Articles tagged "Inflammation"

2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, K. Loh, J. Green, M. Sadat, M. Stovroff, A. Duttargi, B. Kallakury, K. Khan, T. Fishbein, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…
2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
E. Cervantes-Alvarez¹, F. Tejeda-Dominguez², M. Lizardo-Thiebaud², E. Alatorre-Arenas³, O. Méndez-Guerrero¹, S. Yarza-Regalado¹, D. Kershenobich¹, A. Torre¹, M. Vilatobá⁴, C. A. Huang⁵, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, ³University of the Americas Puebla, School of Medicine, Puebla, Mexico, ⁴Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Surgery, University of Colorado Anschutz Medical Campus, Denver, CO
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
J. Li, N. Rogers, S. Alexander
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
2020 American Transplant Congress
Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation
B. I. Shaw¹, H. Lee², C. Chan², R. B. Ettenger³, P. Grimm⁴, E. F. Reed⁵, M. Sarwal⁶, L. Stempora¹, B. Warshaw⁷, O. M. Martinez⁸, A. D. Kirk¹, E. T. Chambers⁹
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, University of California, Los Angeles, Los Angeles, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Pathology, University of California, Los Angeles, Los Angeles, CA, ⁶Surgery, University of California, San Francisco, San Francisco, CA, ⁷Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA, ⁸Surgery, Stanford University, Palo Alto, CA, ⁹Pediatrics, Duke University, Durham, NC
*Purpose: Nutritional status is known to modulate immunologic responses in non-immunosuppressed individuals. We utilized the Immune Development in Pediatric Transplantation (IMPACT) study to assess differences…
2020 American Transplant Congress
Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium
L. G. Bracaglia¹, T. Lysyy², L. Qin², C. Albert¹, J. S. Pober², G. Tellides², W. M. Saltzman¹, G. T. Tietjen²
¹Yale University, New Haven, CT, ²Yale School of Medicine, New Haven, CT
*Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
2020 American Transplant Congress
Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation
S. Raza, G. Agarwal, D. Anderson, M. Deierhoi, H. Fatima, M. Hanaway, J. Locke, P. MacLennan, B. Orandi, C. Young, R. Mannon, M. Seifert
University of Alabama School of Medicine, Birmingham, AL
*Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…
2020 American Transplant Congress
Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², Y. Guo², B. Oh², G. Brandacher², J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…