Session Name: All Infections (Excluding Kidney & Viral Hepatitis)
Session Date & Time: None. Available on demand.
*Purpose: The Centers for Disease Control and Prevention identified solid organ transplant (SOT) recipients as persons at high risk to develop severe illness secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We reviewed the clinical characteristics and outcomes of SOT recipients who had SARS-CoV-2 at our center.
*Methods: This was a retrospective review of SOT recipients diagnosed with SARS-CoV-2 between March 1st 2020 and September 31st 2020 in the Medical University of South Carolina (MUSC) Health Care system. Subjects were included if they had undergone SOT at any time prior to a positive SARS-CoV-2 PCR. Descriptive statistics were used to analyze demographic and clinical characteristics. Primary outcomes included need for hospitalization, complications, and estimated all-cause mortality.
*Results: 51 SOT recipients were diagnosed with SARS-CoV-2. Five patients were excluded as they initially tested positive and were admitted to another facility. 46 SOT recipients were analyzed, of which, 31 (67%) were hospitalized. Of those hospitalized, 45% were males, 68% were black and 71% were kidney transplant recipients. Median length of stay was three days (range 0.6-108.6). 10 (32%) patients required supplemental oxygen and 6 (19%) received care in the intensive care unit. Complications, including bacterial infections (16%), fungal infections (3%), CMV reactivation (6%), and rejection (3%) were rare. One patient (2%) died during the study time period.
*Conclusions: The majority of SOT recipients with SARS-CoV-2 in our cohort required admission, however they experienced few complications and a low mortality, despite their high-risk status.
To cite this abstract in AMA style:Adekunle R, Jandhyala D, Lewis J. Clinical Outcomes of Solid Organ Transplant Recipients with Severe Acute Respiratory Syndrome Coronavirus 2 [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-outcomes-of-solid-organ-transplant-recipients-with-severe-acute-respiratory-syndrome-coronavirus-2/. Accessed June 12, 2021.
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