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American Transplant Congress abstracts

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Articles tagged "Induction therapy"

  • 2015 American Transplant Congress

    Immune-Mediated Injury in Kidney Transplant Recipients Treated With Alemtuzumab Induction and a Steroid Avoidance Protocol

    R. Sapir-Pichhadze, T. Mahbub, C. Saw, D. Baran.

    McGill University Health Centre, Montreal, Canada.

    Study purpose: We evaluated short-term clinical and immunological outcomes of kidney transplant recipients who received alemtuzumab induction and a steroid-avoidance protocol.Methods: This is a retrospective…
  • 2015 American Transplant Congress

    The Impact of Alemtuzumab and Basiliximab Induction On Patient and Graft Survival in Single Lung Transplant Recipients

    Y. Furuya,1 S. Jayarajan,2 S. Taghavi,2 V. Ambur,2 F. Cordova,3 N. Patel,3 Y. Toyoda.4

    1Internal Medicine, Temple University Hospital, Philadelphia, PA; 2Surgery, Temple University Hospital, Philadelphia, PA; 3Pulmonary & Critical Care, Temple University Hospital, Philadelphia, PA; 4Cardiothoracic Surgery, Temple University Hospital, Philadelphia, PA.

    PurposeTo evaluate the impact of alemtuzumab, basiliximab and no induction therapy on patient survival and chronic rejection.Methods3242 adult single lung transplantation from 2006 to 2013…
  • 2015 American Transplant Congress

    Optimal Induction Therapy (IT) in Pancreas After Kidney Transplantation (PAK) According to Type of Kidney (kd) Donor and Patient Risk – A Registry Analysis

    R. Gruessner,1 A. Gruessner.2

    1University of Arizona, Tucson, AZ; 2University of Arizona, Tucson, AZ.

    Purpose: Best IT in PAK recipients (rec) according to type of kd donor (LD vs. DD) and rec risk has not been determined.Methods: Using the…
  • 2015 American Transplant Congress

    Induction With an Interleukin-2 Receptor Antagonist in Sensitized Adult Kidney Transplant Recipients Is Highly Effective and Safe

    J. Casale, J. Fleming, D. Taber, C. Staino, K. Boyle, K. Covert, N. Pilch, H. Meadows, C. Mardis, K. Chavin, C. Bratton, J. McGillicuddy, P. Baliga.

    MUSC, Charleston, SC.

    Background: The effectiveness and safety of induction with basiliximab (IL2RA) in sensitized kidney transplant recipients is not clearly established. The aim of this study was…
  • 2015 American Transplant Congress

    The Association of Basiliximab and Antithymocyte Globulin Induction With Delayed Graft Function

    D. Felix,1 B. Astor,2 D. Hager,1 A. Djamali.2

    1Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI; 2Department of Medicine - Division of Nephrology, University of Wisconsin Hospital and Clinics, Madison, WI.

    The impact of selection of induction immunosuppression agent on incidence of delayed graft function (DGF) remains unclear. A total of 1,980 deceased donor kidney transplant…
  • 2015 American Transplant Congress

    10 Year Experience Using a Steroid Free Three Drug Maintenance Immunosuppression Regimen for Pancreas Transplant Alone: Comparison of Induction With Rabbit Antithymocyte Globulin +/- Rituximab

    J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

    Graft survival following pancreas transplant alone (PTA) is inferior to other pancreas transplants. Steroid elimination is appealing, but a two drug maintenance strategy may be…
  • 2015 American Transplant Congress

    Molecular Features of Kidney Transplant Biopsies Without Allograft Injury in Relation With Type of Induction Therapy

    M. Ajaimy,1 P. O Broin,2 M. Lubetzky,1 Y. Bao,1 A. Golden,2 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.

    Objective: Molecular evidence of allograft injury might precede histopathological findings of allograft injury. We aimed to investigate if the type of induction therapy effect intragraft…
  • 2015 American Transplant Congress

    Campath Induction With Triple Maintenance Therapy in African American Kidney Transplant Recipients: Less Infections But Worse Graft Survival

    M. Gillespie, F. Rasetto, B. Masters, T. Sparkes, B. Ravichandran, M. Moss, A. Haririan.

    University of Maryland Medical Center, Baltimore, MD.

    Introduction:African American (AA) kidney transplant recipients (KTR) are at a higher risk for worse clinical outcomes vs non-AA. Strategies to improve outcomes in AA KTR…
  • 2015 American Transplant Congress

    Thymoglobulin Versus IL2RA: Three Year Results of a Randomized Controlled Trial

    N. Pilch, H. Meadows, D. Taber, J. Fleming, C. Mardis, S. Nadig, J. McGillicuddy, T. Srinivas, C. Bratton, P. Baliga, K. Chavin.

    Transplant, MUSC, Charleston, SC.

    This is a three year follow-up of a prospective, randomized controlled trial (RCT) to determine the safety and efficacy of induction with rabbit antithymocyte globulin…
  • 2015 American Transplant Congress

    IL-17 Production Influenced by Induction Therapy With ATG

    D. Abendroth,1 M. Marzinzig,1 J. Kaden.2

    1Center of Surgery, University of Ulm, Ulm, Germany; 2Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany.

    Introduction Immune-mediated rejection remains the most important cause of graft failure. Recently, a newly identified CD4+ T cell subset, Th17, distinct from Th1 or Th2,…
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