Articles tagged "Infection"

2015 American Transplant Congress
A Prospective Pilot Study Evaluating the Safety and Efficacy of Everolimus for the Prevention of CMV and BK Viral Infection (BKV) in Broadly Sensitized Kidney Transplant Recipients Following Desensitization With IVIG and Rituximab: Interim Analysis
J. Kahwaji,¹ S. Louie,¹ A. Vo,¹ J. Choi,¹ M. Toyoda,² S. Ge,² P. Wongsaroj,¹ A. Peng,¹ R. Villicana,¹ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Transplant Immunology Lab, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Everolimus, a second generation mTOR inhibitor, may prevent CMV and BKV infection after kidney transplantation. Broadly sensitized patients are at greater risk of viral…
2015 American Transplant Congress
Improving Latent Tuberculosis Diagnosis Before Kidney Transplantation in a Developing Country
G. Meinerz,^1,2 C. da Silva,^1,2 E. Keitel,^1,2 A. Pasqualotto,³ J. Goldani,^1,2 C. Zeni,^1,4 F. Vacilotto,^1,4 N. Prado,^1,4 A. Monteiro,^2,3 D. Seelig,¹ F. Klaus,¹ J. Andrade,¹ V. Garcia.¹
¹Nephrology and Kidney Transplantation, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ²Programa de Pós-Graduação em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil; ³Laboratorio de Biologia Molecular, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ⁴Programa de Residência em Nefrologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
Introduction: Tuberculosis has shown to be a great challenge in kidney transplantation, specially in developing countries due to the difficulties in diagnosis and treatment, leading…
2015 American Transplant Congress
Preventing Cytomegalovirus Infection in Intermediate-High Risk Liver Transplant Recipients: Acyclovir Vs Valganciclovir
S. Dulanya, A. Anamisis, D. Tsapepas.
Department of Pharmacy, New York Presbyterian Hospital, New York City, NY.
Cytomegalovirus (CMV) is an opportunistic infection responsible for profound morbidity and mortality among solid organ transplant recipients. A donor and recipient's CMV IgG serostatus influences…
2015 American Transplant Congress
Screening Recipients of Increased Risk Donor Organs: A Multicenter Study
N. Theodoropoulos,¹ K. Brizendine,² M. Ison.³
¹Infectious Diseases, The Ohio State University, Columbus, OH; ²Infectious Disease, Cleveland Clinic, Cleveland, OH; ³Infectious Diseases/Organ Transplantation, Northwestern University, Chicago, IL.
Purpose: Policy mandates post-transplant (tx) evaluation of recipients of increased risk donor organs (ROIRDO). PHS guidelines recommend that screening include HIV & hepatitis C virus…
2015 American Transplant Congress
Donor and Recipient Pretransplant Polyoma BK Serostatus: Relationship to BK-Viremia After Renal Transplantation
H. Tseng, R. Lopez-Soler, N. Chandolias, T. Friedrich, J. Eldor, D. Conti.
Surgery, Albany Medical College, Albany, NY.
Background:Polyoma virus BK nephropathy is a serious complication after renal transplantation and is associated with a significant risk of graft loss and dysfunction. This study…
2015 American Transplant Congress
Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Sufficient to Prevent Donor-Specific Antibody (DSA) Formation Are Not Associated With Higher Rates of CMV/EBV/BK Viral Infections
S. Narins, D. Ladie, R. Saylor, E. Richards, H. Yang, M. Waybill.
PinnacleHealth, Harrisburg, PA.
Background: Prevention of DSA formation and antibody-mediated rejection mandates therapeutic doses of immunosuppressive agents, including MPA. We have shown that MPA AUC monitoring and dose…
2015 American Transplant Congress
Role of Universal Decolonization After Kidney Transplant: A Pilot Study
D. Lee,¹ G. Malat,² N. Law,¹ A. Sharma,¹ T. Bias,¹ K. Ranganna,¹ A. Doyle.¹
¹Department of Medicine, Drexel University, College of Medicine, Philadelphia, PA; ²Department of Surgery, Drexel University, College of Medicine, Philadelphia, PA.
IntroductionInfection is a common cause of morbidity and mortality after kidney transplantation. Despite careful pre-transplantation screening of donors and recipients, vaccination, prophylaxis, and antimicrobial use,…
2015 American Transplant Congress
The Impact of Preoperative Antimicrobial Prophylaxis on Device-Related Infections in Recipients of Long-Term Mechanical Circulatory Support (MCS)
I. El Lakkis,¹ K. Lietz,² C. Derber,¹ U. Kelly,¹ C. Wilson,¹ A. Hoedt,² P. Bourasssa,² B. Smith,² M. McGrath,² J. Herre,² M. Mooney.¹
¹Eastern Virginia Medical School, Norfolk, VA; ²Sentara Norfolk General Hospital, Norfolk, VA.
Purpose: Although preoperative antimicrobial prophylaxis is recommended for patients undergoing long-term MCS device implantation, there is a lack of consensus as to the optimal preoperative…
2015 American Transplant Congress
Donor Derived Transmission Events in 2014: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
D. Kaul,¹ S. Covington,² S. Taranto,² M. Green,¹ C. Wolfe.¹
¹OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; ²United Network for Organ Sharing, Richmond, VA.
Background: The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including infections (I) & malignancies (M), to assess for donor transmitted…
2015 American Transplant Congress
Is BK Viral Subtype Distribution of Donor And/Or Recipient Important for Subsequent BK Viral Infection After Living-Donor Transplantation?
A. Schwarz,¹ S. Linnenweber-Held,¹ H. Haller,¹ A. Heim,² C. Schmitt.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Virology, Hannover Medical School, Hannover, Germany.
Background: Source and risk factors for developing BK virus (BKV) infection after renal transplantation are unresolved. By genotyping of urine and blood, we looked for…