Articles tagged "Inflammation"

2020 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury
J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2020 American Transplant Congress
Type 3 Innate Lymphoid Cells Are Associated with a Successful Intestinal Transplant
J. Kang¹, K. Loh¹, L. Belyayev¹, S. Moturi¹, M. Sadat¹, K. Khan¹, A. Duttargi¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom², J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and tissue homeostasis. We hypothesized that protective IL-22-producing NKp44+ILC3 subsets are reduced under…
2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
J. Leeds¹, Y. Scindia², E. Ghias¹, S. Cechova¹, V. Loi¹, E. Mandziak¹, S. Swaminathan¹
¹University of Virginia, Charlottesville, VA, ²University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, K. Loh, J. Green, M. Sadat, M. Stovroff, A. Duttargi, B. Kallakury, K. Khan, T. Fishbein, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…
2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
E. Cervantes-Alvarez¹, F. Tejeda-Dominguez², M. Lizardo-Thiebaud², E. Alatorre-Arenas³, O. Méndez-Guerrero¹, S. Yarza-Regalado¹, D. Kershenobich¹, A. Torre¹, M. Vilatobá⁴, C. A. Huang⁵, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, ³University of the Americas Puebla, School of Medicine, Puebla, Mexico, ⁴Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Surgery, University of Colorado Anschutz Medical Campus, Denver, CO
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
J. Li, N. Rogers, S. Alexander
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
2020 American Transplant Congress
Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation
B. I. Shaw¹, H. Lee², C. Chan², R. B. Ettenger³, P. Grimm⁴, E. F. Reed⁵, M. Sarwal⁶, L. Stempora¹, B. Warshaw⁷, O. M. Martinez⁸, A. D. Kirk¹, E. T. Chambers⁹
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, University of California, Los Angeles, Los Angeles, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Pathology, University of California, Los Angeles, Los Angeles, CA, ⁶Surgery, University of California, San Francisco, San Francisco, CA, ⁷Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA, ⁸Surgery, Stanford University, Palo Alto, CA, ⁹Pediatrics, Duke University, Durham, NC
*Purpose: Nutritional status is known to modulate immunologic responses in non-immunosuppressed individuals. We utilized the Immune Development in Pediatric Transplantation (IMPACT) study to assess differences…
2020 American Transplant Congress
Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium
L. G. Bracaglia¹, T. Lysyy², L. Qin², C. Albert¹, J. S. Pober², G. Tellides², W. M. Saltzman¹, G. T. Tietjen²
¹Yale University, New Haven, CT, ²Yale School of Medicine, New Haven, CT
*Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…