Articles tagged "Inflammation"

2019 American Transplant Congress
Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat Livers
U. Scheuermann, E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, M. Hartwig, J. Kwun, J. Lee, A. S. Barbas
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Donor age is one of the most important predictive factors of graft outcome in liver transplantation. The aim of this study was to investigate…
2019 American Transplant Congress
Outcomes of Phenotypes in Early Subclinical Inflammation (SCI) Determined by Presence of Interstitial Inflammation with or without Concomitant Tubulitis
R. Mehta, S. Tandukar, D. Jorgensen, I. Owoyemi, P. Sood, A. Tevar, S. Hariharan
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Low levels of renal allograft inflammation in the early post transplant period appear to have an impact on renal architecture and function. However, the…
2019 American Transplant Congress
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
D. Jane-wit¹, C. Fang¹, L. Liu¹, L. Qin¹, G. Guangxin Li¹, P. Nigrovic², G. Tellides³, J. Pober⁴
¹Dept of Cardiology, Yale University School of Medicine, New Haven, CT, ²Dept of Rheumatology, Immunology, and Allergy, Harvard University, Boston, MA, ³Dept of Surgery, Yale University School of Medicine, New Haven, CT, ⁴Dept of Immunobiology, Yale University School of Medicine, New Haven, CT
*Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…
2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
2019 American Transplant Congress
The Crucial Role of Molecular Microscope in the Interpretation of Ambiguous Lesions Such as Banff Borderline Changes and Tubulo-Interstitial Inflammation Accompanying PVAN
D. Deborska-Materkowska¹, A. Perkowska-Ptasinska¹, M. Ciszek¹, P. F. Halloran², M. Myslak³
¹Warsaw Medical University, Warsaw, Poland, ²ATAGC, University of Alberta, Edmonton AB, AB, Canada, ³Pomeranian Medical University, Szczecin, Poland
*Purpose: Anti-rejection treatment implementation is highly dependent on morphologic lesions interpretation based on Banff classification. Unfortunately, some light microscopic phenotypes are ambiguous which constricts the…
2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
S. Lee, S. Noel, J. Kurzhagen, M. Sadasivam, A. Hamad, H. Rabb
Johns Hopkins, Baltimore, MD
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?
K. D. Bera¹, J. Tabak², M. L. Lo Faro¹, R. J. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University of Exeter, Exeter, United Kingdom
*Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Rejection and Antibody Mediated Rejection within the First Year after Kidney Transplantation
I. Owoyemi, D. Jorgensen, S. Tandukar, R. Mehta, S. Hariharan
Thomas E. Starzl Institute of Transplantation and Division of Transplant Nephrology, UPMC, Pittsburgh, PA
*Purpose: This study evaluated the impact of Clinical and Sub-clinical T-Cell-Mediated Rejection (TCMR), Sub-Clinical Inflammation and Antibody Mediated Rejection (ABMR) within the 1st year post-kidney…