ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Interleukin-2 receptor"

  • 2020 American Transplant Congress

    Comparison of Basiliximab for Induction Therapy in Kidney Transplant Recipients on Post-Operative Days 0 and 4 versus Post-Operative Days 0 and 3

    C. Schardt, R. Yau, A. Burgos, C. Tunwar

    Pharmacy, CHI St. Luke's Health Baylor St. Luke's Medical Center, Houston, TX

    *Purpose: Current dosing recommendations for the administration of basiliximab on post-operative days (POD) 0 and 4 stem from two phase 3 renal transplant studies. Limited…
  • 2019 American Transplant Congress

    PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules

    M. Sadasivam, S. Noel, S. Lee, J. Gong, A. Hamad, H. Rabb

    Johns Hopkins University and School of Medicine, Baltimore, MD

    *Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
  • 2019 American Transplant Congress

    To Each Their Own: Center-Level Variation in Tailoring Induction Immunosuppression to Kidney Transplant Recipients

    S. Bae, A. Massie, J. Garonzik Wang, M. McAdams DeMarco, J. Coresh, D. Segev

    Johns Hopkins University, Baltimore, MD

    *Purpose: Ideally, induction immunosuppression should be selected in a personalized manner. However, there is little knowledge of what clinical factors are considered in this process…
  • 2019 American Transplant Congress

    Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking

    W. Piao1, L. Li2, V. Saxena2, Y. Xiong2, M. WillsonShirkey2, C. Paluskievicz2, J. Bromberg3

    1Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, 2Surgery, U. Maryland, Baltimore, Baltimore, MD, 3Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
  • 2019 American Transplant Congress

    Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity

    S. K. Eskandari1, M. B. Melo2, I. Sulkaj1, N. Li2, S. Cai1, H. Allos1, J. Y. Choi1, D. J. Irvine2, J. R. Azzi1

    1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 2David H. Koch Institute for Integrative Cancer Research, Cambridge, MA

    *Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
  • 2019 American Transplant Congress

    Peri-Operative Basiliximab is Not Associated with Post-Transplant Hepatocellular Carcinoma Recurrence in Liver Transplant Recipients

    D. Salerno1, N. Lange1, E. Simoneau2, C. Sammons3, D. Bley1, R. S. Brown Jr4, J. Emond2, K. Halazun5

    1Pharmacy, NewYork-Presbyterian Hospital, New York, NY, 2Surgery, Columbia University Irving Medical Center, New York, NY, 3Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA, 4Medicine, Weill Cornell Medicine, New York, NY, 5Surgery, Weill Cornell Medicine, New York, NY

    *Purpose: The optimal immunosuppression for liver transplant recipients (LTR) with hepatocellular carcinoma (HCC) is unknown. Basiliximab, an interleukin-2 receptor antagonist (IL-2RA), confers immunosuppression for LTR…
  • 2018 American Transplant Congress

    Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression

    S. Eskandari,1 M. Bandeira Melo,2 J. Assaker,1 A. Mansouri,1 S. Cai,1 B. Al Dulaijan,1 M. Mohamed,1 D. Irvine,2 J. Azzi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

    Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…
  • 2018 American Transplant Congress

    TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…
  • 2017 American Transplant Congress

    Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.

    H. Xu,1 S. Dahiya,2 L. Wang,2 T. Akimova,2 W. Hancock,2,4 S. Levin.3

    1Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; 3Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; 4Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia

    Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
  • 2017 American Transplant Congress

    Using Basiliximab Does Not Increase De Novo DSA Incidence but Reduces Cytomegalovirus Infections and Neoplastic Complications in Non-Sensitized Kidney Transplant Patients.

    M. Marron-Wojewodzki,1 I. Szwarc,1 C. Rene,2 J.-F. Eliaou,2 G. Mourad,1 M. Le Quintrec.1,3

    1Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; 2Departement of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; 3Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France

    Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (AMR) and graft failure. After dnDSA development, 24% of the…
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