 A. Griesemer,1 S. Lobritto,1 J. Vittorio,1 S. Ravella,1 B. Levin,3 J. Emond,1 M. Sykes,2 T. Kato.1

    1Center for Liver Disease and Transplantation, Columbia University, New York, NY; 2Columbia Center for Translational Immunology, Columbia University, New York, NY; 3Department of Biostatistics, Columbia University, New York, NY.

    Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…
  • 2018 American Transplant Congress

    Temporal and Geographical Trends of Intestinal Transplantation in the USA

    M. Segovia,1 S. Jafri,3 B. Summers,3 T. Schiano,2 T. Pietrowsky,3 A. Al-Osaimi,5 A. Mavis,1 S. Horslen.4

    1Duke Univ, Durham; 2Mt Sinai Hosp, NY; 3Henry Ford Hosp, Detroit; 4Seattle Children's Hosp, Seattle; 5Temple Univ, Philadelphia.

    Intestinal transplantation (IT) is uncommon compared to other organ transplants. We examined the temporal and geographical trends of centers that perform IT in the USAWe…
  • 2018 American Transplant Congress

    CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD

    O. Aguirre, B. Houlihan, A. Karabala, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
  • 2018 American Transplant Congress

    Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts

    S. Okano,1,2 K. Abu-Elmagd,2 D. Kish,1 K. Keslar,1 M. Fujiki,2 G. Costa,2 C. Miller,2 W. Baldwin,1 R. Fairchild,1 K. Hashimoto.2

    1Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 2General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

    In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…
  • 2017 American Transplant Congress

    Graft-versus-Host Disease in Intestine Transplantation.

    J. Clouse, C. Kubal, B. Ekser, J. Fridell, R. Mangus.

    Surgery, Indiana University School of Medicine, Indianapolis, IN

    PurposeThis study reports the incidence, location, and outcomes of graft-versus-host disease (GVHD) at an active intestine transplant center. Subgroup analysis is employed to assess for…
  • 2017 American Transplant Congress

    Effect of Preformed Donor-Specific Antibodies in Intestine/Multivisceral Transplantation.

    M. Safwan,1 M. Rizzari,1 K. Collins,1 A. Yoshida,1 S. Skorupski,2 O. Fagoaga,2 M. Abouljoud,1 S. Nagai.1

    1Divison of Transplant and Hepatobiliary Surgery, Henry Ford Transplant Institute, Detroit, MI; 2Transplant Immunology, Henry Ford Hospital, Detroit, MI

    Aim: To analyze the effect of preformed donor-specific antibodies (DSA) in intestine/multivisceral transplantation patients.Methods: Retrospective review of preformed and de novo DSAs of all intestine/multivisceral…
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