Articles tagged "Immunosuppression"

2019 American Transplant Congress
Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice
Y. Matsuda
Osaka University Graduate School of Medicine, Osaka, Japan
*Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
2019 American Transplant Congress
Relationship between Comorbilities and Infectious Disease in Kidney Transplant Recipients Receiving Rituximab
A. Molina-Andújar¹, E. Hermida¹, J. Rovira², F. Cofan¹, P. Ventura-Aguiar¹, N. Esforzado¹, V. Torregrosa¹, D. Cucchiari¹, E. de Souza¹, I. Revuelta¹, F. Oppenheimer¹, F. Diekmann¹, G. Piñeiro¹
¹Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain
*Purpose: Rituximab is commonly used in the context of kidney transplantation. Evidence about infectious complications and its relationship with predictive factors is scarce. The aim…
2019 American Transplant Congress
Blood Group Incompatible Living Donor Kidney Transplantation in Patients with End-Stage Kidney Disease Due to Diabetes Kidney Disease
J. Uchida¹, A. Kosoku¹, K. Kabei¹, S. Nishide¹, H. Shimada¹, K. Maeda², Y. Yoshikawa³, T. Iwai¹, N. Kuwabara¹, T. Naganuma¹, N. Kumada⁴, Y. Takemoto¹, T. Nakatani¹
¹Urology, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Nursing, Osaka City University Hospital, Osaka, Japan, ³Osaka City University, Osaka, Japan, ⁴Urology, Suita Municipal Hospital, Suita, Japan
*Purpose: Diabetes is a growing public health problem, and diabetes kidney disease (DKD) is the most prevalent chronic kidney disease and the major cause of…
2019 American Transplant Congress
Neutralization of Interlukin-6 by ALD518-P18 (Murine Clazakizumab) Attenuates Donor Specific Antibody Responses in a Mouse Model of Allogeneic Sensitization: A Report of Dosage Finding Study
I. Kim, G. Wu, N. Chai, T. Brennan, A. Klein, S. Jordan
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Interleukin-6 (IL-6) is a proinflammatory cytokine involved in mediating both T-cell and B-cell responses in allograft rejection. In previous studies, we demonstrated that inhibition…
2019 American Transplant Congress
Early Diagnosis of BK Virus Nephropathy Can Retrieve Kidney Allografts by Simple Reduction in Immunosuppressive Agents
N. Iwahara, D. Iwami, K. Hotta, H. Okada, N. Shinohara
Hokkaido Univercity, Sapporo, Japan
*Purpose: Although BK virus nephropathy (BKVN) is a major complication after kidney transplant leading to graft loss, it is often difficult to diagnose and treat.…
2019 American Transplant Congress
The Immunomodulatory Role of Type I Interferons in Alloimmunity
I. Sulkaj, H. Allos, S. K. Eskandari, J. M. Safadi, J. Y. Choi, B. S. Al Dulaijan, E. Al-Hussain, S. Cai, J. R. Azzi
Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…
2019 American Transplant Congress
Genome-Wide Profiling of BK Polyomavirus Integration in Urothelial Carcinoma of Kidney Transplant Recipients Reveals a Potential Microhomology or Nonhomologous End Joining Mediated Integration Mechanism
Y. Jin¹, Y. Zhou¹, W. Deng¹, R. Lee², Y. Liu¹, M. Blute³, R. Liu¹, N. Elias⁴, F. Fu¹, B. Guan¹, J. Geng¹, J. Ma⁵, J. Zhou⁵, N. Liu⁵, C. Wu⁶, Y. Miao¹
¹Nanfang Hospital, Southern Medical University, Guangdzhou, China, ²Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Departments of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Mygenostics Co., Beijing, China, ⁶Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Chronic BK polyomavirus (BKV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Besides, a positive correlation…
2018 American Transplant Congress
Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study
S. Mulgaonkar,¹ Y. Qazi,¹ D. Kim,¹ V. Peddi,¹ K. McCague,² D. Patel,² A. Wiseman.¹
¹TRANSFORM Study Group, Livingston; ²Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…
2018 American Transplant Congress
Approaches to Prevention of Antibody Rebound after HLA Sensitization in a Mouse Model
I. Kim, G. Wu, N-.N. Chai, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Control of donor specific antibodies (DSA) is critical for prevention of antibody mediated rejection (ABMR). Removal of DSAs with PLEX often results in significant…
2018 American Transplant Congress
Early Steroid Withdrawal and Kidney Transplant Outcomes for Recipients with Delayed Graft Function
S. Bae, A. Massie, X. Luo, J. Garonzik Wang, D. Segev.
Johns Hopkins, Baltimore, MD.
Current guidelines suggest early steroid withdrawal (ESW) regimen for kidney transplant (KT) recipients with low immunological risk. Delayed graft function (DGF) is a risk factor…