ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2020 American Transplant Congress

    Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation

    B. I. Shaw1, H. Lee2, C. Chan2, R. B. Ettenger3, P. Grimm4, E. F. Reed5, M. Sarwal6, L. Stempora1, B. Warshaw7, O. M. Martinez8, A. D. Kirk1, E. T. Chambers9

    1Surgery, Duke University, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pediatrics, University of California, Los Angeles, Los Angeles, CA, 4Pediatrics, Stanford University, Palo Alto, CA, 5Pathology, University of California, Los Angeles, Los Angeles, CA, 6Surgery, University of California, San Francisco, San Francisco, CA, 7Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA, 8Surgery, Stanford University, Palo Alto, CA, 9Pediatrics, Duke University, Durham, NC

    *Purpose: Nutritional status is known to modulate immunologic responses in non-immunosuppressed individuals. We utilized the Immune Development in Pediatric Transplantation (IMPACT) study to assess differences…
  • 2020 American Transplant Congress

    Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium

    L. G. Bracaglia1, T. Lysyy2, L. Qin2, C. Albert1, J. S. Pober2, G. Tellides2, W. M. Saltzman1, G. T. Tietjen2

    1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT

    *Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
  • 2020 American Transplant Congress

    IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance

    M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi

    Plastic Surgery, Johns Hopkins University, Baltimore, MD

    *Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
  • 2020 American Transplant Congress

    Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation

    A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal

    University of California San Francisco, San Francisco, CA

    *Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
  • 2020 American Transplant Congress

    Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation

    S. Raza, G. Agarwal, D. Anderson, M. Deierhoi, H. Fatima, M. Hanaway, J. Locke, P. MacLennan, B. Orandi, C. Young, R. Mannon, M. Seifert

    University of Alabama School of Medicine, Birmingham, AL

    *Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…
  • 2020 American Transplant Congress

    Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation

    K. Kadono1, F. Messner2, Y. Guo2, B. Oh2, G. Brandacher2, J. W. Kupiec-Weglinski1

    1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…
  • 2020 American Transplant Congress

    Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice

    A. Cuenca1, N. Feeney2, J. Ge1, K. Deng2, Q. Fu2, G. Huai2, K. Lee2, C. Rickert2, J. Markmann2

    1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…
  • 2020 American Transplant Congress

    Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection

    S. Li1, M. Song1, Q. Li2, A. Kirk1, H. Xu1

    1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC

    *Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…
  • 2020 American Transplant Congress

    Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury

    A. C. Dionne

    Microbiology and Immunology, Western University, London, ON, Canada

    *Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
  • 2020 American Transplant Congress

    Low Mycophenolic Acid Levels are Associated with More Inflammation on 1 Year Protocol Biopsies and Lower Graft Survival in Kidney Transplant Recipients

    J. Huskey, G. Mour, M. Ryan, S. Nair, M. Smith, R. Heilman

    Mayo Clinic Arizona, Phoenix, AZ

    *Purpose: Data is limited on the association of Mycophenolic Acid (MPA) concentration on protocol kidney transplant biopsies. Our aim is to compare clinical outcomes and…
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