Articles tagged "Inflammation"

2020 American Transplant Congress
CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…
2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
H. Zhou, S. Zhou, Q. Wang, Z. Rao, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…
2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
S. Toldo, E. Mezzaroma, M. Quader
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…
2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
N. Chu, C. Haugen, D. Segev, M. McAdams-DeMarco
Johns Hopkins, Baltimore, MD
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…
2020 American Transplant Congress
Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury
Z. Wang¹, A. B. Harrant¹, Y. Wang¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
C. Blanton¹, J. Reyes¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. vanAmersfoort², J. Torrealba³, Y. Yankol¹, A. D’Alessandro¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UTSouthwestern, Dallas, TX
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
2020 American Transplant Congress
Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model
G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama
Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
*Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
2020 American Transplant Congress
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
R. G. Bardallo¹, R. G. Teixeira-Silva², A. Panisello-Rosello³, E. Folch-Puy³, J. Rosello Catafau⁴, T. Carbonell⁵
¹Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain, ²Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, CSIC, Barcelona, Spain, ³Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, ⁴Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain, ⁵Cell Biology, Physiollogy and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain
*Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…
2020 American Transplant Congress
IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions
T. Li¹, Z. Zhang¹, Q. Liu¹, J. Bartolacci², M. Velayutham¹, G. Hussey², J. Dziki², L. Mathews¹, Y. Lee³, G. Dwyer¹, H. Dai¹, A. Roessing¹, S. Shiva⁴, M. Oberbarnscheidt¹, S. Badylak², H. Turnquist¹
¹Starzl Transplant Inst. and Dept. Surgery, University of Pittsburgh, Pittsburgh, PA, ²McGowan Inst. and Dept. of Surgery, University of Pittsburgh, Pittsburgh, PA, ³Bioengineering, University of Pittsburgh, Pittsburgh, PA, ⁴Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…