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American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2020 American Transplant Congress

    CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury

    M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA

    *Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…
  • 2020 American Transplant Congress

    TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury

    H. Zhou, S. Zhou, Q. Wang, Z. Rao, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…
  • 2020 American Transplant Congress

    Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death

    S. Toldo, E. Mezzaroma, M. Quader

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…
  • 2020 American Transplant Congress

    Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation

    N. Chu, C. Haugen, D. Segev, M. McAdams-DeMarco

    Johns Hopkins, Baltimore, MD

    *Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…
  • 2020 American Transplant Congress

    Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury

    Z. Wang1, A. B. Harrant1, Y. Wang1, K. Washington1, E. Farkash2, C. A. Huang1

    1Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 2Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
  • 2020 American Transplant Congress

    Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation

    J. M. Janjic1, E. Lambert1, L. Liu1, M. Herneisey1, V. S. Gorantla2

    1School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, 2Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC

    *Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
  • 2020 American Transplant Congress

    Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates

    C. Blanton1, J. Reyes1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. vanAmersfoort2, J. Torrealba3, Y. Yankol1, A. D’Alessandro1, L. Fernandez1

    1University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UTSouthwestern, Dallas, TX

    *Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
  • 2020 American Transplant Congress

    Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model

    G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama

    Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    *Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
  • 2020 American Transplant Congress

    DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions

    R. G. Bardallo1, R. G. Teixeira-Silva2, A. Panisello-Rosello3, E. Folch-Puy3, J. Rosello Catafau4, T. Carbonell5

    1Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain, 2Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, CSIC, Barcelona, Spain, 3Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, 4Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain, 5Cell Biology, Physiollogy and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    *Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…
  • 2020 American Transplant Congress

    IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions

    T. Li1, Z. Zhang1, Q. Liu1, J. Bartolacci2, M. Velayutham1, G. Hussey2, J. Dziki2, L. Mathews1, Y. Lee3, G. Dwyer1, H. Dai1, A. Roessing1, S. Shiva4, M. Oberbarnscheidt1, S. Badylak2, H. Turnquist1

    1Starzl Transplant Inst. and Dept. Surgery, University of Pittsburgh, Pittsburgh, PA, 2McGowan Inst. and Dept. of Surgery, University of Pittsburgh, Pittsburgh, PA, 3Bioengineering, University of Pittsburgh, Pittsburgh, PA, 4Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…
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