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Articles tagged "Intestinal transplantation"

  • 2015 American Transplant Congress

    Impact of Alloreactivity On Intra-Graft T Cell Homeostasis Following Small Bowel Transplantation

    J. Zuber, B. Shonts, S. Lau, S. Coley, S. Yang, J. Weiner, S. DeWolf, D. Farber, Y. Shen, M. Martinez, T. Kato, M. Sykes.

    Columbia University Medical Center, New York.

    The impact of alloreactivity on the turnover rate, phenotype and repertoire of gut-resident lymphoid cells populating human intestinal allografts is unknown. We prospectively analyzed the…
  • 2015 American Transplant Congress

    Th17-Mediated Alloimmune Responses Play a Key Role in Intestinal Allograft Rejection in Humans

    A. Kroemer, S. Wanta, J. Diaz, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein.

    The Georgetown Transplant Institute, Washington, DC.

    The majority of transplanted intestines still falls victim to allograft enteropathy, the underlying mechanisms of which are poorly understood. The purpose of this study was…
  • 2015 American Transplant Congress

    Severe Sarcopenia and Increased Fat Stores in Pediatric Patients With Liver, Kidney and Intestine Failure

    W. Bush, C. Miller, C. Kubal, J. Fridell, A. Tector, R. Mangus.

    Transplant Division, Dept of Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: Recent research suggests that measures of frailty, such as nutrition status, may be important predictors of surgical and transplant outcomes. The objectively calculated degree…
  • 2015 American Transplant Congress

    Thymoglobulin Administration During Multi-Visceral and Isolated Small Bowel Procurement Does Not Adversely Affect the Survival of Harvested Organs

    G. Jain, T. Burnett, J. Preheim, L. Vargas, W. Grant, A. Langnas, D. Mercer, G. Jain.

    Division of Transplantation, Department of Surgery, University of Nebraska Medical Center, Omaha, NE.

    Anti-thymocyte globulin administration in donors before intestinal procurement may result in decreased graft versus-host disease (GVHD) due to reduced recipient lymphocyte trafficking after reperfusion. Reluctance…
  • 2015 American Transplant Congress

    Hybrid Ostomy – New Technique in Intestinal Transplantation

    T. Beduschi, J. Garcia, P. Ruiz, A. Tekin, G. Selvaggi, S. Nishida, J. Fan, R. Vianna.

    Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.

    Introduction: Many experimental non-invasive methods have been tested to assess the intestinal graft, but none of them proved to be reliable. Biopsy of the intestine…
  • 2015 American Transplant Congress

    Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation

    J. Weiner, J. Zuber, B. Shonts, S. Yang, M. Martinez, T. Kato, M. Sykes.

    Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.

    Introduction: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation…
  • 2015 American Transplant Congress

    Pre-Operative Assessment of Body Composition in Adult Multivisceral Transplant Candidates

    R. Cruz, H. Sogawa, G. Bond, K. Soltys, R. Sindhi, G. Mazariegos, A. Humar, A. DiMartini.

    Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    Body Mass Index is commonly used, but is likely to be an inexact measurement of nutritional status. For this reason, we examined whether body composition…
  • 2015 American Transplant Congress

    Allograft Enterectomy as a Life-Saving Procedure and Salvage for Retransplantation

    S. Nagai, R. Mangus, B. Ekser, C. Kubal, J. Fridell, A. Tector.

    Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: Allgraftectomy after solid organ transplantation is usually performed as a palliative therapy. After isolated intestinal transplantation (IIT), allograft enterectomy is sometimes necessary as a…
  • 2015 American Transplant Congress

    Tacrolimus Trough Concentrations Increase in Intestinal Transplant Recipients During Episodes of Acute Cellular Rejection

    A. Lichvar,1 D. Deen,2 H. Johnson,1 J. Bonner,3 G. Bond,4 G. Costa,4 R. Cruz,4 K. Abu-Elmagd,5 R. Venkataramanan.6,7

    1Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Department of Pharmacy, Memorial University Medical Center, Savannah, GA; 3Northern Institute for Cancer Research at Newcastle University, Tyne and Wear, United Kingdom; 4Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; 5Center for Gut Rehabilitation and Transplantation, Cleveland Clinic, Cleveland, OH; 6Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; 7Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Introduction: Acute cellular rejection (ACR) in small bowel transplant recipients is expected to increase intestinal permeability and to reduce intestinal CYP3A/p-glycoprotein activity. These changes may…
  • 2015 American Transplant Congress

    Immunodeficiency Assessment in Pediatric Intestinal Failure Patients

    J. Garcia,1 T. Beduschi,1 C. Biaggi,2 E. Perez,2 A. Tekin,1 M. McGetrick,3 L. Cubley,1 P. Ruiz,1 J. Fan,1 S. Nishida,1 G. Selvaggi,1 R. Vianna.1

    1Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; 2Pediatrics, University of Miami Miller School of Medicine, Miami, FL; 3University of Miami Miller School of Medicine, Miami, FL.

    Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
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