ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    The Effect of a Novel Dosing Protocol for the De Novo Use of LCP Tacrolimus in Kidney Transplant Recipients Managed on a Steroid-Free Maintenance Immunosuppression Regimen

    R. Wolff1, A. Nasstrom1, C. Borscheid1, C. Martin1, A. Temelie1, R. Spong2, D. Keys2, T. B. Dunn3

    1School of Pharmacy, MHealth U of MN Medical Center-Fairview, Mpls, MN, 2Medicine, MHealth U of MN Medical Center-Fairview, Mpls, MN, 3Surgery, U of Pennsylvania, Phila, PA

    *Purpose: It is not known if an extended release formulation of tacrolimus (LCPT, Envarsus XR®) can be successfully dosed to achieve an early therapeutic trough…
  • 2019 American Transplant Congress

    A Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients

    T. A. Horwedel1, C. E. Carthon1, S. E. January1, A. Gharabagi1, R. Delos Santos2, J. C. Hagopian1

    1Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, 2Nephrology, Washington University School of Medicine, Saint Louis, MO

    *Purpose: Beginning in December 2015, our center instituted a protocol change moving to de novo use of LCPT. The objective of this study is to…
  • 2019 American Transplant Congress

    Reduction of Pre-Existing Alloantibodies in Highly Sensitized Belatacept-Treated Kidney Recipients

    R. F. Parsons1, S. Bumb2, H. Decker1, A. Zahid1, C. Sullivan1, T. Pearson1, C. Larsen1, M. Levine3, M. Kamoun3, R. A. Bray1, H. M. Gebel1

    1Emory University School of Medicine, Atlanta, GA, 2University of Cincinnati, Cincinnati, OH, 3University of Pennsylvania, Philadelphia, PA

    *Purpose: Recent evidence suggests that belatacept reduces the durability of pre-existing antibodies to class I and class II human leukocyte antigens (HLA). Belatacept has a…
  • 2019 American Transplant Congress

    A Novel Apparatus Mimicking Hypertensive Kidney With Primary Cultured Human Kidney Cells Using Rotational Force: Application To In Vitro Drug Screening In Kidney Transplant Recipients

    Y. Kim1, S. Lee2, J. Moon1, J. Kim1, M. Yu3, C. Lee4, Y. Kim1, S. Yang5, J. Jeong1, J. Seon1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, 3Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, 4Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, 5Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: Cell culture is an essential part of the development for various medical technologies such as identifying the cause of the disease and developing new…
  • 2019 American Transplant Congress

    Incidence, Risk Factors, Outcomes and Clinical Management of BK Viremia in the Modern Era of Kidney Transplantation

    J. Kim

    Toronto General Hospital, Toronto, ON, Canada

    *Purpose: BK viremia is endemic among kidney transplant recipients (KTR). Previous work has not compared the incidence, risk factors, and outcomes of any vs. clinically…
  • 2019 American Transplant Congress

    Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft

    E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi

    Teikyo University, Tokyo, Japan

    *Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2019 American Transplant Congress

    The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy

    K. Kamrani1, A. Okoh2, D. Hanos1, M. Camacho1, M. Zucker2, K. Clarke1

    1Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, 2Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ

    *Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…
  • 2019 American Transplant Congress

    Early Use of Everolimus Plus Reduced Tacrolimus vs Standard Tacrolimus in De Novo Livertransplant Recipients: 12 Months Efficacy and Safety Data from HEPHAISTOS Study

    B. Nashan1, P. Schemmer1, H. Schlitt1, A. Pascher1, C. Klein1, U. Neumann1, I. Kroeger2, P. Wimmer2, F. Braun1

    1Study Group, Hephaistos, Germany, 2Novartis Pharma GmbH, Nuernberg, Germany

    *Purpose: The HEPHAISTOS study was set up to compare early use of everolimus [EVR] combined with reduced tacrolimus [rTAC] versus standard-dose tacrolimus [TAC-C) in de…
  • 2019 American Transplant Congress

    Kidney Xenotransplantation from Genetically Engineered Pigs to Baboons with FDA-Approved Immunosuppressive Therapy

    T. Yamamoto1, H. Hara1, J. Foote1, E. C. Klein2, H. J. Schuurman3, L. Wang1, Q. Li1, H. Zhou1, J. Li1, J. A. Tector1, Z. Zhang2, M. Ezzelarab2, R. Lovingood1, D. Ayares4, D. E. Eckhoff1, D. K. Cooper1, H. Iwase1

    1University of Alabama at Birmingham, Birmingham, AL, 2University of Pittsburgh, Pittsburgh, PA, 3Schubiomed Consultancy, Utrecht, Netherlands, 4Revivicor, Blacksburg, VA

    *Purpose: Genetically-engineered pigs might present a solution to the critical shortage of organs for clinical transplantation. The aims of this study were to evaluate the…
  • 2019 American Transplant Congress

    Improving Medication Adherence and Outcomes in Adult Kidney Transplant Patients Using SystemCHANGETM: Results of the Medication Adherence Given Individual Change (MAGIC) Randomized Clinical Trial

    M. R. Wakefield1, C. M. Ashbaugh2, L. Remy3, D. Aholt3, C. Miller3, S. Ye3, D. K. Hathaway4, D. Clark4, V. S. Staggs5, K. Goggin6, R. J. Ellis7, C. L. Russell3

    1Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, 2Transplant, University of Missouri Health Care, Columbia, MO, 3School of Nursing and Health Studies, University of Missouri-Kansas City, Kansas City, MO, 4College of Nursing, University of Tennessee HSC, Memphis, TN, 5Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, 6Health Services and Outcomes Research, Children's Mercy Kansas City and Schools of Medicine and Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 7School of Nursing, Indiana University, Indianapolis, IN

    *Purpose: Medication non-adherence is an obdurate problem associated with poor outcomes and staggering costs. Even with multi-faceted interventions, effect sizes reported in meta-analyses of medication…
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