Articles tagged "Inflammation"

2020 American Transplant Congress
The Pro-Inflammatory Profile of Alcoholic Patients Increases Risk for Ischemia-Reperfusion Injury During Orthotopic Liver Transplantation
A. Q. Terry¹, R. A. Sosa¹, M. Rossetti¹, F. Li¹, J. Nevarez-Mejia¹, B. V. Naini¹, F. M. Kaldas², V. M. Groysberg¹, S. M. Younan², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski³, E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Department of Surgery, UCLA, Los Angeles, CA, ³Departments of Pathology and Laboratory Medicine and Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which triggers a pro-inflammatory immune response that can lower allograft survival in orthotopic liver transplant (OLT) patients. In…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
2020 American Transplant Congress
The Reperfusion Response in Plasma of Combined Heart/ Lung Transplanted Patients is Guided by Heart-Associated Cytokine Patterns on Contrast to the Ischemic Injury in Perfusion Solutions Following a Lung-Associated Pattern
C. Falk¹, J. Kühne², L. Radomsky², F. Wandrer², B. Wiegmann³, N. Ledwoch², J. Keil², K. Beushausen², F. Ius³, W. Sommer³, S. Rojas-Hernandez³, I. Tudorache³, A. Haverich³, G. Warnecke³
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ³Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation but rarely compared directly in a clinical setting. Therefore, we compared a cohort…
2020 American Transplant Congress
The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation
E. Van Loon, M. Coemans, A. Senev, D. Kuypers, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…
2020 American Transplant Congress
CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…
2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
H. Zhou, S. Zhou, Q. Wang, Z. Rao, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…
2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
S. Toldo, E. Mezzaroma, M. Quader
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…
2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
N. Chu, C. Haugen, D. Segev, M. McAdams-DeMarco
Johns Hopkins, Baltimore, MD
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…
2020 American Transplant Congress
Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury
Z. Wang¹, A. B. Harrant¹, Y. Wang¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…