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Articles tagged "Induction therapy"

  • 2015 American Transplant Congress

    Evaluation of a Three-Dose Basiliximab Induction Immunosuppression Regimen in Adult Heart Transplant Recipients

    L. Donohue, W. Ally, S. Dunn, J. Kennedy, J. Bergin.

    University of Virginia Health System, Charlottesville, VA.

    Background: Calcineurin inhibitors (CNI) are essential agents in most orthotopic heart transplantation (OHT) anti-rejection regimens. However, nephrotoxicity limits their use in the immediate post-OHT period,…
  • 2015 American Transplant Congress

    Blood Gene Expression Profiling in a Randomized Controlled Trial of rATG Vs. IL2RA Induction Reveals the Differences in Immune Impact and Mechanisms

    K. Chavin,1 D. Taber,1 S. Kurian,2 T. Gelbart,2 N. Pilch,1 S. Nadig,1 J. McGillicuddy,1 T. Srinivas,1 C. Bratton,1 P. Baliga,1 D. Salomon.2

    1MUSC, Charleston, SC; 2Scripps Research Institute, La Jolla, CA.

    We performed global gene expression profiling using microarrays on samples from a prospective, RCT designed to study the safety & efficacy of induction with antithymocyte…
  • 2015 American Transplant Congress

    Single Center Experience With the Use of an Abbreviated Anti-Thymocyte Globulin and Basiliximab Combination Protocol in Renal Transplantation

    V. Whittaker,1 D. Halleran,1 S. Narsipar,1 J. Melancon.2

    1Surgery, State University New York Upstate Medical University, Syracuse, NY; 2Surgery, George Washington University, Washington, DC.

    Purpose: To report one year outcomes from single center experience with a novel induction regimen using anti-thymocyte globulin ( ATG)(rabbit)rATG (3 mg/kg) in divided doses…
  • 2015 American Transplant Congress

    Alemtuzumab in Elderly Renal Transplant Recipients Is Not Associated With a Poor Outcome

    D.-A. Moutzouris, L. Koizia, M. Willicombe, R. Corbett, N. Duncan, J. Galliford, A. McLean, D. Taube.

    Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    The use and choice of induction immunosuppression in elderly kidney recipients remains unresolved. Alemtuzumab has been associated with a higher risk of death and graft…
  • 2015 American Transplant Congress

    Renal Function Following Basiliximab Induction in Liver Transplant Recipients

    J. Hagopian, T. Horwedel, L. Bowman, K. Collins, M. Doyle.

    Washington University School of Medicine, St. Louis.

    Purpose: Reports of the use of antibody induction to delay the start of calcineurin inhibitor therapy postoperatively in patients with renal insufficiency at the time…
  • 2015 American Transplant Congress

    Kidney Patients at High Immunological Risk Can Be Safely Transplanted With a Novel Induction Regimen Using Anti-Thymocyte Globulin (Rabbit) (rATG) Plus Basiliximab

    D. Halleran,1 J. Melancon,2 V. Whittaker.1

    1Surgery, State University New York Upstate Medical University, Syracuse, NY; 2Surgery, George Washington University, Washington, DC.

    Purpose: We report the outcomes from our single center experience with the novel induction regimen using rATG (3 mg/kg) in divided doses given on operative…
  • 2015 American Transplant Congress

    Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells

    K. Samy, H. Xu, A. Kirk.

    Surgery, Duke University Medical Center, Durham, NC.

    Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
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