Articles tagged "Inflammation"

2019 American Transplant Congress
Expansion of Myeloid Derived Suppressor Cells Following Alum Administration
A. G. Cuenca, N. J. Feeney, K. Deng, C. G. Rickert, J. F. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: Immunosuppressive medications, such as calcineurin inhibitors, are critical to the survival of the transplant allograft but come with significant morbidity to the recipient and…
2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹
¹Yale University, New Haven, CT, ²University of Toronto, Toronto, ON, Canada, ³Columbia University, New York, NY
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
2019 American Transplant Congress
Monitoring Inflammatory Cytokine Levels in Kidney Transplant Patients (KTx Pts) with Chronic Antibody Mediated Rejection (cABMR) Treated with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody)
S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², S. C. Jordan², X. Zhang³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a pro-inflammatory cytokine involved in KTx rejection. A clinical trial to improve cABMR using CLZ in HLA-sensitized KTx Pts is underway. Inhibition…
2019 American Transplant Congress
Interstitial CD68+ Cells Infiltration and Kidney Graft Outcome
E. Paoletti¹, E. Bussalino², L. Marsano¹, D. Bellino¹, R. Russo¹, A. Parodi¹, G. Garibotto², J. L. Ravetti³
¹Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, ²Nephrology, Dialysis, and Transplantation, University of Genoa, Genova, Italy, ³Pathology, Policlinico San Martino Genova, Genova, Italy
*Purpose: Macrophage infiltration, as an expression of early inflammation, is associated with unfavorable kidney graft outcome in protocol biopsies. However, few studies have evaluated the…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
Phosphoproteomic Analysis of Mouse Hepatic Ischemia/Reperfusion Injury
A. Zarrinpar,² S. Duarte,¹ Y. Lai.²
¹Surgery, University of California, Los Angeles, CA; ²Surgery, University of Florida, Gainesville, FL.
Introduction: Hepatic ischemia/reperfusion injury (IRI) is a major risk factor for acute rejection and early graft dysfunction in liver transplantation. The large and complex landscape…
2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Y. Liu, Y. Dong, D. Mathews, A. Ghosh, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…
2018 American Transplant Congress
Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation
R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
2018 American Transplant Congress
Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury
N. Valenzuela.
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…