Articles tagged "Infection"

2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²
¹Emory Transplant Center, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…
2019 American Transplant Congress
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center
J. S. Kerr, N. Law, S. Aslam
Center for Transplantation, University of California, San Diego Health System, La Jolla, CA
*Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…
2019 American Transplant Congress
Vaccine Response as a Predictor of Kidney Transplant Rejection and Serious Infection
A. Ta'eed, K. R. Polkinghorne, W. R. Mulley
Department of Nephrology, Monash Health, Clayton, Australia
*Purpose: Vaccination generates immune memory, including antibodies against harmful pathogens. Transplant immunosuppression prevents similar processes occurring against alloantigens. Transplant recipients have significantly reduced seroresponses to…
2019 American Transplant Congress
Pneumocystis Prophylaxis in Solid Organ Transplant Recipients at Two Large Transplant Centers from 2015-2016: Why Not Trimethoprim-Sulfamethoxazole?
J. M. Lum¹, V. Athans², I. Echenique³, C. E. Koval¹
¹Infectious Diseases, Cleveland Clinic Floundation, Cleveland, OH, ²Infectious Diseases, University of Pennsylvania, Philadelphia, PA, ³Infectious Diseases, Cleveland Clinic Florida, Weston, FL
*Purpose: Trimethoprim-sulfamethoxazole (T/S) is the drug of choice for Pneumocystis jirovecii pneumonia (PJP) prophylaxis (ppx) after solid organ transplant (SOT). Perceived side effects may lead…
2019 American Transplant Congress
Higher Post-Transplant CXCL13 Correlates with the Occurrence of Infection within 1 Year after Kidney Transplantation
Y. Li¹, Y. Li¹, L. Yan¹, L. Wang¹, Y. Shi², J. Tang¹
¹Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Chengdu, China, ²Department of Nephrology, West China Hospital, Chengdu, China
*Purpose: Chemokine is a subtype of cytokines that involved in the process of inflammation and immune responses, and play an important role in both kidney…
2019 American Transplant Congress
Donor-Derived Carbapenem-Resistant Klebsiella Pneumoniae Infection after Renal Transplantation
B. Liu, M. Wang, F. Zeng, S. Chang, N. Gong, G. Chen, Z. Chen
Institute of Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
*Purpose: We summarized the experience of diagnosis and treatment of donor-derived carbapene-resistant klebsiella pneumoniae (CRKP) infection after renal transplantation.*Methods: From January 2015 to June 2018,…
2019 American Transplant Congress
Impact of Enteric Vancomycin Resistant Enterococcus Colonization on Waitlist Outcomes among Liver Transplant Candidates
E. Aldag, R. Pedersen, V. Gunabushanam, A. Sahajpal, T. J. Dilworth
Aurora St Luke's Medical Center, Milwaukee, WI
*Purpose: To determine the impact of Vancomycin Resistant Enterococcus (VRE) colonization on 90-day Liver Transplant (LT) waitlist outcomes.*Methods: Single center, retrospective observational study of LT…
2019 American Transplant Congress
Routine Molecular Clostridioides difficile Screening and Overtreatment in Solid Organ Transplant Recipients
M. E. Newman¹, C. Oehler¹, M. Enriquez¹, E. Landon¹, C. T. Nguyen², N. N. Pettit², J. P. Ridgway¹, J. Pisano¹
¹Section of Infectious Disease, University of Chicago Medicine, Chicago, IL, ²Department of Pharmacy, University of Chicago Medicine, Chicago, IL
*Purpose: The objective of this analysis is to determine how frequently positive Clostridioides difficile (CD) screening tests, potentially identifying up to 20% of inpatients with…
2019 American Transplant Congress
Risk Factors for 1-5 Year Major Infection Events (MIE) after Kidney Transplant (KTx) Including First-Year Immunosuppression (IS) Data: An Analysis of the Choosing Immune Suppression in Renal Transplantation by Efficacy and Morbidity (CISTEM) Study
V. Dharnidharka¹, D. Axelrod², Z. Zhang³, M. Schnitzler³, K. Lentine³, B. Kasiske⁴
¹Washington Univ, St. Louis, MO, ²Univ of Iowa, Iowa City, IA, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN
*Purpose: From our CISTEM study of linked national registries, we reported that older recipient age, female sex, diabetic kidney failure, non-standard-criteria organs, and mTORi-based IS…
2019 American Transplant Congress
Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients
M. Abdulnoor¹, S. Isabel¹, T. Paton¹, N. Khodai-Booran¹, T. Schechter¹, P. Birk², T. Blydt-Hansen³, B. Foster⁴, S. Mital¹, V. Phan⁵, S. Urschel⁶, G. Casallo¹, T. Papaz¹, L. Hamiwka⁷, S. Min¹, U. Allen¹
¹University of Toronto, Toronto, ON, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵University of Montreal, Montreal, QC, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷University of Calgary, Calgary, AB, Canada
*Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…