Articles tagged "Infection"

2017 American Transplant Congress
TNF[part]-I After Kidney Transplantation.
B. Muth, B. Astor, D. Mandelbrot.
Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, WI
Infliximab, adalimumab and etanercept are monoclonal antibodies which inhibit tumor necrosis factor alpha (TNF[part]-I) and are used in the treatment of inflammatory diseases such as…
2017 American Transplant Congress
Deceased Donors with a History of IV Drug Use and Donor Derived Hepatitis C Virus.
D. Kaul,¹ M. Clark,² M. Michaels,¹ S. Tlusty,² C. Wolfe.¹
¹OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; ²UNOS, Richmond
Introduction:In 2015, the CDC reported a 172% increase in heroin-related deaths from 2010 to 2013. Deceased donors with IV drug use (IVDU) are at increased…
2017 American Transplant Congress
Facing Unintended Challenges of Increased Risk Donor Kidneys in a New Kidney Allocation Era.
A. Rahnemai-Azar,¹ J. Perkins,¹ A. Limaye,² N. Leca,³ C. Blosser,³ C. Johnson,³ S. Morrison,¹ R. Bakthavatsalam,¹ L. Sibulesky.¹
¹Abdominal Organ Transplantation, University of Washington Medical Center, Sattle, WA; ²Transplant Infectious Disease, University of Washington Medical Center, Sattle, WA; ³Transplant Nephrology, University of Washington Medical Center, Seattle, WA
Background: In 2014, the Organ Procurement and Transplantation Network (OPTN) approved a new kidney allocation system (KAS). One of the intended goals of this system…
2017 American Transplant Congress
Eight Years of Low-Dose Valganciclovir; Evaluating the Incidence and Risk Factors of CMV in Kidney Transplant Recipients.
S. El Hajj, M. Kim, J. Azzi, S. Gabardi.
Kidney Transplant, Brigham and Women's Hostpial, Boston, MA
Introduction: Cytomegalovirus (CMV) remains one the most clinically relevant and frequent post-transplant infections. Despite the availability of effective antiviral drugs, CMV continues to be of…
2017 American Transplant Congress
Factors in Association with Sepsis Differ Between Simultaneous Pancreas/Kidney and Single Kidney Transplant Recipients.
T. Schachtner,^1,2,3 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
As immunosuppressive therapy and allograft survival have improved in simultaneous pancreas/kidney transplant recipients (SPKTRs), the increased incidence of infection has become a major hurdle of…
2017 American Transplant Congress
NFAT-Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients – A Randomized Controlled Trial.
A. Webber,¹ V. Tatapudi,² C. Leung,³ F. Vincenti.^1,3
¹Division of Nephrology, UCSF, San Francisco, CA; ²Division of Nephrology, NYUMC, New York, NY; ³Surgery, UCSF, San Francisco, CA
Purpose: To demonstrate that a pharmacodynamics assay using Real Time (RT)-PCR to measure residual expression (RE) of nuclear factor of activated T cell (NFAT)-dependent cytokines…
2017 American Transplant Congress
Transplantation of Organs from Donors with Hepatitis C: The Potential to Substantially Increase Transplant Activity.
P. Trotter,^1,2 M. Robb,² I. Ushiro-Lumb,² J. Powell,³ C. Watson,¹ J. Bradley,¹ J. Neuberger.^2,4
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom; ³Hepatic-Pancreatico-Biliary Surgical Services and Edinburgh Transplant Unit, Royal Infirmary Edinburgh, Edinburgh, United Kingdom; ⁴The Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction. Organs from hepatitis C virus positive (HCV+ve) donors are commonly declined for transplantation because of the risk of disease transmission, but new direct acting…
2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…
2017 American Transplant Congress
Incidence of Cytomegalovirus Infection Among Liver Transplant Recipients Maintained on a Cyclosporine vs. Tacrolimus-Based Immunosuppression Regimen.
C. Burrelli, M. Bradley, S. Pouch, E. Elkhammas, H. Winters.
The Ohio State University Wexner Medical Center, Columbus, OH
Background: Cytomegalovirus (CMV) is the most common viral pathogen that affects patient outcomes after liver transplant. Potent immunosuppressive agents predispose patients to an increased risk…
2017 American Transplant Congress
Antibiotic Conservatorship in Orthotopic Liver Transplantation.
J. Yee,² D. Clark,² R. Hogen,^1,2 K. Dhanireddy,¹ S. Biswas,² J. Cobb,² K. Matsushima,² D. Grabo,² A. Strumwasser.²
¹Solid Organ Transplantation, Keck Hospital of USC, Los Angeles, CA; ²Trauma, Acute Care Surgery, Surgical Critical Care, LAC+USC Medical Center, Los Angeles, CA
Post-orthotopic liver transplantation (OLT) infections, especially multidrug resistant organisms (MDRO), are implicated in poorer outcomes, fueling efforts to elucidate risk factors for hospital acquired infections.…