ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    Combination of Extended-Release Tacrolimus Plus Everolimus Once Daily in De Novo Kidney Transplant Recipients: ER-Tac vs LCPT

    G. Spagnoletti, M. P. Salerno, F. De Gennaro, J. Romagnoli, F. Citterio

    Surgery, Renal Transplant Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    *Purpose: Combination of Everolimus (EVR) with Tacrolimus (Tac) permits reduced calcineurin inhibitors exposure and, recently, has been demonstrated safe and effective. Two different once-daily Tacrolimus…
  • 2019 American Transplant Congress

    CCR5-Mediated Recruitment of NK Cells to the Kidney is a Critical Step for Host Defense to Candida albicans Infection

    H. R. Cho1, V. G. Tran2, N. N. Nguyen3, S. Lee4, S. W. Kang4, J. Kim4, H. J. Kim4, S. J. Park1, J. S. Lee5, B. Kwon6

    1Department of Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, 31School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, 4Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, 5Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of, 6Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Korea, Republic of

    *Purpose: Candida albicans infection causes a high rate of mortality in immunocompromised or transplant patients. In this study, we investigated the role of CCR5 that…
  • 2019 American Transplant Congress

    Approach to Leukopenia in Older Kidney Transplant Recipients

    M. Shearer, M. Labonte, L. Erbe, R. Rodgriuez, A. Price, V. Rao, M. Casey, K. Soliman, D. Lazarus, D. Taber, M. Posadas Salas

    Dept of Medicine, Medical University of South Carolina, Charleston, SC

    *Purpose: Older kidney transplant recipients face challenges of post-transplant complications related to frailty and comorbidity burden. They are particularly vulnerable to side effects of immunosuppression…
  • 2019 American Transplant Congress

    Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation

    S. Tajima1, R. Fu2, M. Fukuda2, K. Suetsugu2, Y. Okabe3, S. Masuda1

    1Pharmacy, Kyushu University Hospital, Fukuoka, Japan, 2Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 3Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    *Purpose: Biopsy proven acute rejection without clinical symptoms such as subclinical rejection (SCR) is supposed to associate graft loss in the long term post kidney…
  • 2019 American Transplant Congress

    Association between CD19-Positive Rate and Antibody-Mediated Rejection Following Rituximab Administration in Kidney Transplant Recipients

    K. Nanmoku, T. Shinzato, T. Kubo, T. Shimizu, T. Yagisawa

    Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan

    *Purpose: Rituximab, which suppresses antibody production, is widely used for desensitization in ABO-incompatible and donor-specific antibody-positive kidney transplantation. However, data regarding the effects of individual…
  • 2019 American Transplant Congress

    Use of Belatacept in Pancreas Transplantation

    P. D. Uva, A. Quevedo, J. Roses, R. Pilotti, E. Chuluyan, D. Casadei

    Kidney/Pancreas Transplantation, ITAC - Nephrology, Buenos Aires, Argentina

    *Purpose: To review our experience with Belatacept in pancreas transplantation*Methods: Retrospective review including all patients receiving Belatacept after pancreas transplantation. Main objective is to review…
  • 2019 American Transplant Congress

    Comparative Use of Single mTOR vs Dual mTOR/PI3K Inhibition in Regulatory T Cell Expansion for Clinical Application in Transplantation

    R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi

    University of Kentucky, Lexington, KY

    *Purpose: Experimental and pre-clinical evidence suggest that adoptive transfer of regulatory T cells (Tregs) could be an appropriate therapeutic strategy to induce tolerance and improve…
  • 2019 American Transplant Congress

    Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center

    J. S. Kerr, N. Law, S. Aslam

    Center for Transplantation, University of California, San Diego Health System, La Jolla, CA

    *Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…
  • 2019 American Transplant Congress

    Impact of Liver Recipient Genotype on Tacrolimus

    S. Tremblay1, T. Fukuda2, T. Mizuno2, A. A. Vinks2, E. Woodle1, J. Klawitter3, J. Klawitter3, U. Christians3, R. R. Alloway1

    1University of Cincinnati, Cincinnati, OH, 2Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, 3iC42 Clinical Research and Development, Aurora, CO

    *Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
  • 2019 American Transplant Congress

    Is Alemtuzumab Induction Safe In Septuagenarians Undergoing Deceased Donor Kidney Transplantation?

    D. Harriman, V. Gurram, C. Jay, J. Rogers, A. Farney, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, R. Stratta

    Wake Forest Baptist Medical Center, Winston-Salem, NC

    *Purpose: Alemtuzumab induction in septuagenarians is controversial but understudied.*Methods: Single center retrospective review of adult deceased donor kidney transplant (KT) recipients receiving single dose (30…
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