Articles tagged "Infection"

2021 American Transplant Congress
Impact of Positive Donor Cultures on Postoperative Lung Transplantation Infectious Outcomes
A. Curtis, C. Pham, B. P. Pierce
Houston Methodist Hospital, Houston, TX
*Purpose: Transmission risk of microbes present in donor lungs at time of donation to lung transplant recipients (LTR) is unclear. Infection is the second highest…
2021 American Transplant Congress
High Levels of Sars-cov-2 Detected in Immunosuppressed Covid-19 Patient Environments Weeks Following Initial Positive Test
C. E. Kuschner¹, Z. Brune², L. B. Becker¹, L. Teperman¹
¹North Shore University Hospital, Manhasset, NY, ²Feinstein Institutes for Medical Research, Manhasset, NY
*Purpose: COVID-19 is a novel viral illness associated with significantly worse mortality, prolonged disease course, and extended periods of viral shedding in transplant patients on…
2021 American Transplant Congress
T-cell-Mediated Immunity to Sars-cov-2 Defines Covid-19 Risk and Severity in Transplanted and Non-Transplanted Individuals and Associates with Myeloid-Derived Suppressor Cells
C. Ashokkumar¹, V. Rohan², A. H. Kroemer³, S. Rao⁴, G. Mazariegos⁵, B. W. Higgs⁵, S. Nadig², M. Ningappa⁵, T. Fishbein³, S. Subramaniam⁶, R. Sindhi⁷
¹Plexision, Pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶University of California, San Diego, CA, ⁷University of Pittsburgh, pittsburgh, PA
*Purpose: We assessed whether COVID-19-risk is enhanced by chronic immunosuppression, and is associated with suppressor cells.*Methods: We tested 66 COVID-19 patients, including 26 with solid…
2021 American Transplant Congress
Covid-19 in Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C)
G. Agarwal¹, A. Vinson², R. Dai³, E. French⁴, S. Lee⁵, A. Olex⁴, A. Anzalone⁶, V. Madhira⁷, R. B. Mannon⁸
¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Medicine/Nephrology, Nova Scotia Health Authority, Halifax, NS, Canada, ³Biostatistics, University of Nebraska Medical Center, Omaha, NE, ⁴Wright Center for Clinical and Translational Research, VIrginia Commonwealth University, Richmond, VA, ⁵Medicine/Infectious Disease, University of Saskatchewan, Saskatoon, SK, Canada, ⁶Neurology, University of Nebraska Medical Center, Omaha, NE, ⁷Palia Software, Not sure, OR, ⁸Medicine/Nephrology, University of Nebraska Medical Center, Omaha, NE
*Purpose: SARS-CoV-2 infection has resulted in significant mortality in solid organ transplant (SOT) recipients based on reports from single centers or voluntary registries. The N3C…
2021 American Transplant Congress
Should We Worry About Covid-19 Infection in Pediatric SOT?
U. Ekong¹, S. Paul¹, S. Royal², J. Chahine³, N. Yazigi¹, S. Kaufman¹, K. Khan¹, C. Matsumoto¹, A. Kroemer¹, T. Fishbein¹
¹Surgery, Medstar Georgetown Transplant Institute, Washington, DC, ²Pediatrics, Medstar Georgetown University Hospital, Washington, DC, ³Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC
*Purpose: We describe the clinical presentation & immune response to COVID-19 infection in pediatric SOT.*Methods: Medical records of COVID-19 PCR+ or seropositive patients were reviewed…
2021 American Transplant Congress
Observational Study of the Clinical Characteristics and Short-term Outcomes of Kidney Transplant Recipients Diagnosed with Coronavirus-19 Infection (sars-cov2) Requiring Hospitalization in New Orleans
S. Giusti¹, S. Chazin², P. Vaitla³, K. Atiemo⁴, M. Atari¹, A. Paramesh⁴, H. Jeon⁴, A. Vijay⁴, A. Torres⁵, M. Killackey⁴, R. Thimmisetty⁶, J. Garces⁶
¹Tulane University Section of Nephrology & Hypertension, New Orleans, LA, ²Tulane University School of Medicine, New Orleans, LA, ³University of Mississippi Medical Center, Jackson, MS, ⁴Tulane Transplant Institute, New Orleans, LA, ⁵Ochsner Medical Center, New Orleans, LA, ⁶Ochsner Multi-Organ Transplant Institute, New Orleans, LA
*Purpose: Kidney transplant recipients are at increased risk of severe disease and death caused by Coronavirus-19 infection. The role of immunosuppressive medications in the clinical…
2021 American Transplant Congress
Clinical Outcomes of Culture-Positive Pneumonia in Solid Organ Transplant Recipients
L. Rice¹, A. C. Kalil², D. Hixson², M. Leick³
¹Monument Health, Rapid City, SD, ²University of Nebraska Medical Center, Omaha, NE, ³Nebraska Medicine, Omaha, NE
*Purpose: The purpose of this study is to determine the differences in clinical outcomes of culture-positive pneumonia in solid organ transplant (SOT) recipients compared to…
2021 American Transplant Congress
Delay in Pediatric Kidney Transplantation Due to Infection: A Single Center Study
T. A. Heald-Sargent¹, S. Manz², P. Verghese³
¹Pediatric Infectious Diseases, Lurie Children's Hospital/Northwestern University, Chicago, IL, ²Central Michigan University, Mt Pleasant, MI, ³Pediatric Kidney Diseases, Lurie Children's Hospital/Northwestern University, Chicago, IL
*Purpose: The infectious risks of immunosuppression following pediatric kidney transplant are well described but little is known about the impact of infections on patients with…
2021 American Transplant Congress
The Impact of High Kdpi on 1-year Post-transplant Graft Function and Survival in a Brazilian Cohort
H. Tedesco Silva Junior, R. Demarchi Foresto, M. Hazin, B. Cassão, A. Aquino, J. Taddeo, C. Rosso Felipe, L. Requião Moura, J. Medina
Núcleo de Ensino e Pesquisa, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the impact of High Kidney Donor Profile Index (KDPI) on 1-year post-transplant renal function and graft survival.*Methods: This retrospective cohort analyzed 3,059…
2021 American Transplant Congress
Mortality from Fulminant Myocarditis in Multi-organ Transplant Recipient with Covid-19
K. Mahendraraj, I. Kim, T. Todo, T. Brennan, N. Nissen, K. Kosari, G. Voidonikolas, D. Ramzy
Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Novel coronavirus infection has been rarely described in multi-organ transplantation. This case highlights the poor prognosis associated with cardiac involvement by SARS-Cov-2 in transplantation,…