Articles tagged "Infection"

2022 American Transplant Congress
Sustained Alloantigen Exposure Reinforces Transplantation Tolerance
J. B. Allocco¹, C. McIntosh¹, P. Wang¹, Y. Wang¹, M. Miller¹, H. Sattar², D. Yin³, Z. J. Zhang⁴, A. Chong³, M. Alegre¹
¹Department of Medicine, University of Chicago, Chicago, IL, ²Department of Pathology, University of Chicago, Chicago, IL, ³Department of Surgery, University of Chicago, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: While advances have been made in therapies that achieve tolerance in mouse transplant models, successful tolerance is still vulnerable to inflammatory challenges that can…
2022 American Transplant Congress
Posoleucel as Preemptive Therapy for BKV Infection in Kidney Transplant Recipients: Safety and Tolerability in a Phase 2 Trial
R. K. Wali¹, M. Singh², D. Wojciechowski³, M. J. Ansari⁴, B. Lonze⁵, V. Nair⁶, A. Sharma⁷, S. Knechtle⁸, F. Cardarelli⁹, A. Chandraker¹⁰
¹Inova Transplant Center, Falls Church, VA, ²U. of Pittsburg Medical Center, Harrisburg, PA, ³UT Southwestern Medical Center, Dallas, TX, ⁴Northwestern U. Feinberg School of Medicine, Chicago, IL, ⁵NYU Langone Transplant Institute, New York, NY, ⁶Northwell Health, Manhasset, NY, ⁷U. of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Duke U. School of Medicine, Durham, NC, ⁹AlloVir, Cambridge, MA, ¹⁰Brigham & Women's Hospital, Boston, MA
*Purpose: Kidney transplant (KT) recipients with BK viremia are at risk for BK virus (BKV) nephropathy and graft loss. There are no approved therapies for…
2022 American Transplant Congress
Burden of Leukopenia/Neutropenia Among Adult Kidney Transplant Recipients: A Systematic Literature Review of Observational Studies
A. Raval¹, K. Kistler², Y. Tang¹, F. Vincenti³
¹Merck & Co., Inc., Kenilworth, NJ, ²Xcenda, Inc, Carrollton, TX, ³University of California, San Francisco, San Francisco, CA
*Purpose: Leukopenia/neutropenia (L/N) may affect key treatment decisions which could result in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of…
2022 American Transplant Congress
Optimizing Kidney Transplant Immunosuppression Using a Phenotypic Personalized Dosing Model
J. F. Bruner¹, N. Padmanabhan², C. Ho², A. Zarrinpar¹
¹Surgery, University of Florida, Gainesville, FL, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA
*Purpose: Immunosuppression is essential for preventing rejection and promoting long-term graft survival following solid organ transplantation; it also places patients at risk for infection and…
2022 American Transplant Congress
Frequency of Cervical Cancer Screening in Solid Organ Transplant Recipients
C. Papastamelos¹, K. Dokus², M. Laryea³
¹Internal Medicine, University of Rochester Medical Center, Rochester, NY, ²Transplant Division, University of Rochester Medical Center, Rochester, NY, ³Gastroenterology, University of Rochester Medical Center, Rochester, NY
*Purpose: Human papillomavirus-related anogenital malignancies disproportionately affect solid organ transplant recipients (SOTR) compared to the general population. Proposed cervical Pap testing intervals for SOTR differ…
2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
2022 American Transplant Congress
Incidence of Urinary Tract Infection or Asymptomatic Bacteriuria in Kidney Transplant Recipients with Sulfamethoxazole-Trimethoprim vs. Pentamidine for Pneumocystis Jiroveci Pneumonia Prophylaxis
L. Selznick, H. Sweiss, C. Long, S. Bhayana, R. Hall
University Health, San Antonio, TX
*Purpose: To compare the incidence of urinary tract infection (UTI) or asymptomatic bacteriuria (ASB) post-kidney transplant (KT) with multiple Pneumocystis jiroveci pneumonia (PJP) prophylaxis regimens*Methods:…
2022 American Transplant Congress
Organ Transplant Outcomes from Donors with Positive SARS-CoV-2 PCRs in New York: A Case Series
A. L. Friedman¹, M. Pereira², M. Rana³, J. Akpede⁴, A. Dhand⁵
¹LiveOnNY, New York, NY, ²New York Presbyterian Hospital, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴LiveOnNY, Long Island City, NY, ⁵Westchester Medical Center, Chappaqua, NY
*Purpose: Rapid evolution of the SARS-CoV-2 pandemic over the past 24 months has demanded agility in managing selection criteria for deceased organ donors, with the…
2022 American Transplant Congress
Comparison of Perioperative Antibiotic Prophylaxis Regimens on Surgical Site Infections in Pancreas Transplant Recipients
Z. A. Yetmar¹, M. McCord², B. Lahr³, A. Lemke², P. G. Dean⁴, Y. C. Kudva⁵, M. T. Seville⁶, W. Bosch⁷, S. A. Bernard², E. Beam¹
¹Division of Infectious Diseases, Mayo Clinic, Rochester, MN, ²Department of Pharmacy, Mayo Clinic, Rochester, MN, ³Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, ⁴Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, ⁵Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, ⁶Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, ⁷Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL
*Purpose: Pancreas transplant recipients are at high risk of surgical site infection (SSI), with rates ranging from 9-45%. Several risk factors for SSI have been…
2022 American Transplant Congress
A Multi-Center Study Assessing the Association of Frailty with Infection in Kidney Transplant Recipients
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale University School of Medicine, New Haven, CT, ²University of CO, Aurora, CO, ³Stanford, Palo Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a multi-dimensional characterization of decreased reserve and diminished response to stressors in older adults. Frailty at the time of transplant has been…