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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    BK Viremia in Living vs Deceased Donor Renal Transplant Recipients Receiving Alemtuzumab Induction

    J. P. Casale1, D. Pluckrose1, A. Haririan2, T. Sparkes1

    1University of Maryland Medical Center, Baltimore, MD, 2Univ of Maryland Schl of Med, Baltimore, MD

    *Purpose: There is conflicting data regarding the association of donor type and BK viremia in renal transplant recipients. This study sought to compare the incidence…
  • 2022 American Transplant Congress

    Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade

    K. L. Alexander, D. Liu, M. L. Ford

    Emory University Transplant Center, Emory University, Atlanta, GA

    *Purpose: CD154 pathway antagonism has shown to be a promising target for inducing long-time graft survival, in some cases showing efficacy that is superior to…
  • 2022 American Transplant Congress

    External Validation of the Abbreviated Ibox Scoring System at One-Year Post Kidney Transplant as a Surrogate Endpoint for Death-Censored Graft Survival

    A. Klein1, L. Kosinski2, R. Muse2, A. Loupy3, O. Aubert3, G. Divard3, M. Stegall4, I. Helanterä5, W. E. Fitzsimmons1, I. O'Doherty1

    1Transplant Therapeutics Consortium, Critical Path Institute, Tucson, AZ, 2Critical Path Institute, Tucson, AZ, 3Paris Transplant Group, Paris, France, 4Mayo Clinic, Rochester, MN, 5Helsinki University Hospital, Helsinki, Finland

    *Purpose: The Transplant Therapeutics Consortium seeks to translate the iBox from Loupy et al., 2019 into a surrogate endpoint for five-year death-censored graft survival after…
  • 2022 American Transplant Congress

    Low Fixed Tacrolimus Starting Dose and the Correlation with Renal Allograft Rejection

    R. Davoudi, E. Kitchel, S. Lee, T. Tan, T. Sievers, S. Bunnapradist

    David Geffen School of Medicine, Los Angeles, CA

    *Purpose: Achieving a tacrolimus therapeutic trough concentration (C0) by post-operative day (POD) 3-7 has been associated with a reduced risk for rejection. Although FDA prescribing…
  • 2022 American Transplant Congress

    Impact of Early Calcineurin-Inhibitor Conversion to Belatacept on Renal Allograft Function in a Steroid-Free Maintenance Regimen: Results from a Randomized Controlled Study

    I. Tawhari1, P. Hallak1, S. Hartzell2, V. Mas3, P. Cravedi2, J. Leventhal1, J. Ansari1, L. Gallon1

    1Northwestern University, Chicago, IL, 2Mount Sinai, New York, NY, 3University of Maryland, Baltimore, MD

    *Purpose: Belatacept (Bela) was developed to minimize nephrotoxicity and cardiovascular risk associated with Calcineurin inhibitors (CNIs). Early steroid withdrawal (ESW) and simultaneous CNI avoidance (CNIA)…
  • 2022 American Transplant Congress

    Pegloticase Use in Renal Transplant Recipients with Gout: Findings from an Insurance Claims Database Study

    C. A. Shadur1, B. Marder2, C. Vesel2, B. LaMoreaux2

    1Iowa Kidney Physicians, Des Moines, IA, 2Horizon Therapeutics plc, Deerfield, IL

    *Purpose: Kidney transplant (KT) recipients have high gout incidence due to reduced eGFR and medication use associated with hyperuricemia.1 Oral urate-lowering therapies in KT patients…
  • 2022 American Transplant Congress

    Comparing The Immunologic Responses Between Kidney Transplant Recipients Receiving Standard Immunosuppression And CNI Reduction After Two Doses Of ChAdOx-1 And A Booster Dose BNT162b2

    S. Phirom1, T. Kitrungphaiboon2, W. Jantarabenjakul2, Y. Avihingsanon2, W. Prasithsirikul3, J. Vanichanan4, P. Hansasuta5, N. Townamchai6

    1Nephrology division, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 2King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 3Bamrasnaradura infectious disease institute, Bangkok, Thailand, 4Infectious diseases, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 5Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 6Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

    *Purpose: Immunosuppression can impair immunological responses after vaccination in kidney transplant recipients (KTR). However, little is known about the effect of the booster dose of…
  • 2022 American Transplant Congress

    Recipient and Center Factors Associated with Immunosuppression Practice Beyond the First Year After Liver Transplantation

    T. Bittermann1, D. Goldberg2

    1University of Pennsylvania, Philadelphia, PA, 2University of Miami, Miami, FL

    *Purpose: To investigate patient and center factors associated with differences in immunosuppression management in the first 5 years after LT.*Methods: A retrospective cohort of 11,326…
  • 2022 American Transplant Congress

    Association Between Time in Therapeutic Range for Warfarin and Time in Therapeutic Range for Calcineurin Inhibitors in Patients That Received Left Ventricular Assist Devices as Bridge to Transplant

    G. Flajc1, X. Huang2, C. Minard2, M. Manson1, Z. Truman1

    1Baylor St. Luke's Medical Center, Houston, TX, 2Baylor College of Medicine, Houston, TX

    *Purpose: Medication nonadherence is a leading cause of avoidable graft failure post-transplant. The relationship between medication adherence in patients with left ventricular assist devices (LVADs)…
  • 2022 American Transplant Congress

    Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients

    K. Deng1, N. Tanimine2, C. Breeden3, B. Burrell3, G. Gaile3, K. Lee1, R. Matheson1, F. Qiang1, C. Rickert1, C. LeGuern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, 3Immune Tolerance Network, Bethesda, MD

    *Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
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