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Articles tagged "Induction therapy"

  • 2018 American Transplant Congress

    Age Stratified Efficacy and Safety Outcomes of Induction Immunosuppression in Renal Transplantation

    D. McKimmy,1 H. Kuzaro,2 S. Sakya,3 K. Belfield,1 E. Cohen.1

    1Solid Organ Transplant, Yale New Haven Hospital, New Haven, CT; 2University of St. Joseph School of Pharmacy, West Hartford, CT; 3University of Connecticut School of Pharmacy, Storrs, CT.

    Purpose: Rejection and infection remain a leading concern for decreased graft survival after renal transplant (RT). Induction immunosuppression is associated with a decreased risk of…
  • 2018 American Transplant Congress

    Clinical and Pathological Findings in Hepatitis C Positive Renal Transplant Recipients Following Alemtuzumab Induction

    S. Jonchhe, J. Husson, A. Haririan, B. Ravichandran.

    University of Maryland Medical Center, Baltimore.

    BackgroundHistorically, renal transplant recipients (RTRs) with chronic hepatitis C (HCV) have worse long-term outcomes. Induction with alemtuzumab (ALM) in HCV positive RTRs has been postulated…
  • 2018 American Transplant Congress

    Induction Type and Outcomes in HLA-DR Mismatch Kidney Transplantation

    K. Sureshkumar, S. Hussain, B. Chopra.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    In kidney transplantation, donor-recipient HLA-DR mismatch is considered high immunologic risk portending inferior outcomes. We sought to explore the impact of induction type used on…
  • 2018 American Transplant Congress

    Successful Transplantation in a Sensitized Patient Allergic to Commercially Available Antibody Induction Agents

    K. Venkatachalam, A. Malone.

    Transplant Nephrology, Washington University, St. Louis, MO; Transplant Nephrology, Washington University, St. Louis, MO.

    Antibody induction in renal transplantation has increased to over 80%. Rabbit anti-thymocyte globulin (rATG) is the most commonly used agent. Hypotension, rash, dyspnea with rATG…
  • 2018 American Transplant Congress

    Deceased Donor Urinary Biomarker Signature and the Effectiveness of Peritransplant Lymphocyte Depletion on Early Renal Allograft Function

    S. Bernd,2 P. Heeger,1 T-.P. Heather,3 I. Hall,7 M. Doshi,4 F. Weng,5 P. Reese,6 C. Parikh.3

    1Icahn School of Medicine Mount Sinai, New York, NY; 2University of Ulm, Ulm, Germany; 3Yale University School of Medicine, New Haven, CT; 4Wayne State University, Detroit, MI; 5Barnabas Health, Livingston, NJ; 6University of Pennsylvania, Philadelphia, PA; 7University of Utah School of Medicine, Salt Lake City, UT.

    Purpose: Delayed graft function (DGF) is associated with increased allogaft immunogenicity and decreased long-term survival. We hypothesized that high levels of donor urinary biomarkers for…
  • 2018 American Transplant Congress

    Differences in Rejection and Clinical Outcomes in Obese versus Non-Obese Renal Transplant Recipients Receiving Basiliximab Induction Immunosuppression

    J. Benken,1 C. Kane,2 A. Lichvar,1 E. Benedetti.1

    1University of Illinois at Chicago, Chicago, IL; 2University of Northwestern Memorial Hospital, Chicago, IL.

    Introduction: Basilixiab is a fixed-dose IL-2 receptor antagonist that is used for non-lymphodepleting induction therapy. The impact of obesity on basiliximab pharmacokinetics and pharmacodynamics is…
  • 2018 American Transplant Congress

    Single Reduced Dose Thymoglobuline as Induction in Kidney Retransplant

    K. Linhares-Silva, M. Cristelli, L. Viana, C. Felipe, H. Proença, R. de Marco, J. Medina-Pestana, H. Tedesco Silva J�nior.

    Hospital do Rim, São Paulo, Brazil.

    IntroductionKidney retransplant is a high risk procedure, without a consensus about the best induction imunnossupression strategy. Only a few studies have evaluated these growing proportion…
  • 2018 American Transplant Congress

    Basiliximab Induction in HIV-Positive Renal Transplant Recipients Compared to an HIV-Negative Cohort

    J. Schulte,1 C. Richardson,1 V. Stosor,2 K. Cunningham,1 C. D'Agostino,1 C. Kane.1

    1Pharmacy, Northwestern Memorial Hospital, Chicago; 2Infectious Diseases and Organ Transplantation, Northwestern Memorial Hospital, Chicago.

    Purpose: There is an elevated risk of acute rejection in HIV+ renal transplant recipients and continued evaluation of the most appropriate induction therapy remains. Use…
  • 2018 American Transplant Congress

    A Meta-Analysis for Induction Therapy of Kidney Transplantation: Comparison of Antithymocyte Globulin and Interleukin 2 Receptor Antagonist

    G. Chen, Z. Wu, C. Wang, X. Liu, C. Wang, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Objectives To compare the efficacy and safety of antithymocyte globulin (ATG) and interleukin 2 receptor antagonist (IL2Ra) in induction therapy of kidney transplantation.Method A literature…
  • 2018 American Transplant Congress

    Improved Value with Individualized Antithymocyte Globulin Dosing Protocol in Renal Transplant

    J. Dann, W. Ally, M. Bradley, J. Geyston, A. Agarwal.

    University of Virginia Healthsystem, Charlottesville, VA.

    Medication costs represent one of the largest costs associated with transplantation. With growing pressure to reduce health care costs while maintaining excellent outcomes, this study…
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