Articles tagged "Immunosuppression"

2018 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
J. Etra,¹ K. Cilwa,² G. Furtmueller,¹ A. Leto Barone,¹ K. Kolegraff,¹ E. Elster,¹ W. Lee,¹ G. Brandacher.¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Naval Medical Research Center, Silver Springs, MD; ³Department of Surgery, Uniformed Services, University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.
PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…
2018 American Transplant Congress
The Impact of Immunosuppression on Mineral Metabolism One Year after Kidney Transplantation: Differences between a Mycophenolate-Based Regimen versus an mTOR-Inhibitor-Based One
D. Cucchiari,¹ S. Karam,² P. Ventura-Aguiar,¹ F. Diekmann,¹ J. Torregrosa.¹
¹Renal Transplant Unit, Hospital Clinic, Barcelona, Spain; ²Department of Medicine, Saint George Hospital University Medical Center, Beirut, Lebanon.
INTRODUCTION: after kidney transplantation, a substantial amount of patients still suffer from Mineral Bone Disorder. The role of different immunosuppressive therapies on mineral metabolism in…
2018 American Transplant Congress
Galangin Promotes Treg Development and Function
F. Liang,¹ H. Fang,¹ R. Zhang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Introduction: FoxP3+ Treg cells are central in controlling immune responses and transplant tolerance. CD73 (ecto-5'-nucleotidase), which serves to convert AMP to adenosine, is essential for…
2018 American Transplant Congress
Successful Transplantation in a Sensitized Patient Allergic to Commercially Available Antibody Induction Agents
K. Venkatachalam, A. Malone.
Transplant Nephrology, Washington University, St. Louis, MO; Transplant Nephrology, Washington University, St. Louis, MO.
Antibody induction in renal transplantation has increased to over 80%. Rabbit anti-thymocyte globulin (rATG) is the most commonly used agent. Hypotension, rash, dyspnea with rATG…
2018 American Transplant Congress
Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplantation
A. Thomson, A. Humar, F. Lakkis, S. Styn, A. Zahorchak, C. Macedo, D. Metes.
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Purpose: We have embarked on a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation…
2018 American Transplant Congress
Long-Term Efficacy and Safety of Everolimus Based Immunosuppression on De Novo Kidney Transplantation with 9 Years Follow-Up
S. Narumi,¹ Y. Watarai,¹ N. Goto,² T. Hiramitsu,¹ M. Okada,¹ M. Tsujita,² K. Futamura,² M. Nishihira,³ T. Kobayashi.⁴
¹Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; ²Transplant Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; ³Nephrology, Masuko Memorial Hospital, Nagoya, Aichi, Japan; ⁴Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
Purpose: Long-term efficacy and safety of everolimus (EVR) based immunosuppression for de novo kidney transplant recipient who were involved in A1202 study was evaluated in…
2018 American Transplant Congress
Novel Low Dosing of Rabbit Antithymocyte Globulin Preserves Excellent Outcomes and Improves the Value of Care in Low Risk Renal Transplantation
J. Dann, W. Ally, M. Bradley, J. Geyston, A. Agarwal.
University of Virginia Health System, Charlottesville, VA.
Elderly and non-sensitized renal transplant patients may benefit from lesser induction immunosuppression. This study evaluates three year clinical outcomes of a low risk renal transplant…
2018 American Transplant Congress
Adjunctive Corticosteroid Immunosuppression Improves Hyperbilirubinemia Following Liver Transplantation (OLT)
G. Malat, D. Reich, G. Xiao, M. Harhay, K. Ranganna, D. Lee, S. Guy, S. Munoz.
Drexel University, Philadelphia.
Background: Deceased donor orthotopic liver transplantation (OLT) can result in significant delayed function, manifesting as protracted hyperbilirubinemia, depending on the intensity of the ischemia/reperfusion injury…
2018 American Transplant Congress
Mycophenolic Acid Reduces BK Polyomavirus Replication in an In Vitro Model of Renal Tubular Epithelial Cells Infection
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Background. BK virus (BKV) nephropathy is an important cause of allograft failure after kidney transplant. Immunosuppression is a recognized risk factor for BKV replication but…
2018 American Transplant Congress
Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study
S. Mulgaonkar,¹ Y. Qazi,¹ D. Kim,¹ V. Peddi,¹ K. McCague,² D. Patel,² A. Wiseman.¹
¹TRANSFORM Study Group, Livingston; ²Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…