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Articles tagged "Infection"

  • 2016 American Transplant Congress

    Human MicroRNA Responses Are Predictive of CMV Reactivation Following Solid Organ Transplant.

    S. Han,1 D. Kumar,1 V. Ferreira,1 S. Husain,1 N. Mueller,2 A. Humar,1 M. Mian,1 P. Ashton.1

    1Multi Organ Transplant Program, University Health Network, Toronto, Canada; 2Swiss Transplant Cohort Study, University Hospital Zurich, Zurich, Switzerland.

    Background: Human microRNA (miRNA) can suppress gene expression through binding to the 3' untranslated region (UTR) of the target mRNA. In silico analysis shows that,…
  • 2016 American Transplant Congress

    Do We Need an Individually Tailored Immunosuppression Strategy for Living Donor Kidney Transplant Recipients with PreTransplant Donor Specific Antibodies? A Retrospective Analysis.

    S. Bhutani,1 A. Ponnusamy,2 Q. Tak,1 S. Shah,1 J. Worthington,1 A. Summers,1 K. Poulton,1 D. Van Dellen,1 M. Morton,1 M. Picton.1

    1Department of Renal & Transplant Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; 2Department of Renal Medicine, Royal Hospital Preston, Preston, United Kingdom.

    Introduction:Pre-Transplant Microbead donor HLA specific antibody(DSA) positive but cell crossmatch negative transplants are considered to be at increased immunological risk. This study aimed to address…
  • 2016 American Transplant Congress

    Adenovirus Infection in Kidney Transplant Recipients: Report of a Case Series.

    C. Simancas-Ruiz, L. Marino-Vazquez, A. Meraz-Muñoz, A. Nuñez-Abreu, R. Rivera-Marfil, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplant and Pathology, National Institute of Medical Sciences and Nutrition SZ, México, DF, Mexico.

    Introduction: In kidney transplant recipients, the incidence of adenovirus infection is 4.1%, usually occur in the first three months after transplantation. Patients may have viral…
  • 2016 American Transplant Congress

    Donor-Derived Toxoplasmosis in Solid Organ Transplant 2008 – 2015: Opportunities for Improvement.

    C. Wolfe,1 A. Wilk,2 S. Tlusty,2 C. Sifri,1 M. Morris,1 A. Mehta,1 D. Kaul.1

    1DTAC, Richmond, VA; 2United Network for Organ Sharing, Richmond, VA.

    Background: Donor-derived Toxoplasmosis (DDT) is uncommon, but outcomes may be poor. Donor risk factors are difficult to recognize, and donor screening is not currently universally…
  • 2016 American Transplant Congress

    Do Powerful Induction Antibodies Increase Post Renal Transplant Infections?

    M. John, I. Dortonne, B. Kim, C. Li, M. Killackey, A. Paramesh, B. Lee, R. Zhang, G. Parker, J. Buell.

    Transplant Institute, Tulane University School of Medicine, New Orleans, LA.

    Purpose: Infection is one of the most common and costly complications of solid organ transplantation. Alemtuzemab (AL) is a powerful antibody that significantly reduced rejection…
  • 2016 American Transplant Congress

    Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8+ T Cell Responses.

    A. Karp, M. Wagener, J. Robertson, M. Ford.

    Emory University, Atlanta.

    The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…
  • 2015 American Transplant Congress

    Epidemiology and Outcomes of Non Tuberculous Mycobacterial (NTM) Infections in Solid Organ Transplant (SOT) Recipients

    I. George, C. Santos, M. Olsen, T. Bailey.

    Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

    Background: NTM are uncommon causes of infection in SOT recipients but may cause significant morbidity and mortality.Methods: A retrospective cohort of all patients who underwent…
  • 2015 American Transplant Congress

    Switching from Tacrolimus to Low-Dose Cyclosporine A Preserves Allograft Function in Presumptive and Definitive Polyomavirus-Associated Nephropathy

    G. Huang, C.-X. Wang, J.-G. Fei, J. Qiu, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.

    Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Switching from tacrolimus(Tac) to low-dose cyclosporine A(CsA) is recommended for preventing BK virus-associated nephropathy(BKVAN) and preserving allograft function in BKVAN patients, but systematic evaluations were…
  • 2015 American Transplant Congress

    Impact of Anti-CMV Prophylactic Therapy on the Development of CMV Quantiferon Sero-Conversion in High-Risk Patients

    A. Palanisamy, D. Taber, N. Pilch, C. Bratton, J. McGillicuddy, P. Baliga, K. Chavin.

    Transplant Surgery, Medical University of South Carolina, Charleston, SC.

    Body: Abdominal organ transplants at high risk for CMV infection (D+/R­) remain a difficult cohort to prevent late CMV infection despite prolonged valganciclovir (VGC) administration.…
  • 2015 American Transplant Congress

    Implementation of Pre-Transplant Infectious Disease Risk Assessment: Sustained Success With Rapid-Cycle Improvement

    L. Danziger-Isakov, S. Blum, D. Dahale, B. Morrow, R. Rengering, D. Schoborg, S. Stark, E. Wells, A. Lorts, U. Kotagal, J. Bucuvalas.

    Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    Pre-transplant infectious disease risk assessment can identify and mitigate potential risk for transplant candidates to improve post-transplant outcomes. We aimed to improve pre-transplant ID risk…
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