Articles tagged "Inflammation"

2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation
H. Yang¹, L. Luo¹, X. Li¹, C. Long¹, Y. Shi², Y. Xiong³, M. Chen⁴, J. Gao⁵, H. Li⁶, Z. Wang⁶
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, ⁶Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…
2019 American Transplant Congress
Effect of Paricalcitol on Markers of Inflammation in De Novo Renal Transplant Recipients
H. K. Pihlstrøm¹, T. Ueland², A. E. Michelsen², G. Mjøen¹, K. Midtvedt¹, H. Holdaas¹
¹Department of Surgery, Inflammation Medicine and Transplantation, Oslo University Hospital, Oslo, Norway, ²Institiute for Clinical Medicine, University of Oslo, Oslo, Norway
*Purpose: Despite the reduction of systemic inflammation associated with receiving a functioning transplant, markers of inflammation may remain somewhat elevated in renal transplant recipients, and…
2019 American Transplant Congress
Myeloid AXL Promotes Cardiac Allograft Vasculopathy
K. E. Glinton¹, X. Yeap¹, Z. J. Zhang², X. Luo³, E. B. Thorp¹
¹Pathology, FCVRRI, Northwestern University - Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University - Feinberg School of Medicine, Chicago, IL, ³Duke Transplant Center, Duke University School of Medicine, Durham, NC
*Purpose: Cardiac Allograft Vasculopathy (CAV) is a significant contributor to long term transplant rejection, despite advances in immunotherapy. Reactivity to alloantigen presentation may occur by…
2019 American Transplant Congress
Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury
Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…
2019 American Transplant Congress
Eupatilin Ameliorates Tacrolimus Induced Nephrotoxicity via Inhibiting Apoptosis
H. J. Jang, C. S. Park, M. Y. Oh
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2019 American Transplant Congress
High Prevalence of De Novo Donor-Specific Antibodies during Rejection after Liver Transplantation
J. Colmenero, N. Flores, A. Diaz, M. Vasquez, P. Ruiz, G. Crespo, J. Martorell, M. Navasa
Liver Transplant Unit, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Anti-HLA donor specific antibodies (dnDSA) after liver transplantation (LT) are currently under investigation. Recent studies show an incidence of dnDSA after LT ranging from…
2019 American Transplant Congress
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
A. Bajwa¹, V. Bontha¹, C. Kuscu¹, L. Gallon², C. Kuscu¹, J. Eason³, D. Maluf¹, V. Mas⁴
¹UTHSC, Memphis, TN, ²Northwestern University, Chicago, IL, ³Director Transplant Institute, Memphis, TN, ⁴Director Transplant Reserach Institute, Memphis, TN
*Purpose: FTY720, a S1PR agonist has been shown to protect kidneys from IRI. However, systemic use is limited due to adverse side effects. Dendritic cells…
2019 American Transplant Congress
Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis
M. Ni¹, H. Wang¹, D. Jin¹, J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a clinical problem associated with both surgical and non-surgical settings. Innate immune-dominated inflammation drives the pathogenesis of liver…
2019 American Transplant Congress
Targeting Pyroptosis in Brain-Dead Donors Improves Renal Function after Transplantation in Rat
H. Yang¹, Y. Shi², X. Li¹, L. Luo¹, C. Long¹, Y. Xiong³, M. Chen⁴, J. Gao⁴, H. Li⁵, Z. Wang⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Pyroptosis is a form of programmed cell death include necrosis, nuclear condensation, and release of proinflammatory after caspase-1 activation. It is unknown whether pyroptosis…