Articles tagged "Inflammation"

2019 American Transplant Congress
Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance
M. Iglesias Lozano, M. Chicco, D. Bibicheff, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…
2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
CHOP Deficiency Attenuated Acute Liver Injury by Promoting Macrophage M2 Polarization via ATG5-Mediated Autophagy Activation
H. Zhou, R. Liu, Q. Wang, C. Shi, F. Cheng, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Critical roles of CCAAT-Enhancer-Binding Protein Homologous Protein (CHOP) have been found in mediating acute liver injury. The aim of this study is to determine…
2019 American Transplant Congress
Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal
Department of Surgery, University of Maryland, Baltimore 21201, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
2019 American Transplant Congress
Post-Reperfusion Hepatic Beta-Catenin Activation Regulates Graft Damage, Inflammatory Responses and Transplant Outcomes
H. Hirao, K. Kadono, S. Kageyama, K. Nakamura, T. Ito, J. Aziz, K. J. Dery, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI), an innate-immune driven hepatic inflammation response, represents a major risk factor of early allograft dysfunction (EAD) and rejection in liver…
2019 American Transplant Congress
Expansion of Myeloid Derived Suppressor Cells Following Alum Administration
A. G. Cuenca, N. J. Feeney, K. Deng, C. G. Rickert, J. F. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: Immunosuppressive medications, such as calcineurin inhibitors, are critical to the survival of the transplant allograft but come with significant morbidity to the recipient and…
2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹
¹Yale University, New Haven, CT, ²University of Toronto, Toronto, ON, Canada, ³Columbia University, New York, NY
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
2019 American Transplant Congress
Monitoring Inflammatory Cytokine Levels in Kidney Transplant Patients (KTx Pts) with Chronic Antibody Mediated Rejection (cABMR) Treated with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody)
S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², S. C. Jordan², X. Zhang³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a pro-inflammatory cytokine involved in KTx rejection. A clinical trial to improve cABMR using CLZ in HLA-sensitized KTx Pts is underway. Inhibition…
2019 American Transplant Congress
Interstitial CD68+ Cells Infiltration and Kidney Graft Outcome
E. Paoletti¹, E. Bussalino², L. Marsano¹, D. Bellino¹, R. Russo¹, A. Parodi¹, G. Garibotto², J. L. Ravetti³
¹Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, ²Nephrology, Dialysis, and Transplantation, University of Genoa, Genova, Italy, ³Pathology, Policlinico San Martino Genova, Genova, Italy
*Purpose: Macrophage infiltration, as an expression of early inflammation, is associated with unfavorable kidney graft outcome in protocol biopsies. However, few studies have evaluated the…
2019 American Transplant Congress
Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients
T. J. Borges¹, J. T. O’Malley², B. Kollar³, B. Pomahac³, S. G. Talbot³, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Plastic Surgery, Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…