Articles tagged "Infection"

2019 American Transplant Congress
Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children
B. I. Shaw¹, L. Stempora¹, C. Chan¹, R. B. Ettenger², P. C. Grimm³, H. Lee¹, E. F. Reed², M. M. Sarwal⁴, B. L. Warshaw⁵, C. Zhao¹, O. M. Martinez³, A. D. Kirk¹, E. T. Chambers¹
¹Pediatrics/Surgery, Duke University, Durham, NC, ²Pediatrics, University of California, Los Angeles, Los Angeles, CA, ³Pediatrics/Surgery, Stanford University, Palo Alto, CA, ⁴Pediatrics/Surgery, University of California, San Francisco, San Francisco, CA, ⁵Pediatrics, Emory University, Atlanta, GA
*Purpose: Depletional induction therapies are known to reduce the rate of acute rejection; yet data from the US Renal Data System have shown that use…
2019 American Transplant Congress
Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients
J. L. Orejas¹, F. M. Marty¹, A. M. McDonnell², M. P. Cheng¹, E. Arbona-Haddad¹, S. P. Hammond¹, S. Koo¹
¹Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, ²Department of Pharmacy, Brigham and Women's Hospital, Boston, MA
*Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
2019 American Transplant Congress
Infective Complications after Renal Transplantation – A Single Centre Experience Comparing Alemtuzumab to Basiliximab Induction
R. Czajka, M. Welberry Smith, M. Gittus, E. Lindley, M. Vernon
Renal Medicine, St James' University Hospital, Leeds, United Kingdom
*Purpose: Our centre predominantly uses alemtuzumab as induction immunosuppression for renal transplantation. We examined infective complications after renal transplantation, comparing different induction, and maintenance, immunosuppression…
2019 American Transplant Congress
Evaluation of Rabbit Antithymocyte Globulin (rATG) Dosing and Incidence of Opportunistic Viral Infections in Kidney Transplant Recipients Using Tacrolimus (TAC), Mycophenolate (MPA) and Steroid Free Maintenance Immunosuppression
L. Von Stein, A. Leino, R. Amer, T. Pesavento, H. Winters
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: There is limited literature evaluating rATG dosing and incidence of infection with TAC/MPA and early steroid withdrawal. This study evaluates rATG dosing and overall…
2019 American Transplant Congress
EBV Viremia and Development of EBV Specific Cytotoxic T-cells in Pediatric Renal Transplant Recipients
H. Pizzo, D. Puliyanda, B. Shin, M. Toyoda, S. Jordan
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: The use of lymphocyte depleting agents (LDA) for induction immunosuppression among renal transplant (tx) recipients raises concern for the increased susceptibility to viral infections,…
2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2019 American Transplant Congress
A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine
A. G. L'Huillier, V. H. Ferreira, Y. Natori, T. Ku, C. Hirzel, M. Ierullo, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
2019 American Transplant Congress
Circulating Exosomes Isolated from Human Lung Transplant Recipients with Respiratory Viral Infections Contain Nucleic Acids Specific to Virus and Can Lead to Activation of Stress Proteins
S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are membrane vesicles released by cells into body fluids. Our laboratory demonstrated the presence of circulating exosomes with lung self-antigens (SAgs), Collagen V…
2019 American Transplant Congress
Preventing Donor Derived Cryptococcal Infections: Should We Screen Potential Organ Donors with a Serum Cryptococcal Antigen? A Cost Analysis
C. Santos¹, E. Ritz¹, Y. Rhee¹, I. George², J. Pulvirenti³, N. Moore¹, E. Hollinger¹, L. Proia¹
¹Rush University Medical Center, Chicago, IL, ²Washington University, St. Louis, MO, ³Mercy Hospital, Rockford, IL
*Purpose: Donor-derived cryptococcosis is a rare but deadly infection. Serum cryptococcal antigen testing is a sensitive, specific and inexpensive modality that can be used to…
2019 American Transplant Congress
The Economic Impact of Surgical Site Infections in Liver Transplantation
Y. Natori¹, D. Kumar², A. Humar², S. Husain², C. Rotstein³
¹Miami Transplant Institute, University of Miami, Miami, FL, ²Transplant Infectious Diseases, University of Toronto, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
*Purpose: Complications arising after liver transplantation result in additional healthcare costs. Previous studies have not evaluated the impact of surgical site infections on healthcare costs…