Articles tagged "Infection"

2020 American Transplant Congress
T Cell Dysfunction as Measured by Impaired Antigen Response is Associated with Infection and Frailty in Kidney Transplant Recipients
J. Schaenman, M. Rossetti, V. Groysberg, G. Sunga, E. Liang, S. Bunnapradist, E. Reed
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Kidney transplant recipients are at risk for infection, especially the growing numbers of older patients. Our previous studies demonstrated that senescent and exhausted T…
2020 American Transplant Congress
The Impact of Purposeful Reductions in Immunosuppression on Clinical Outcomes in Kidney Transplantation
K. Foster, H. Perkins, N. Patel, C. Perez, N. Pilch, H. Meadows, F. Bartlett, V. Rao, M. Casey, M. Posadas Salas, K. Soliman, J. McGillicuddy, D. Taber
MUSC Health, Charleston, SC
*Purpose: Reductions to immunosuppressive therapy (IS) are often made due to infection or other IS intolerances, but little is known of impact of these reductions…
2020 American Transplant Congress
Low-Dose Rabbit Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients at High Immunologic Risk is Safe and May Prevent Excess Rejection
E. Sartain¹, B. Nettles¹, B. Crowther¹, P. Klem¹, K. Schwarz¹, S. Davis²
¹University of Colorado Hospital, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
*Purpose: Patients aged ≥65 years are a growing segment of kidney transplant recipients (KTRs). Consensus on induction immunosuppression in this population is unclear given higher…
2020 American Transplant Congress
Evaluation of a Surveillance after Prophylaxis Strategy for Cytomegalovirus Prevention in Liver Transplant Recipients
N. Parrish¹, A. Webb², T. Kaiser¹, S. Shah¹, N. Anwar¹, K. Luckett¹
¹University of Cincinnati Med Ctr, Cincinnati, OH, ²Tampa General Hospital, Tampa, FL
*Purpose: Despite prophylaxis and preemptive strategies, CMV infection remains a common complication post liver transplant (LT). CMV surveillance after prophylaxis may improve outcomes, but supporting…
2020 American Transplant Congress
Endoscopic Injection Therapy for Vesicoureteral Reflux after Kidney Transplantation
H. Higuchi, H. Sasaki, H. Harada, T. Tanabe
Urology and Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Sapporo, Japan
*Purpose: Vesicoureteral reflux (VUR) in a kidney graft is a complication of post kidney transplantation (KT) causing recurrent upper urinary tract infection and consequent kidney…
2020 American Transplant Congress
The Level of Plasm Donor-Derived Cell-Free DNA in Kidney Transplant Patients with Severe Pneumonia
L. Liu¹, H. Liu², F. Liu², L. Shu², L. Peng¹
¹Xiangyang Hospital No. 2 of Central South University, Changsha, China, ²AlloDx, Shanghai; Suzhou, China
*Purpose: Pulmonary infection is one of the common complications after kidney transplantation. Donor-derived cell-free DNA (ddcfDNA) is a new biomarker to diagnose allograft injury. Currently,…
2020 American Transplant Congress
Safety and Efficacy of Low Dose Rabbit Antithymocyte Globulin in Pediatric Renal Transplant Recipients
V. K. Sigurjonsdottir¹, L. Maestretti¹, A. McGrath¹, A. Gallo², W. Concepcion², P. Grimm¹, A. Chaudhuri¹
¹Pediatric Nephrology, Stanford University, Stanford, CA, ²Surgery - Multi-Organ Transplantation, Stanford University, Stanford, CA
*Purpose: Currently there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.The safety and effectiveness of reduced…
2020 American Transplant Congress
The Forgiven Disease: Outcomes of Lung Transplantation in Two HIV-Infected Patients
S. Biswas Roy¹, M. T. Olson², M. A. Smith¹, R. M. Bremner¹, R. Walia¹, A. Arjuna¹
¹Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, ²University of Arizona College of Medicine - Phoenix, Phoenix, AZ
*Purpose: Human immunodeficiency virus (HIV) seropositivity is generally considered a contraindication to lung transplantation (LTx). HIV-infected adults are at higher risk of developing chronic lung…
2020 American Transplant Congress
Successful Use of Tedizolid for the Treatment of Nocardiosis in Transplant Recipients
R. Odrobina¹, B. Tritle², C. A.Gomez¹
¹Division of Infectious Diseases, University of Utah, Salt Lake City, UT, ²Department of Pharmacy, University of Utah, Salt Lake City, UT
*Purpose: Nocardiosis is an opportunistic infection occasionally seen after solid organ (SOT) and hematopoietic stem-cell transplantation. Treatment is challenging due to the limited number of…
2020 American Transplant Congress
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
R. L. Crepeau¹, H. Li¹, H. S. Koehler², M. L. Ford¹, P. D. Winterberg³
¹Surgery, Emory University, Atlanta, GA, ²Microbiology and Immunology, Emory University, Atlanta, GA, ³Pediatrics, Emory University, Atlanta, GA
*Purpose: We have previously reported that patients with chronic kidney disease (CKD) accumulate memory T cells bearing markers of sustained antigen stimulation and enhanced pro-inflammatory…