Articles tagged "Inflammation"

2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹
¹Yale University, New Haven, CT, ²University of Toronto, Toronto, ON, Canada, ³Columbia University, New York, NY
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
2019 American Transplant Congress
Monitoring Inflammatory Cytokine Levels in Kidney Transplant Patients (KTx Pts) with Chronic Antibody Mediated Rejection (cABMR) Treated with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody)
S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², S. C. Jordan², X. Zhang³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a pro-inflammatory cytokine involved in KTx rejection. A clinical trial to improve cABMR using CLZ in HLA-sensitized KTx Pts is underway. Inhibition…
2019 American Transplant Congress
Interstitial CD68+ Cells Infiltration and Kidney Graft Outcome
E. Paoletti¹, E. Bussalino², L. Marsano¹, D. Bellino¹, R. Russo¹, A. Parodi¹, G. Garibotto², J. L. Ravetti³
¹Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, ²Nephrology, Dialysis, and Transplantation, University of Genoa, Genova, Italy, ³Pathology, Policlinico San Martino Genova, Genova, Italy
*Purpose: Macrophage infiltration, as an expression of early inflammation, is associated with unfavorable kidney graft outcome in protocol biopsies. However, few studies have evaluated the…
2019 American Transplant Congress
Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients
T. J. Borges¹, J. T. O’Malley², B. Kollar³, B. Pomahac³, S. G. Talbot³, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Plastic Surgery, Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…
2019 American Transplant Congress
Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury
S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…
2019 American Transplant Congress
Microcirculation Inflammation with TCMR is Associated with Poor Graft Outcomes in Kidney Transplant Recipients (KTRs) without ABMR
A. Cherukuri, S. Tandukar, S. Hariharan, R. Mehta
UPMC, Pittsburgh, PA
*Purpose: Glomerulitis (g) and peritubular capillaritis (ptc), defined as microcirculation inflammation lesions (MI), are a hallmark of ABMR in KTRs. Their significance in KTRs with…
2019 American Transplant Congress
Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury
S. Kageyama¹, H. Hirao¹, K. Kadono¹, K. Nakamura¹, K. J. Dery¹, T. Ito², D. Oncel¹, J. Aziz¹, B. Ke¹, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec‐Weglinski¹
¹Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…
2019 American Transplant Congress
Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage
J. Lion¹, K. Poussin¹, E. Chong², D. Glotz³, N. A. Mooney¹
¹Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, ²Vitaeris, Vancouver, BC, Canada, ³Nephrology and Transplantation, Hôpital Saint Louis, Paris, France
*Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
2019 American Transplant Congress
Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat Livers
U. Scheuermann, E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, M. Hartwig, J. Kwun, J. Lee, A. S. Barbas
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Donor age is one of the most important predictive factors of graft outcome in liver transplantation. The aim of this study was to investigate…
2019 American Transplant Congress
Outcomes of Phenotypes in Early Subclinical Inflammation (SCI) Determined by Presence of Interstitial Inflammation with or without Concomitant Tubulitis
R. Mehta, S. Tandukar, D. Jorgensen, I. Owoyemi, P. Sood, A. Tevar, S. Hariharan
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Low levels of renal allograft inflammation in the early post transplant period appear to have an impact on renal architecture and function. However, the…