2020 American Transplant Congress
Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection
Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…2020 American Transplant Congress
Proinflammatory Cytokines Including IL-18 Correlate with Cytomegalovirus DNAemia in Solid Organ Transplant Recipients
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD
*Purpose: Human cytomegalovirus (CMV) is a common immunomodulatory virus that still causes significant morbidity and mortality in solid organ transplant (SOT) recipients despite prophylaxis. Cytokines…2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…2020 American Transplant Congress
Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients
*Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…2020 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…2020 American Transplant Congress
Type 3 Innate Lymphoid Cells Are Associated with a Successful Intestinal Transplant
1MedStar Georgetown Transplant Institute, Washington, DC, 2Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and tissue homeostasis. We hypothesized that protective IL-22-producing NKp44+ILC3 subsets are reduced under…2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
1University of Virginia, Charlottesville, VA, 2University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
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