2019 American Transplant Congress
IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new transplant immunosuppression strategy offering improved long-term patient and allograft survival without the nephrotoxicity of calcineurin inhibitors. However,…2019 American Transplant Congress
The Immunomodulatory Role of Type I Interferons in Alloimmunity
Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…2018 American Transplant Congress
Characterization of Mycobacterium Tuberculosis Memory T Cell Subsets in Solid Organ Transplant Recipients with Previously Treated Active Tuberculosis
Introduction:Cell-mediated immune (CMI) responses including CD4+ and CD8+ T-cells contribute to control of Mycobacterium tuberculosis (MTb) infection. There are no data on long term TB-specific…2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…2018 American Transplant Congress
Recipient IFNAR1 Signaling Supports Costimulation Independent Rejection by Promoting T Cell Activation
Department of Surgery, Emory University, Atlanta, GA.
Costimulation blockade (CoB) is a promising strategy for more targeted/less toxic transplant immunosuppression which has led to the first improvement in long-term outcomes for transplant…2018 American Transplant Congress
Interferon-b Promotes Regulatory T Cell (Treg) Induction and Prolongs Allograft Survival
Background: Interferon-b (IFNb), a type I interferon with antiviral and pro-inflammatory activity, has been used as an immune modulatory treatment of multiple sclerosis (MS). The…2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…2017 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.
Plastic Surgery, Johns Hopkins University. School of Medicine, Baltimore, MD
PurposeA growing body of experimental evidence shows that engagement of toll like receptors (TLR) can abrogate or revert the tolerogenic effect of “costimulation blockade” in…
American Transplant Congress abstracts