ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Interferon (IFN)"

  • 2017 American Transplant Congress

    IL-33 Enhances the Ability of Dendritic Cells to Expand Human Regulatory T Cells.

    Y. Zhao,1 H. Zhang,1 L. Mathews,1 H. Turnquist,1,2 A. Thomson.1,2

    1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Introduction:The importance of increasing the number of regulatory T cells (Treg) relative to T effectors for the promotion of long-term experimental allograft survival/tolerance is well-established.…
  • 2017 American Transplant Congress

    Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.

    T. Maehana, T. Tanaka, N. Masumori.

    Urology, Sapporo Medical University School of Medicine, Sapporo, Japan

    Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
  • 2017 American Transplant Congress

    CD8+ TAb-supp Cells Are Key Inhibitors of Humoral Alloimmunity by Inhibiting CD4+TFH Cells and Killing Germinal Center B Cells.

    J. Zimmerer, C. Avila, S. Elzein, B. Ringwald, R. Warren, G. Bumgardner.

    Surgery, The Ohio State University Wexner Medical Center, Columbus, OH

    Alloantibodies (alloAb) play a critical role in acute and chronic rejection after transplantation (Tx). It is well known that CD4+ T cells and B cells…
  • 2017 American Transplant Congress

    High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells.

    A. Perez-Gutierrez, D. Metes, Y. Ono, A. Thomson, M. Ezzelarab.

    Surgery, University of Pittsburgh, Pittsburgh, PA

    BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…
  • 2017 American Transplant Congress

    Assessment of C4d Positive Biopsies with No Histological Evidence of Inflammation Using Nanostring nCounter Technology.

    K. Dominy,1 M. Willicombe,3 T. Al Johani,2 J. Galliford,3 A. McLean,3 T. Cook,3 C. Roufosse.3

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2King Saud University, Riyadh, Saudi Arabia; 3Imperial College Healthcare NHS Trust, London, United Kingdom

    Deposition of C4d has been an established part of the Banff classification scheme for antibody mediated rejection (AbMR) since 2001. More recently, C4d negative AbMR…
  • 2016 American Transplant Congress

    IFN-γ and Contact-Dependent Cytotoxicity Are Rate-Limiting for NK Cells in a Model of Antibody-Mediated Chronic Rejection.

    C. Lin,1 R. Plenter,1 R. Gill.2

    1Medicine, University of Colorado, Denver, Aurora, CO; 2Surgery, University of Colorado, Denver, Aurora, CO.

    BACKGROUND. Natural killer (NK) cells are key components of the innate immune that contribute to acute and chronic graft rejection. After engagement with antibody, NK…
  • 2016 American Transplant Congress

    Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.

    L. Higdon,1 K. Margulies,2 J. Maltzman.1,3

    1Stanford University, Palo Alto; 2University of Pennsylvania, Philadelphia; 3Veterans Administration Medical Center, Palo Alto.

    Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…
  • 2016 American Transplant Congress

    Neuro-invasive Saint Louis Encephalitis Virus (SLEV) Infection in Solid Organ Transplant Recipients in a Non-Endemic Area.

    C. Hartmann, I. Qaqish, T. Grys, H. Vikram, M. Seville, R. Orenstein, S. Kusne, J. Blair, R. Patron.

    Infectious Disease, Mayo Clinic Arizona, Phoenix, AZ.

    Background:In the summer of 2015, three prior solid organ transplant recipients developed meningoencephalitis suggestive of West Nile virus (WNV) infection in the Phoenix area with…
  • 2016 American Transplant Congress

    Clinical, Histologic and Charge Endpoints When Populations with Hepatitis C Recurrence Are Treated with Direct-Acting Antiviral or Interferon Based Therapies.

    S. Olson, A. McCann, S. Kumer, T. Schmitt, B. Floyd, R. Taylor, R. Gilroy.

    University of Kansas, Kansas City, KS.

    Background: While the primary endpoint for patients transplanted for Hepatitis C (HCV) has been established as sustained virologic response (SVR), different pathways have existed to…
  • 2016 American Transplant Congress

    Evaluation of a Novel Global Immunity Assay to Predict Infections in Organ Transplant Recipients.

    M. Mian, A. Humar, S. Keshwani, S. Husain, P. Ashton, S. Han, L. Singer, J. Kim, E. Renner, M. Bhat, D. Kumar.

    Multi-Organ Transplant, University Health Network, Toronto, Canada.

    BackgroundSimple standardized measures of global immunity may help predict the risk of infections post-transplant. The Quantiferon-Monitor (QFM) test is a novel interferon-γ (IFN-γ) release assay…
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