2019 American Transplant Congress
CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…2019 American Transplant Congress
A Retrospective Observational Analysis of Tacrolimus Metabolism Rate: No Evidence for Impact on Renal Function
*Purpose: A previous publication found that fast metabolisers of tacrolimus had inferior renal function compared to slow metabolisers in a Caucasian population (Thölking et al.,…2019 American Transplant Congress
Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients
*Purpose: Purpose: Optimal allograft function and long-term graft survival depends on many factors, including adherence to a complex medication regimen. Methods of measuring adherence are…2019 American Transplant Congress
Prevalence of Varicella Zoster Infection in Renal Transplant Recipients
Infectious Diseases, UCLA, Los Angeles, CA
*Purpose: Varicella zoster infection is a serious complication of immunosuppression in renal transplant recipients. We examined the prevalence of VZV infection in renal transplant patients…2019 American Transplant Congress
Combination of Ketoconazole and Tacrolimus Increases the Risk of Kidney Transplant Rejection in African Americans
Nephrology, Tulane University, New Orleans, LA
*Purpose: African American patients generally have a rapid metabolism and thus require higher doses of tacrolimus after kidney transplantation. Ketoconazole inhibits tacrolimus metabolism and can…2019 American Transplant Congress
Use of Eculizumab for Active Antibody-Mediated Rejection That Occurs Early Post-Kidney Transplantation: A Consecutive Series of 15 Cases
*Purpose: Active antibody-mediated rejection (ABMR) that occurs during the amnestic response within the first month post-transplant is a rare but devastating cause of early allograft…2019 American Transplant Congress
Transplant Regimen Adherence For Kidney Recipients By Engaging Information Technologies: The Take It Trial
*Purpose: Several studies report a high prevalence of inadequate adherence to prescribed (Rx) immunosuppressive (IS) medication regimens among kidney transplant (KT) recipients, yet few interventions…2019 American Transplant Congress
Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation
*Purpose: Previous trials have not examined differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx) patients (pts).…2019 American Transplant Congress
Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite
*Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…
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