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Articles tagged "Induction therapy"

  • 2016 American Transplant Congress

    Reduced CMV Infection Using Single Low-Dose of Rabbit Anti-Thymocyte Globulin in Kidney Transplanted Recipients.

    M. Paula, C. Felipe, M. Cristelli, P. Orlandi, L. Viana, G. Basso, P. Carvalho, C. Montenegro, A. Lima, I. Pietrobom, H. Tedesco-Silva, J. Medina-Pestana.

    Hospital do Rim - UNIFESP, Sao Paulo, Brazil.

    BACKGROUND: Cytomegalovirus (CMV) infection is associated with significant morbidity and mortality after solid organ transplantation and the historic incidence of our institution was 77%. Aiming…
  • 2016 American Transplant Congress

    Do Powerful Induction Antibodies Increase Post Renal Transplant Infections?

    M. John, I. Dortonne, B. Kim, C. Li, M. Killackey, A. Paramesh, B. Lee, R. Zhang, G. Parker, J. Buell.

    Transplant Institute, Tulane University School of Medicine, New Orleans, LA.

    Purpose: Infection is one of the most common and costly complications of solid organ transplantation. Alemtuzemab (AL) is a powerful antibody that significantly reduced rejection…
  • 2015 American Transplant Congress

    Tracking T Cell Fate After Antithymocyte Globulin (ATG) Immunotherapy in Infant Heart Transplant (HTx) Patients

    S.-I. Wang,1,2 I. Larsen,1,2 S. Urschel,1,2 R. Chinnock,3 J. Rusch,3 L. West.1,2

    1Univ. of Alberta, Edmonton, Canada; 2Alberta Transplant Institute, Edmonton, Canada; 3Loma Linda Univ., Loma Linda.

    Polyclonal T cell depletion with ATG is a common induction therapy in adult and pediatric transplantation. In adults, T cell recovery post-ATG involves homeostatic proliferation…
  • 2015 American Transplant Congress

    Thymoglobulin Dosing Efficacy: The Role of ALC on Infection and Rejection

    H. Sarumi, C. Borscheid, G. Sieger, B. Fast, S. Hogan, K. Vassar, T. Pruett.

    University of Minnesota, Minneapolis, MN.

    There are varied Thymoglobulin® (Thymo) induction regimens accepted among transplant programs. Our center uses five doses of Thymo at 1.25mg/kg, yielding a total goal of…
  • 2015 American Transplant Congress

    Current Status of US Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Intestine Transplant Registry

    J. Cai,1 A. Qing,2 G. Wu,3 M. Everly,1 P. Terasaki.1

    1Terasaki Foundation Lab, Los Angeles, CA; 2Lincoln High School, Stockton, CA; 3The 4th Military Medical University, Xi-An, China.

    The purpose of this study is to analyze the current status of US intestinal transplantation (IT). As of 9/19/2014, 2441 IT have been performed in…
  • 2015 American Transplant Congress

    Induction Therapy (IT) in Simultaneous Pancreas and Kidney Transplantation (SPK) according to Patient Risk – A Registry Analysis

    R. Gruessner,1 A. Gruessner.2

    1Department of Surgery, University of Arizona, Tucson, AZ; 2College of Public Health, University of Arizona, Tucson, AZ.

    Purpose: Optimal IT in SPK recipients (rec) according to patient risk has not been studied.Methods: Using the International Pancreas Transplant Registry database, we analyzed IT…
  • 2015 American Transplant Congress

    Alemtuzumab Dose Adjusted for Weight Reduces Infection Post-Renal Transplantation

    C.-H. Yoon, M. Willicombe, C. Jogia, R. Charif, J. Galliford, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    Alemtuzumab [AL] has been increasingly used as an induction agent in renal transplantation. It causes potent lymphocyte depletion and as has been shown to reduce…
  • 2015 American Transplant Congress

    Induction Avoidance in 2-Haplotype-Matched White Living Kidney Transplantation

    Z. Brifkani,1 T. Alhamad,1 T. Horwedel,2 R. Delos Santos,1 T. Maw,1 D. Brennan.1

    1Transplant Nephrology, Washington University in St. Louis, St. Louis, MO; 2Barnes Jewish Hospital, St. Louis, MO.

    Background: We hypothesize that 2-haplotype matched white living kidney transplant recipients carry a low immunologic risk for rejection, and therefore do not give induction therapy…
  • 2015 American Transplant Congress

    Pancreas Transplantation Immunosuppression Induction With Rabbit Antithymocyte Globulin +/- Rituximab and Early Steroid Withdrawal: Experience With >500 Recipients

    J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

    T-cell depleting antibody induction, often combined with steroid withdrawal, has become standard practice for pancreas transplantation. In this study, outcomes of >500 pancreas transplants using…
  • 2015 American Transplant Congress

    Immune-Mediated Injury in Kidney Transplant Recipients Treated With Alemtuzumab Induction and a Steroid Avoidance Protocol

    R. Sapir-Pichhadze, T. Mahbub, C. Saw, D. Baran.

    McGill University Health Centre, Montreal, Canada.

    Study purpose: We evaluated short-term clinical and immunological outcomes of kidney transplant recipients who received alemtuzumab induction and a steroid-avoidance protocol.Methods: This is a retrospective…
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