Articles tagged "Inflammation"

2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Rejection – Molecular Rebound Phenomena Under IL-6 Blockade?
A. Borski¹, S. Haindl², M. Duerr³, K. Budde³, S. Schranz¹, F. A. Eskandary², K. Doberer², P. F. Halloran⁴, E. Chong⁵, B. Jilma¹, G. A. Böhmig², M. Wahrmann²
¹Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Vitaeris Inc., Vancouver, BC, Canada
*Purpose: Late antibody-mediated rejection (ABMR) is well established as a major cause of kidney allograft failure. Targeting interleukin-6 (IL-6), a pro-inflammatory cytokine involved in B…
2020 American Transplant Congress
Sex-Dependent Resistance to Ischemia-Reperfusion Injury in Mouse and Human Liver Transplantation
S. Kageyama, H. Kojima, K. Kadono, H. Hirao, K. J. Dery, S. Younan, T. Ito, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for early allograft dysfunction and rejection in orthotopic liver transplantation (OLT). The influence of sex on…
2020 American Transplant Congress
Dual and Opposite Costimulatory Targeting with a Novel Hybrid Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury in a Rat Bilateral Kidney Model
J. Guiteras¹, L. De Ramon¹, E. Crespo¹, N. Bolaños¹, P. Fontova¹, M. Jarque¹, A. Torija¹, O. Bestard², J. Grinyó², J. Torras²
¹Experimental Nephrology, IDIBELL, Hospitalet de Llobregat, Spain, ²Bellvitge University Hospital, Hospitalet de Llobregat, Spain
*Purpose: Many studies showed the CTLA4 effectiveness in the inhibition of CD28-CD80/86 costimulatory pathway in transplant and autoimmune diseases. Furthermore, the PD1-PDL1/2 interaction has been…
2020 American Transplant Congress
A NASHional Crisis: Liver Transplantation Outcomes in Female Hispanics
R. A. Sosa¹, A. Q. Terry¹, M. Rossetti¹, F. M. Kaldas², B. V. Naini¹, J. Nevarez-Mejia¹, V. M. Groysberg¹, S. Younan², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski², E. F. Reed¹
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²Surgery, UCLA, Los Angeles, CA
*Purpose: Obesity and metabolic syndrome have recently become an epidemic with Hispanics bearing a disproportionate burden. Non-alcoholic steatohepatitis (NASH) is a severe immune-mediated stage of…
2020 American Transplant Congress
Microbiota Modulates Ischemia-Reperfusion Injury in Mouse Liver Transplantation
S. Kageyama¹, H. Kojima¹, K. Kadono¹, H. Hirao¹, K. J. Dery¹, K. Nakamura², T. Dong³, J. Jacobs³, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Nishi Kobe Medical Center, Kobe, Japan, ³The Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor in orthotopic liver transplantation (OLT). As host microbiota may associate with health or disease, antibiotics (Abx)…
2020 American Transplant Congress
Interstitial Inflammation with Chronic Allograft Injury Best Predicts Graft Loss
M. Ajaimy, M. Parides, A. Colovai, Y. Azzi, L. Liriano Ward, P. Nandigam, J. Rocca, M. Kinkhabwala, S. Greenstein, J. Graham, E. Akalin
Einstein-Montefiore Transplant Center, Bronx, NY
*Purpose: We aimed to identify clinical, serological and histopathological predictors of graft loss in kidney transplant recipients who underwent clinically indicated graft biopsies for worsening…
2020 American Transplant Congress
Acute Respiratory Distress Syndrome in a Simultaneous Kidney/Pancreas Transplant Recipient after “Dabbing” with Marijuana Rosin: A Case Report
M. Baska¹, H. Kerr², K. Eid², K. Gabrys³, I. Khan⁴, M. Quraishi⁴, F. Barrantes³
¹Burrell College of Osteopathic Medicine, Las Cruces, NM, ²Presbyterian Healthcare Services, Albuquerque, NM, ³Renal Medicine Associates, Presbyterian Healthcare Services, Albuquerque, NM, ⁴Pediatric Critical Care Medicine, Presbyterian Healthcare Services, Albuquerque, NM
*Purpose: Acute Respiratory Distress is a high-risk complication of lung inflammation that has been linked to multiple exogenous agents.*Methods: We present the case of a…
2020 American Transplant Congress
The Pro-Inflammatory Profile of Alcoholic Patients Increases Risk for Ischemia-Reperfusion Injury During Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, M. Rossetti¹, F. Li¹, J. Nevarez-Mejia¹, B. V. Naini¹, F. M. Kaldas², V. M. Groysberg¹, S. M. Younan², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski³, E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Department of Surgery, UCLA, Los Angeles, CA, ³Departments of Pathology and Laboratory Medicine and Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which triggers a pro-inflammatory immune response that can lower allograft survival in orthotopic liver transplant (OLT) patients. In…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…