ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    Adverse Effect Differences between Tacrolimus-IR and LCP-Tacrolimus

    J. Hagopian1, C. Carthon1, S. January1, A. Gharabagi2, R. Delos Santos3, T. Horwedel4

    1Barnes-Jewish Hospital, Saint Louis, MO, 2St. Louis College of Pharmacy, Saint Louis, MO, 3Washington Universidy, Saint Louis, MO, 4Veloxis Pharmaceuticals, Inc, Cary, NC

    *Purpose: Extended-release tacrolimus (Envarsus XR®, LCP-Tac) was approved in 2015 as conversion from tacrolimus immediate-release (Tac-IR) as part of the maintenance immunosuppression regiment post-kidney transplant.…
  • 2019 American Transplant Congress

    Costs Associated with A2 to B Kidney Transplantation: A Barrier to Its Utilization?

    R. Forbes, B. Concepcion, D. Shaffer

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: In 2014 the updated Kidney Allocation System (KAS) allowed for allocation of blood type A2 kidneys to B recipients in an effort to ameliorate…
  • 2019 American Transplant Congress

    Store-Operated/Calcium Release Activated Calcium Channel Orai3 is a Novel Target for Immunoregulation

    D. Shankaranarayanan1, M. Lagman1, V. Sharma1, C. Li1, M. Cassidy1, C. Snopkowski1, H. Yang1, T. Muthukumar1, K. Machaca2, M. Suthanthiran1

    1WCMC, New York, NY, 2WCMC, Doha, Qatar

    *Purpose: Store-operated/calcium release activated calcium (CRAC) channels are essential for the signaling of immune cells via calcineurin, a calcium-calmodulin dependent serine-threonine phosphatase. The central importance…
  • 2019 American Transplant Congress

    Cidofovir for BK Nephropathy Rescue Treatment: A Single Center Experience

    J. Slatinska1, E. Honsova2, T. Rohal1, A. Slavcev3, P. Hruba4, O. Viklicky1

    1Nephrology, IKEM, Prague, Czech Republic, 2Pathology, IKEM, Prague, Czech Republic, 3Immunology, IKEM, Prague, Czech Republic, 4Transplant Laboratory, IKEM, Prague, Czech Republic

    *Purpose: Cidofovir is a potentially nephrotoxic antiviral drug used primarily as a treatment for CMV retinitis however due to its potent antiviral effects has been…
  • 2019 American Transplant Congress

    Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft

    E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi

    Teikyo University, Tokyo, Japan

    *Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2019 American Transplant Congress

    The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy

    K. Kamrani1, A. Okoh2, D. Hanos1, M. Camacho1, M. Zucker2, K. Clarke1

    1Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, 2Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ

    *Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…
  • 2019 American Transplant Congress

    Frailty Associated with Increased Rates of Acute Cellular Rejection within 3 Months after Liver Transplantation

    L. Fozouni, A. Lebsack, Y. Mohamad, C. Freise, P. Stock, J. Lai

    UCSF, San Francisco, CA

    *Purpose: Frailty, a state of decreased physiologic reserve and increased vulnerability to health stressors, has an inflammatory biologic basis and has been associated with dysregulation…
  • 2019 American Transplant Congress

    The Evolving Clinical Presentation of Acute Rejection in Face Transplantation

    V. Haug, B. Kollar, D. Obed, H. Kiwanuka, M. Turk, L. Wo, S. Tasigiorgos, M. Kueckelhaus, L. Riella, B. Pomahac

    Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA

    *Purpose: Clinical signs such as erythema or edema are traditionally helpful to diagnose Acute rejection (AR) in face transplantation (FT) in the early follow-up. The…
  • 2019 American Transplant Congress

    Tacrolimus Concentrations Can Be Reliably Measured in Capillary Microsamples

    M. T. Gustavsen, N. Vethe, M. Lauritsen, A. Andersen, A. Åsberg, S. Bergan, K. Midtvedt

    Oslo University Hospital, Rikshospitalet, Oslo, Norway

    *Purpose: Routine therapeutic drug monitoring (TDM) of tacrolimus (Tac) is currently performed in venous bloods samples drawn at the hospital. The novel volumetric absorptive microsampling…
  • 2019 American Transplant Congress

    Immunosuppression after Organ Transplantation Does Not Enhance Patency of Cold-Stored Vein Allografts for Critical Limb Ischemia -Single Centre Experience

    J. Chlupac, T. Marada, R. Novotny, K. Lipar, L. Janousek, J. Fronek

    Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: Sub-inguinal bypass with cold-stored saphenous vein allograft is a last option treatment for extensive peripheral arterial occlusive disease with absent autologous vein. The aim…
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