2020 American Transplant Congress
AIPCs Home to and Engraft in the Pancreas When Injected Intravenously
1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…2020 American Transplant Congress
Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications
*Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…2019 American Transplant Congress
Donor Insulin Therapy Predicts Better Graft Survival in Pancreas Transplantation
University of Manchester, Manchester, United Kingdom
*Purpose: Organ donors frequently develop hyperglycaemia in intensive care, which is managed with insulin. In islet and solid pancreas transplantation (PT) we reported that Donor…2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…2019 American Transplant Congress
Assessment of Culture/Preservation Conditions on Survival and Function of Islets
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: Culture or preservation of human islets prior to transplantation has been adopted by various centers because it may reduce immunogenicity, suppress exocrine contamination and…2019 American Transplant Congress
Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function
*Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…2019 American Transplant Congress
Insulin Treatment in Pancreas Donors on the Intensive Care is a Marker of Beta Cell Death as Evidenced by microRNA Data
University of Manchester, Manchester, United Kingdom
*Purpose: We showed in prior studies that donor insulin use on intensive care predicts early beta cell dysfunction in islet and solid pancreas transplantation. We…2019 American Transplant Congress
Kidney Transplantation after Sleeve Gastrectomy in the Morbidly Obese Candidate: Results of a Five-Year Experience
Department of Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Morbid obesity serves as a barrier to kidney transplantation (KT) due to potential suboptimal post-transplant outcomes. Laparoscopic sleeve gastrectomy (LSG) has previously been shown…2019 American Transplant Congress
Outcomes of Total Pancreatectomyand Islet Autotransplantation, a Single Center Experience
*Purpose: Patients with chronic pancreatitis (CP) suffer from severe pain that greatly reduces their quality of life and often leads to long-term narcotic therapy to…2019 American Transplant Congress
Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index
*Purpose: This study was performed to verify post-transplant improvement of functioning β-cell mass and insulin sensitivity of functioning pancreas transplants according to the degree of…
American Transplant Congress abstracts