Articles tagged "Induction therapy"

2019 American Transplant Congress
Reduced Intensity Induction Therapy in Patients Undergoing Repeat Kidney Transplants
K. Linhares, M. Cristelli, C. Felipe, L. Viana, H. Proença, R. E. de Marco, J. Pestana, H. Tedesco
Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil
*Purpose: We hypothesized that patients without donor-specific antibodies (DSA) undergoing repeat transplants could receive lower doses of antithymocyte globulin induction (rATG), without compromising efficacy and…
2019 American Transplant Congress
Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG
R. Schmitz¹, M. S. Mulvihill¹, P. M. Schroder¹, Z. Fitch¹, F. Leopardi¹, D. Magnani², J. Kwun¹, S. J. Knechtle¹, A. D. Kirk¹
¹Surgery, Duke University Medical Center, Durham, NC, ²University of Massachusetts Medical School, Boston, MA
*Purpose: Antithymocyte globulins (ATG) have been used in transplantation since the late 1960s to prevent and treat acute allograft rejection. Over the past decade, induction…
2019 American Transplant Congress
Outcomes of Reduced Thymoglobulin Induction Dosing in Elderly Kidney Transplant Recipients at a Steroid Sparing Center
E. C. Liu, J. H. Lee, R. Abramova
Pharmacy, NewYork-Presbyterian, New York, NY
*Purpose: Studies have demonstrated a mortality benefit with kidney transplantation (KT) in elderly patients, but there is little consensus over optimal immunosuppression. Older KT recipients…
2019 American Transplant Congress
Fatal Graft versus Host Disease in Liver Transplantation. An Analysis of UNOS Registry
S. Nagai¹, A. Yoshida¹, R. Salgia², M. Abouljoud¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Graft-versus-host disease (GVHD) after liver transplant is a rare complication. This study aimed to analyze the UNOS registry to identify risk factors for fatal…
2019 American Transplant Congress
Impact of Induction Choice and Early Steroid Withdrawal on Outcomes in HLA Zero Mismatched Kidney Transplant Recipients
C. Votruba¹, K. Holdener¹, B. Astor², F. Aziz², D. Mandelbrot²
¹Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, WI, ²Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI
*Purpose: Ideal induction and immunosuppression therapy for 6-antigen HLA matched deceased and living kidney transplant recipients (KTR) is not well understood.*Methods: All 6-antigen HLA matched…
2019 American Transplant Congress
Low Dose Anti-Thymocyte Globulin is Enough to Prevent Acute Cellular Rejection in Kidney Transplant
P. W. Baron¹, J. Weissman², F. Fazeli³, C. Zuppan⁴, R. Villicana³, P. Wai¹, L. Beeson⁵, M. De Vera¹
¹Surgery/Transplantation Institute, Loma Linda University Health, Loma Linda, CA, ²Pharmacy, Loma Linda University Health, Loma Linda, CA, ³Transplantation Institute, Loma Linda University Health, Loma Linda, CA, ⁴Pathology, Loma Linda University Health, Loma Linda, CA, ⁵Center for Nutrition, Healthy Lifestyle and Disease Prevention/School of Public Health, Loma Linda University Health, Loma Linda, CA
*Purpose: Rabbit anti-thymocyte globulin (rATG) cumulative dose needed to effectively and safely prevent acute cellular rejection is unknown. This study compares the efficacy of total…
2019 American Transplant Congress
Induction Immunosuppression Practices in Liver Transplantation are Variable and Predict Post-Transplant Survival
T. Bittermann¹, R. Hubbard², J. Lewis¹, D. Goldberg¹
¹Gastroenterology, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Unlike in other solid organ transplants, the benefits of induction immunosuppression prior to liver transplantation (LT) remain uncertain. The objective of this study was…
2019 American Transplant Congress
Hope in Action: A Multicenter Prospective Study of HIV to HIV Kidney Transplantation
C. Durand¹, S. Huprikar², M. Bowring³, D. Brown¹, B. Haydel⁴, N. Desai³, F. Naqvi¹, R. Friedman-Moraco⁵, N. Turgeon⁶, V. Stosor⁷, J. Charette⁷, S. Mehta⁸, J. Husson⁹, A. Gilbert¹⁰, M. Cooper¹¹, C. Butkus-Small¹², G. Gupta¹³, S. Mehta¹⁴, O. Adebiyi¹⁵, P. Chin-Hong¹⁶, P. Stock¹⁷, A. Massie³, S. Florman⁴, D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Medicine, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, Mount Sinai, New York, NY, ⁵Medicine, Emory University, Atlanta, GA, ⁶Surgery, Emory University, Atlanta, GA, ⁷Medicine, Northwestern University, Chicago, IL, ⁸Medicine, University of Alabama, Birmingham, AL, ⁹Medicine, University of Maryland, Baltimore, MD, ¹⁰Medicine, Georgetown University, Washington DC, DC, ¹¹Department of Surgery, Georgetown University, Washington DC, DC, ¹²Medicine, Cornell University, New York, NY, ¹³Medicine, Virginia Commonwealth University, Richmond, VA, ¹⁴Medicine, New York University, New York, NY, ¹⁵Medicine, Indiana University, Indianapolis, IN, ¹⁶Medicine, University of California at San Francisco, San Francisco, CA, ¹⁷Surgery, University of California at San Francisco, San Francisco, CA
*Purpose:HIV+ donor to HIV+ recipient (HIV D+/R+) kidney transplantation (KT) has had success in South Africa. Expansion of this practice in the US setting of…
2019 American Transplant Congress
Early Rejection Outcomes with IL-2 vs. ATG Induction among Kidney Transplant Recipients Induction Differences with Early Steroid Withdrawal
C. Burelli, A. Szczepanik, K. Yadav, E. Sanchez, M. Debroy, V. Humphreville, J. Rabets, A. Padiyar, N. Sarabu, A. Jittirat, A. Palanisamy, K. Chavin
University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Early steroid withdrawal in kidney transplant (Ktx) patients is controversial and has demonstrated an increased risk of acute rejection with similar long-term outcomes. Data…
2019 American Transplant Congress
Basiliximab vs. Low-Dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients: Prospective Randomized Study in Southeastern Mexico
G. Martinez-Mier, P. I. Moreno-Ley, L. F. Budar-Fernandez, M. T. Mendez-Lopez, D. A. Barrera-Amoros, M. De la Paz-Roman, L. A. Jimenez-López, E. G. Aguilar-Sandoval, C. A. Allende-Castellanos
Organ Transplantation & Research, IMSS UMAE HE 14, Veracruz, Mexico
*Purpose: Demonstrate that low dose Thymoglobulin (3 mg/kg total ) has similar efficacy (DGF, SGF, BPAR, hospitalizations, adverse events, graft loss and death) than Basiliximab…