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Articles tagged "Intestinal transplantation"

  • 2019 American Transplant Congress

    Post-transplant Lymphoproliferative Disorder Following Intestine Transplantation: Contemporary Single Center Experience

    A. Zimmerman, J. Hawksworth, A. Kroemer, P. Radkani, K. Khan, S. Kaufman, N. Yazigi, S. Subramanian, T. Fishbein, C. Matsumoto

    Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: The purpose of this study was to examine the characteristics and risk factors for PTLD after intestinal transplant.*Methods: Retrospective review of intestinal transplant recipients…
  • 2019 American Transplant Congress

    A Multicenter Study Of mTOR Inhibitor Use In Intestine And Multivisceral Transplantation

    M. C. Segovia1, A. Mavis1, J. Boike2, Y. Patel1, T. Schiano3, S. Jafri4

    1Duke, Durham, NC, 2NWU, Chicago, IL, 3Mt Sinai, NY, NY, 4Henry Ford, Detroit, MI

    *Purpose: Review the frequency, indications and outcomes of the use of mTOR inhibitors (mTOR) after intestine (IT) and multivisceral transplantation (MVT) at multiple centers in…
  • 2019 American Transplant Congress

    Viral Enteritis in Intestinal Transplant Recipients

    A. Servais, M. Vacha, D. F. Florescu, M. Keck

    Nebraska Medicine, Omaha, NE

    *Purpose: To evaluate viral enteritis episodes in intestinal transplant recipients (ITR)*Methods: This retrospective review included ITR transplanted between January 2008 and December 2016. Data for…
  • 2019 American Transplant Congress

    The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?

    L. Belyayev1, M. Sadat2, K. Loh3, S. Moturi2, K. Khan2, J. Hawksworth2, C. Matsumoto2, T. M. Fishbein2, A. Kroemer2

    1Surgery, Walter Reed National Military Medical Center, Bethesda, MD, 2Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, 3Pediatrics, Children’s National Medical Center, Washington D.C., DC

    *Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
  • 2019 American Transplant Congress

    Challenges to Inpatient Management Post Abdominal Wall Transplant (AWT) – From App’s Perspective

    K. Hattori, D. Sudan, K. Ravindra

    Duke University hospital, Durham, NC

    *Purpose: To highlight the unique features of caring for an AWT recipient and identify areas of improvement for future cases*Methods: AWT is an innovative adjunct…
  • 2019 American Transplant Congress

    An International Multicentre Validation Study of the Toronto Listing Criteria for Pediatric Intestinal Transplant

    A. J. Roberts1, P. W. Wales2, S. V. Beath3, H. M. Evans1, J. Hind4, T. Wong5, D. Mercer6, J. Yap7, C. Belza8, D. Grant9, Y. Avitzur10

    1Department of Paediatric Gastroenterology, Starship Child Health - Auckland District Health Board, Auckland, New Zealand, 2Division of General & Thoracic Surgery, Hospital for Sick Children, University of Toronto,, Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada, 3The Liver Unit, Birmingham Children’s Hospital, Birmingham, United Kingdom, 4Paediatric Liver, GI & Nutrition Centre, King's College Hospital, London, United Kingdom, 5The Liver Unit, Birmingham Children's Hospital, Birmingham, United Kingdom, 6Children’s Hospital and Medical Centre, Omaha, NE, 7Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, 8Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada, 9Department of Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 10Division of Gastroenterology, Hepatology & Nutrition, Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada

    *Purpose: Current intestinal transplantation (IT) listing criteria from 2001 have limited ability to predict the need for IT in the current era of intestinal failure…
  • 2019 American Transplant Congress

    Surgical Management Of Five Hundred Patients With Chronic Gut Failure At A Single Center: Autologous Reconstruction Versus Transplantation

    S. Armanyous, Y. Fouda, M. Fujiki, N. Parekh, M. Osman, R. Girlanda, K. Hashimoto, G. Costa, K. Abu-Elmagd

    Cleveland Clinic, Cleveland, OH

    *Purpose: To define the evolving role of autologous gut reconstruction (AGR) in the management of total parenteral nutrition (TPN)-dependent-chronic gut failure (CGF) patients with special…
  • 2018 American Transplant Congress

    Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients

    O. Aguirre, B. Houlihan, A. Karabala, C. Cosentino, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…
  • 2018 American Transplant Congress

    Increased Pre-Transplant Rejection-Risk Measured with Allospecific T-Cells Predicts Delayed Immunosuppression Minimization in Children with Intestine Transplantation.

    K. Soltys, C. Ashokkumar, G. Mazariegos, G. Bond, M. Ningappa, A. Khanna, A. Ganoza, Q. Sun, R. Sindhi.

    Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) are used clinically to predict acute cellular rejection (ACR) after intestine transplantation (ITx) in children <21 years old within…
  • 2018 American Transplant Congress

    The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study

    P. Liou,1 M. Martinez,1 J. Fu,2 M. Velasco,1 A. Griesemer,1 S. Lobritto,1 J. Vittorio,1 S. Ravella,1 B. Levin,3 J. Emond,1 M. Sykes,2 T. Kato.1

    1Center for Liver Disease and Transplantation, Columbia University, New York, NY; 2Columbia Center for Translational Immunology, Columbia University, New York, NY; 3Department of Biostatistics, Columbia University, New York, NY.

    Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…
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