Articles tagged "Immunosuppression"

2019 American Transplant Congress
CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation
J. E. Kimpton, A. J. Hughes, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
2019 American Transplant Congress
A Retrospective Observational Analysis of Tacrolimus Metabolism Rate: No Evidence for Impact on Renal Function
A. J. Hughes, J. E. Kimpton, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: A previous publication found that fast metabolisers of tacrolimus had inferior renal function compared to slow metabolisers in a Caucasian population (Thölking et al.,…
2019 American Transplant Congress
Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients
S. Sullivan¹, K. N. Triplett¹, C. Sacks², M. Tran², D. M. Desai³
¹Solid Organ Transplant, Children's Medical Center, Dallas, Dallas, TX, ²Proteus Digital Health, Redwood City, CA, ³Transplant Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
*Purpose: Purpose: Optimal allograft function and long-term graft survival depends on many factors, including adherence to a complex medication regimen. Methods of measuring adherence are…
2019 American Transplant Congress
Prevalence of Varicella Zoster Infection in Renal Transplant Recipients
P. T. Gaynor, D. Nanayakkara, O. E. Beaird, J. Schaenman, S. Bunnapradist
Infectious Diseases, UCLA, Los Angeles, CA
*Purpose: Varicella zoster infection is a serious complication of immunosuppression in renal transplant recipients. We examined the prevalence of VZV infection in renal transplant patients…
2019 American Transplant Congress
Combination of Ketoconazole and Tacrolimus Increases the Risk of Kidney Transplant Rejection in African Americans
M. E. Sharshir, A. Zhang, E. Khan, B. Zhang, S. Giusti, R. Zhang
Nephrology, Tulane University, New Orleans, LA
*Purpose: African American patients generally have a rapid metabolism and thus require higher doses of tacrolimus after kidney transplantation. Ketoconazole inhibits tacrolimus metabolism and can…
2019 American Transplant Congress
Use of Eculizumab for Active Antibody-Mediated Rejection That Occurs Early Post-Kidney Transplantation: A Consecutive Series of 15 Cases
E. Tan¹, B. J. Andrew², P. G. Dean², M. F. Shaheen¹, M. D. Stegall², C. A. Schinstock²
¹Division of Transplantation Surgery, Mayo Clinic Rochester, Rochester, MN, ²The William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic Rochester, Rochester, MN
*Purpose: Active antibody-mediated rejection (ABMR) that occurs during the amnestic response within the first month post-transplant is a rare but devastating cause of early allograft…
2019 American Transplant Congress
Transplant Regimen Adherence For Kidney Recipients By Engaging Information Technologies: The Take It Trial
D. P. Ladner¹, M. S. Wolf²
¹Surgery, Northwestern Medicine, Chicago, IL, ²General Internal Medicine, Northwestern University, Chicago, IL
*Purpose: Several studies report a high prevalence of inadequate adherence to prescribed (Rx) immunosuppressive (IS) medication regimens among kidney transplant (KT) recipients, yet few interventions…
2018 American Transplant Congress
Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts
T. Yamamoto,¹ H. Hara,¹ L. Wang,¹ Q. Li,¹ J. Li,¹ H. Zhou,¹ D. Eckhoff,¹ A. Tector,¹ D. Ayares,² D. Cooper,¹ H. Iwase.¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; ²Revivicor, Blacksburg.
Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
2018 American Transplant Congress
Induction Agents and Post-Transplant Malignancies in Kidney Transplants: An Examination of Outcomes at a Large Volume Center over 20 Years
D. Livingston-Rosanoff, X. Wang, G. Leverson, D. Kaufman, D. Foley.
Division of Transplant Surgery, University of Wisconsin, Madison, WI.
Introduction: Induction agents have a profound effect on the immune milieu at the time of kidney transplantation. However, evaluation of their long-term effects on graft…
2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…