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Articles tagged "Induction therapy"

  • 2017 American Transplant Congress

    Clinical and Pathologic Characteristics of Acute Rejection After Alemtuzumab Induction in Kidney Transplant Recipients.

    P. Zhang,1 H. Amer,2 C. Schinstock,2 M. Alexander,1 F. Cosio,2 M. Stegall,3 L. Cornell.1

    1Anatomic Pathology, Mayo Clinic, Rochester; 2Nephrology, Mayo Clinic, Rochester; 3Transplant Surgery, Mayo Clinic, Rochester

    Background: Alemtuzumab induction (AZI) can be used for early steroid withdrawal in kidney transplant (KTx) recipients. There is evidence that AZI-induced lymphocyte depletion leads to…
  • 2017 American Transplant Congress

    The Outcome of 0 Mismatch Kidney in Pediatric Population with High Immunologic. The Impact of Induction Therapy. An Analysis of UNOS Database.

    V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.

    Surgery, State University New York, Syracuse, NY

    Background: 0 mismatch kidneys have superior outcomes in primary transplant recipient. We performed Analysis UNOS database to determine the outcome of high PRA transplant pediatric…
  • 2017 American Transplant Congress

    Does Choice of Induction Agent Affect Outcomes in Kidney Transplants from Deceased Donors with Acute Kidney Injury and Prolonged Cold Ischemia Time?

    G. Dube, S. Mohan, M. Chiles.

    Nephrology, Columbia University Medical Center, New York, NY

    Kidneys with acute kidney injury (AKI) have a higher rate of DGF but similar outcomes to kidneys without AKI, although most data are with kidneys…
  • 2017 American Transplant Congress

    Liver Transplantation Outcomes Using Anti-Thymocyte Globulin Induction in Patients with Autoimmune Hepatitis.

    S. LeCorchick, A. Sharma, I. Yakubu, C. Bhati, T. Reichman, L. Kang, M. Levy.

    Transplantation Surgery, Virginia Commonwealth University, Richmond, VA

    Background: The use of rabbit anti-thymocyte globulin (ATG) induction in high immunological risk patients with autoimmune hepatitis (AIH) could lower the rejection rates after liver…
  • 2017 American Transplant Congress

    Understanding the Role of Induction Agents in Older versus Younger Kidney Transplant Recipients.

    Q. Huang, F. Ammary, M. McAdams-DeMarco, D. Segev.

    Johns Hopkins University, Baltimore, MD

    Background: There has been an increase in the number of older (over 65) KT recipients. Aging-related changes such as differences in immune senescence may influence…
  • 2017 American Transplant Congress

    Renal Transplant Patient Outcomes Following Plasmapheresis, Thymoglobulin, and Rituximab Induction for High Risk DSA Positive Recipients.

    E. Lessmann,1 M. Moaddab,1 M. Manson,1 A. Ram,2 R. Kerman,2 P. Jindra.2

    1Pharmacy, CHI St. Luke's Health Baylor St. Luke's Medical Center, Houston, TX; 2Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX

    Background: Kidney transplantation is associated with improved survival and quality of life relative to dialysis for patients with end-stage renal disease (ESRD). Patients who are…
  • 2017 American Transplant Congress

    De Novo Malignancy Occurrence After Kidney Transplantation in HLA-Sensitized Patients Treated with B-Cell Targeting Therapy.

    L. Couzi,1,2,3 P. Davis,1 J. Visentin,1,2,3 B. Taton,1 G. Guidicelli,1 H. Kaminski,1,2,3 P. Merville,1,2,3 T. Bachelet.4

    1CHU de Bordeaux, Bordeaux, France; 2Université de Bordeaux, Bordeaux, France; 3UMR CNRS 5164 Immunoconcept, Bordeaux, France; 4Clinique Saint-Augustin-CTMR, Bordeaux, France

    Management of high risk transplantations in patients with preformed DSA still remains a dilemma. Many groups propose to increase the immunosuppression in these patients by…
  • 2017 American Transplant Congress

    Impact of T-Cell Depletion on CMV-Specific Memory T and B Cell Homeostatic Proliferation After Kidney Transplantation.

    M. Jarque,2 S. Luque,2 E. Crespo,2 E. Melilli,1 J. Torras,1,2 J. Grinyó,1,2 O. Bestard.1,2

    1Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; 2Nephrology Laboratory, IDIBELL, Barcelona, Spain

    Human CMV infection is the most common opportunistic infection after kidney transplantation, with a negative impact on kidney allograft outcome. Transplant recipients are at higher…
  • 2017 American Transplant Congress

    Alemtuzumab Induction Is Safe, and Permits the Avoidance of Steroids in the Majority of Renal Transplant Recipients.

    A. Seitz,1 M. Robb,2 N. Ahmad,1 A. McLean,3 D. Taube,3 R. Johnson,2 R. Baker.1

    1Renal Unit, St James's Hospital, Leeds, United Kingdom; 2Organ Donation and Transplantation Studies, NHS Blood and Transplant, Bristol, United Kingdom; 3West London Renal and Transplant, Hammersmith Hospital, London, United Kingdom

    IntroductionThe introduction of alemtuzumab into routine clinical use has been hindered by safety concerns surrounding its prolonged effect on the lymphoid compartment. Here we report…
  • 2017 American Transplant Congress

    Benefits of Induction in Recipients of Acute Renal Failure Donor Kidneys.

    M. Barrett, A. Smith, K. Woodside, R. Sung.

    University of Michigan, Ann Arbor

    Kidneys from donors with acute renal failure (ARF) are often discarded due to concerns for DGF and graft failure. Induction immunosuppression can be used to…
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