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Articles tagged "Induction therapy"

  • 2020 American Transplant Congress

    Thymoglobulin (ATG) Induction vs. Campath vs. Simulect in DCD Kidneys in UK; Induction Regimes Play a Role after All

    A. Asderakis1, T. Sabbah1, J. Watkins2, L. Szabó1, D. Elker1, A. M. Ilham1, E. Ablorsu1, M. Stephens1, U. Khalid1, R. Chavez1

    1Cardiff Transplant Unit,, University Hospital of Wales, Cardiff, United Kingdom, 2Infection and Immunity, Cardiff University, Cardiff, United Kingdom

    *Purpose: Controlled DCD kidneys have increased dramatically in UK. They suffer from a higher rate of DGF and, often in UK, come from older donors…
  • 2020 American Transplant Congress

    Safety Outcomes in Lower-Weight vs Higher-Weight Recipients of Fixed Dose Alemtuzumab for Kidney Transplant Induction

    A. Freeman, S. Anders, B. Wise, M. Janusek, L. Hutchinson, U. Kaszubski, D. Marroquin, D. Martin, H. Bohorquez

    Ochsner Medical Center, New Orleans, LA

    *Purpose: Alemtuzumab is a lymphocyte-depleting monoclonal antibody used for renal transplant induction, and is associated with significant leukopenia, increased infections and malignancy. Multiple dosing strategies…
  • 2020 American Transplant Congress

    Ten Year Results of a Single Center Study of Rabbit Anti-Thymocyte Globulin Compared to Alemtuzumab Induction in Simultaneous Pancreas-Kidney Transplantation

    V. Gurram, K. Gurung, G. Orlando, A. Farney, J. Rogers, C. Jay, W. Doares, S. Kaczmorski, A. Reeves-Daniel, A. Mena-Gutierrez, M. Gautreaux, R. Stratta

    Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC

    *Purpose: The study purpose was to analyze 10-year outcomes of depleting antibody induction agents in simultaneous pancreas-kidney transplant (SPKT) at a single center*Methods: From 2/02…
  • 2020 American Transplant Congress

    Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture

    M. Colladant1, J. Lion2, P. Saas3, S. Perruche3, D. Ducloux1, N. Mooney2, J. Bamoulid1

    1Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, 2Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, 3INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France

    *Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
  • 2020 American Transplant Congress

    Evaluation of Infectious and Malignant Complications in Elderly Renal Transplant Recipients Receiving Alemtuzumab Compared to Basiliximab

    K. Lang1, J. Shulte1, K. Cunningham1, C. D'Agostino1, M. Kapugi1, C. Kane1, A. Novak1, J. Leventhal2

    1Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Division of Transplant Surgery, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx), especially for elderly recipients. For this population, there is limited data…
  • 2020 American Transplant Congress

    Comparative Study between ATG and Grafalon as Induction Agent in Renal Transplant Recipient

    L. K. Das, P. Paudyal, S. Shrestha, B. Shahi, A. Pandey, R. Verma, P. Chandra Shrestha

    Kidney and Liver Transplant, Shahid Dharmabhakta National Transplant Center, Kathmandu, Nepal

    *Purpose: Renal transplantation (Rtx) remains the most effective treatment for of end-stage renal disease (ESRD). The development of induction therapy has significantly reduced the incidence…
  • 2020 American Transplant Congress

    Donor-Derived Cell-Free DNA Levels During Early Rejection after Kidney Transplant May Be Impacted by Type of Induction Agent Received

    M. Gillespie, K. Lim, A. Vo, E. Huang, N. Ammerman, A. Peng, R. Najjar, S. Sethi, S. Jordan

    Cedars-Sinai, Los Angeles, CA

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an injury biomarker that detects rejection in kidney transplant recipients (KTR). It is reported as % cfDNA from the…
  • 2020 American Transplant Congress

    Incident Malignancies among Post Kidney-Transplant Patients by Type of Induction Immunosuppression and by Age

    L. Wang, J. Motter, S. Bae, D. Segev, M. McAdams DeMarco

    Johns Hopkins University, Baltimore, MD

    *Purpose: Adult kidney-transplant (KT) recipients have a differential risk of malignancies based on their induction immunosuppression (IS) therapy. However, older recipients are more likely to…
  • 2020 American Transplant Congress

    Efficacy and Safety of Single-Dose Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction among Pediatric Kidney Transplant Recipients

    L. Porini Custodio, S. Stopa Martins, L. Almeida Viana, M. Pontello Cristelli, M. Rika Nakamura, H. Tedesco-Silva, J. Medina-Pestana

    Hospital do Rim, Sao Paulo, Brazil

    *Purpose: Induction therapy is a standard component of kidney transplant immunosuppression protocols. However, in the pediatric population, there are still uncertainties about the ideal induction…
  • 2020 American Transplant Congress

    Safety and Efficacy of Low Dose Rabbit Antithymocyte Globulin in Pediatric Renal Transplant Recipients

    V. K. Sigurjonsdottir1, L. Maestretti1, A. McGrath1, A. Gallo2, W. Concepcion2, P. Grimm1, A. Chaudhuri1

    1Pediatric Nephrology, Stanford University, Stanford, CA, 2Surgery - Multi-Organ Transplantation, Stanford University, Stanford, CA

    *Purpose: Currently there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.The safety and effectiveness of reduced…
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