Articles tagged "Inflammation"

2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
Alteration in Local Complement Activation in First 24h Post-Lung Transplantation (LTx) Helps Identify Recipients Developing Primary Graft Dysfunction
H. Kulkarni¹, M. Elvington², L. Ma¹, M. Cano¹, K. Pugh³, R. Hachem¹, J. Atkinson², A. Gelman³
¹Pulmonary and Critical Care Medicine, Washington University, Saint Louis, MO, ²Rheumatology, Washington University, Saint Louis, MO, ³Surgery, Washington University, Saint Louis, MO
*Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically…
2019 American Transplant Congress
Novel Insights into Blocking the IL-6 / IL-6 Receptor Pathway after Pig Kidney Xenotransplantation in Baboons
H. Hara¹, G. Zhang¹, H. Iwase¹, T. Yamamoto¹, D. Ayares², D. E. Eckhoff¹, D. K. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor Inc., Blacksburg, VA
*Purpose: IL-6 plays an important role in inflammation. The aims of the study were (i) to measure IL-6 in serum in baboons that received IL-6…
2019 American Transplant Congress
Urinary Injury Biomarkers in Deceased Donors and Acute Rejection Post Kidney Transplant
P. Reese¹, I. Hall², S. Mohan³, H. Theissen-Philbrook⁴, Y. Jia⁴, M. Doshi⁵, J. Bromberg⁶, S. Mansour⁷, M. Harhay⁸, F. Weng⁹, E. Akalin¹⁰, C. Parikh⁴
¹UPENN, Philadelphia, PA, ²Univ of Utah, Salt Lake City, UT, ³Columbia, NY, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵Univ of Michigan, Ann Arbor, MI, ⁶Univ of Maryland, Baltimore, MD, ⁷Yale, New Haven, CT, ⁸Drexel, Philadelphia, PA, ⁹St. Barnabas, Philadelphia, PA, ¹⁰Montefiore, NY, NY
*Purpose: Acute kidney injury (AKI) is common among deceased kidney donors. We hypothesized that inflammation from kidney injury could lead to enhanced expression of HLA…
2019 American Transplant Congress
Assessment of Culture/Preservation Conditions on Survival and Function of Islets
Y. Shindo, M. F. Levy, M. A. Kanak
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: Culture or preservation of human islets prior to transplantation has been adopted by various centers because it may reduce immunogenicity, suppress exocrine contamination and…
2019 American Transplant Congress
Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury
J. Kim¹, J. Park², K. Yoo², J. Moon¹, J. Jeong¹, C. Lee³, Y. Kim¹, S. Yang⁴
¹Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, ³Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of
*Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…
2019 American Transplant Congress
Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation
H. Iwase¹, A. Jagdale¹, T. Yamamoto¹, G. Zhang¹, Q. Li¹, J. Foote¹, D. Ayares², H. Hara¹, D. K. Cooper¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Inc., Blacksburg, VA
*Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
2019 American Transplant Congress
Islet Stress Leads to Increased Release of Exosomes That Stimulate Immune Cell Response
S. Vasu¹, C. Darden², K. Kumano¹, B. Naziruddin³, M. Lawrence³
¹Baylor Scott and White Research Institute, Dallas, TX, ²Institute of Biomedical Studies, Baylor University, Waco, TX, ³Baylor University Medical Ctr, Dallas, TX
*Purpose: Islet dysfunction and death caused by isolation procedures, immune attack and hypoxia significantly affect islet transplantation outcomes. Non-invasive monitoring of islet stress and damage…
2019 American Transplant Congress
Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition
H. ZHOU, Q. Wang, R. Liu, S. Zhou, F. Cheng, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…