2019 American Transplant Congress
First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant
1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA
*Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…2019 American Transplant Congress
Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation
*Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…2019 American Transplant Congress
Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…2019 American Transplant Congress
Deceased Donor Vascularized Abdominal Wall Allograft Procurement – Lessons Learned from Early Experiences
Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC
*Purpose: Vascularized abdominal wall allografts (AWA), which protect solid organs in patients with loss of abdominal domain or extensive abdominal wall damage, remain an essential…2019 American Transplant Congress
De Novo Glomerulonephritis after Non Renal Abdominal Organ Transplantation
*Purpose: Pediatric recipients of non renal abdominal organs may develop renal abnormalities of uncertain etiology. We describe for the first time de novo lupus-like glomerulonephritis…2019 American Transplant Congress
Predicting Risk of Cytomegalovirus with Viral-Antigen-Specific CD154+ T-cells after Liver or Intestine Transplantation
Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Cytomegalovirus (CMV)-specific T-cells express IFNγ, measure cell-mediated immunity to CMV and can guide the timing and duration of antiviral therapy. CMV-specific T-cells also co-express…2019 American Transplant Congress
Anti-Xa Level Monitoring for Treatment Dose Enoxaparin in Liver/Intestine Transplant Recipients
Jackson Memorial Hospital, Miami, FL
*Purpose: Evaluate the use of anti-Xa levels in therapeutic enoxaparin dosing in liver/intestine transplant recipients.*Methods: A single-center retrospective chart review was conducted on liver/intestine transplant…2018 American Transplant Congress
Cytomegalovirus (CMV) Infection in Small Intestinal and Multivisceral Transplant Recipients: The Role of Donor Selection on CMV Incidence and Outcomes
Medstar Georgetown University Hospital, Washington DC.
Introduction: CMV infection remains an important cause of morbidity, allograft enteritis, and allograft loss in small intestinal (SIT) and multivisceral transplant (MVT) recipients. As the…2018 American Transplant Congress
Tacrolimus and Isavuconazole Therapy: What about the Drug Interaction?
1Henry Ford Hospital, Detroit; 2Wayne State University, Detroit, MI.
Introduction:Isavuconazole (ISV) is a triazole antifungal that is often utilized in solid organ transplant recipients (SOTR) for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole…2018 American Transplant Congress
Immunomonitoring of Operational Tolerance in Intestinal Transplantation
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
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