Articles tagged "Immunosuppression"

2018 American Transplant Congress
Once-Daily MeltDose Tacrolimus Formulation and Renal Function in Caucasian Fast Tacrolimus Metabolizers: Does Early Identification Have an Impact in PK Sensitive Patients?
K. Budde,⁶ B. Suwelack,¹ D. Stevens,³ W. Du,⁴ C. Procaccianti,⁵ C. Maas,⁵ S. Bunnapradist.²
¹University Hospital of Münster, Münster, Germany; ²David Geffen School of Medicine at UCLA, Los Angeles; ³Veloxis Pharmaceuticals, Cary; ⁴Clinical Statistics Consulting, Norrystown; ⁵Chiesi Farmaceutici S.p.A., Parma, Italy; ⁶Charité Universitatsmedizin, Berlin, Germany.
Tacrolimus (TAC) nephrotoxicity can be seen even at low blood trough levels, with factors beyond trough levels potentially contributing. TAC fast metabolizers have higher Cmax,…
2018 American Transplant Congress
Development of Optimal Simplified Equation for Estimation of Mycophenolic Acid Exposure Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients
W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.
MyERA Study Group, Hangzhou, China.
Background: Limited sampling strategies (LSS) aids in overcoming the complexity of extensive PK sampling and supporting the calculation of mycophenolic acid (MPA) exposure. This study…
2018 American Transplant Congress
Effects of Medication Education Pilot Program in Living versus Deceased Donor Kidney Transplant Recipients.
N. Sulejmani, H. Albanna, B. Summers, A. Jantz, R. Prashar, A. Patel.
Henry Ford Transplant Institute, Detroit, MI.
Purpose: Medication adherence is crucial for transplant recipients as non-adherence can result in increased risk of rejection and graft loss. Early education prior to transplant…
2018 American Transplant Congress
Activation Requirements of Costimulation Blockade-Resistant CD4 T Cells
J. Espinosa, B. Adams, J. Kearns, F. Shaw, R. Osborne, T. Woody, M. Ellis, J. Cheeseman, A. Kirk.
Duke University, Durham.
T cells lose costimulation dependence following primary activation and many phenotypes of terminally differentiated cells have been identified as contributing to costimulation blockade (CoB)-resistant rejection…
2018 American Transplant Congress
Improvement in Intermediate Graft Survival among Deceased Donor Recipients in the Last Decade Due to Improvements in Outcomes of Higher KDPI Kidney Recipients
D. Keith.
Medicine, Sacred Heart Hospital, Pensacola, FL, Turkey.
Previous research by our group showed that intermediate graft survival of adult deceased donor kidney transplants between six months and three years post-transplant improved in…
2018 American Transplant Congress
Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts
T. Yamamoto,¹ H. Hara,¹ L. Wang,¹ Q. Li,¹ J. Li,¹ H. Zhou,¹ D. Eckhoff,¹ A. Tector,¹ D. Ayares,² D. Cooper,¹ H. Iwase.¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; ²Revivicor, Blacksburg.
Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
2018 American Transplant Congress
Induction Agents and Post-Transplant Malignancies in Kidney Transplants: An Examination of Outcomes at a Large Volume Center over 20 Years
D. Livingston-Rosanoff, X. Wang, G. Leverson, D. Kaufman, D. Foley.
Division of Transplant Surgery, University of Wisconsin, Madison, WI.
Introduction: Induction agents have a profound effect on the immune milieu at the time of kidney transplantation. However, evaluation of their long-term effects on graft…
2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…
2018 American Transplant Congress
Contemporary Desensitization with Low Dose Rituximab Ensures Kidney Transplant Outcome beyond ABO Blood Type Incompatibility:A Comparison between past Regimens in Single Institute
H. Harada, Y. Wada, A. Mitsuke, T. Hirose, N. Fukuzawa, T. Seki.
Kidney Transplant Surgery and Urology, Sapporo City General Hospital, Sapporo, Japan.
INTRODUCTION: An ABO incompatible kidney transplant (ABOiKT) requires desensitization (DS). The ways of DS have been changed chronologically and the outcome could have been subsequently…
2018 American Transplant Congress
Experience with Alemtuzumab Induction with Tacrolimus/Mycophenolate +/- Steroids in Simultaneous Pancreas-Kidney Transplant Recipients with Portal-Enteric Drainage
D. Harriman, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta.
Surgery, Medicine, Pathology, Pharmacy, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Introduction: Simultaneous pancreas-kidney transplant (SPKT) recipients are a relatively homogeneous population that are considered high immunological risk because of younger age, presumed autoimmune etiology of…