Articles tagged "Infection"

2019 American Transplant Congress
Murine Cytomegalovirus Infection Down-Regulates Receptor Tyrosine Kinase MerTK on Macrophages to Abrogate Allograft Tolerance
S. Yu, A. Dangi, M. Burnette, X. Luo
Division of Nephrology, Department of Medicine, Duke Transplant Center, Duke University Medical Center, Durham, NC
*Purpose: Cytomegalovirus (CMV) is one of the most common pathogens infecting solid organ transplant recipients. We recently showed that (1) CMV infection impairs the induction…
2019 American Transplant Congress
Identifying the Proverbial “Needle in the Arm” with Natural Language Processing
G. R. Vece, J. Foutz, A. Placona
Department of Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Donors with a history of IVDU are associated with increased disease transmission risk; However, OPTN forms only request broad historical details relating to donor…
2019 American Transplant Congress
Undernutrition is Associated with Impaired T Cell Protective Immunity in Pediatric Kidney Transplantation
E. T. Chambers¹, C. Chan¹, R. Ettenger², P. Grimm³, E. Reed², M. Sarwal⁴, L. Stempora⁵, B. Warshaw⁶, C. Zhao¹, O. Martinez⁷, A. Kirk⁵
¹Pediatrics, Duke University, Durham, NC, ²Pediatrics, UCLA, Los Angeles, CA, ³Pediatrics, Stanford, Palo Alto, CA, ⁴Pediatrics, UCSF, San Francisco, CA, ⁵Surgery, Duke University, Durham, NC, ⁶Pediatrics, Emory University, Atlanta, GA, ⁷Surgery, Stanford, Palo Alto, CA
*Purpose: Undernutrition has been associated with T cell immune cell dysfunction and infectious complications in non-immunosuppressed children. Thus, we aimed to define T cell phenotypes…
2019 American Transplant Congress
More Advanced Heart Failure Prior To Transplant May Influence The Cytomegalovirus Specific T Cell Response In Cytomegalovirus Positive Recipients.
U. López Cardoza, E. García, C. Díez, J. Roca, N. Sabé, N. Manito, I. Tatjer, A. Cequier, O. Bestard, J. González
Bellvitge Universitary Hospital, L' Hospitalet de Llobregat, Spain
*Purpose: Current assessment of risk of Cytomegalovirus (CMV) infection in CMV+ heart transplant (HT) recipients is poor. A diminished CMV-specific T cell response against 2…
2019 American Transplant Congress
Relationship between Comorbilities and Infectious Disease in Kidney Transplant Recipients Receiving Rituximab
A. Molina-Andújar¹, E. Hermida¹, J. Rovira², F. Cofan¹, P. Ventura-Aguiar¹, N. Esforzado¹, V. Torregrosa¹, D. Cucchiari¹, E. de Souza¹, I. Revuelta¹, F. Oppenheimer¹, F. Diekmann¹, G. Piñeiro¹
¹Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain
*Purpose: Rituximab is commonly used in the context of kidney transplantation. Evidence about infectious complications and its relationship with predictive factors is scarce. The aim…
2019 American Transplant Congress
A Nurse-Driven Influenza Vaccine Ordering Protocol Improves Vaccination Rates in Abdominal Organ Transplant Recipients
T. Ho¹, C. D. Sifri², J. D. Lewis³
¹Department of Medicine, Virginia Commonwealth University, Richmond, VA, ²Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, ³Division of Infectious Diseases, Medical University of South Carolina, Charleston, SC
*Purpose: Solid organ transplant (SOT) recipients are at increased risk of influenza infection and severe influenza-related complications. The influenza vaccine is a safe and effective…
2019 American Transplant Congress
Outcomes Of Dosing Weight Selection On Rabbit Anti-thymocyte Globulin Induction Immunosuppression In High-risk, Obese Renal Transplant Recipients
A. C. Cordry¹, K. Trobaugh¹, L. Ramsey², A. L. Castellanos³, H. Fattah³, T. Rendulic¹
¹Pharmacy, University of Kentucky HealthCare, Lexington, KY, ²University of Kentucky College of Pharmacy, Lexington, KY, ³Nephrology, University of Kentucky HealthCare, Lexington, KY
*Purpose: There are limited data regarding the optimal weight-based dosing strategy for rabbit anti-thymocyte globulin (rATG) induction in renal transplantation. At our center, rATG is…
2019 American Transplant Congress
EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition
B. Mbiribindi¹, J. K. Pena¹, O. Hatton², C. Romero Moreno¹, C. O. Esquivel¹, O. M. Martinez¹, S. M. Krams¹
¹Department of Surgery/ Division of Abdominal Transplant, Stanford University - School of Medicine, Stanford, CA, ²Department of Molecular Biology, Colorado College, Colorado Springs, CO
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2019 American Transplant Congress
Hepatitis C Antibody Positive (HCV Ab+)/Nucleic Acid Test Negative (NAT -) Deceased Donor Kidney Transplantation into Hepatitis C Negative (HCV -) Recipients: Is It Safe?
Y. Taehwan, A. Rajab, G. Bumgardner, t. Pesavento, R. Daloul, A. Michaels, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: Kidneys procured from HCV Ab+/NAT - are not routinely used due to concern for HCV transmission into recipients. However, there has been no report…
2019 American Transplant Congress
Ready for Prime Time: Intentional Allocation of Hepatitis C Positive Livers into Hepatitis C Negative Recipients
P. N. Martins¹, B. Movahedi¹, D. Devuni², P. Mahboub¹, A. Bozorgzadeh¹
¹Surgery, Division of Transplantation, University of Massachusets, Worcester, MA, ²Medicine, Division of Hepatology, University of Massachusets, Worcester, MA
*Purpose: The current discrepancy between supply and demand of liver grafts has dramatically increased the waiting time and mortality on the waiting list. The recent…