ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    Comparison of Tacrolimus or Cyclosporine Combined with Methotrexate for Graft versus Host Disease Prophylaxis after Allogeneic Hematopoietic Cell Transplantation: A Meta-Analysis

    M. Chen, B. Huang, Y. Zhang, W. Ju, X. He

    Transplant Center, Sun Yat-sen University, Guangzhou, China

    *Purpose: After patients received hematopoietic stem cell transplantation (HSCT) ,both cyclosporine (CsA) and tacrolimus (TAC) in combination with methotrexate (MTX) have been recommended as standard…
  • 2019 American Transplant Congress

    Efficacy and Safety of Everolimus in Pediatric Renal Transplantation

    T. Sandes-Freitas1, B. Pantoja2, M. Custódio2, A. Goersch Silva3, R. Costa2, M. Sales3, R. Esmeraldo3

    1Hospital Geral de Fortaleza / Federal University of Ceara, Fortaleza, Brazil, 2Federal University of Ceará, Fortaleza, Brazil, 3Hospital Geral de Fortaleza, Fortaleza, Brazil

    *Purpose: There are scarce evidence on the efficacy and safety of everolimus (EVR)-based regimens in pediatric kidney transplantation (KT).*Methods: This single center retrospective cohort analyzed…
  • 2019 American Transplant Congress

    Induction Immunosuppression Practices in Liver Transplantation are Variable and Predict Post-Transplant Survival

    T. Bittermann1, R. Hubbard2, J. Lewis1, D. Goldberg1

    1Gastroenterology, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA

    *Purpose: Unlike in other solid organ transplants, the benefits of induction immunosuppression prior to liver transplantation (LT) remain uncertain. The objective of this study was…
  • 2019 American Transplant Congress

    Determining the Role of Insurance Coverage at the Time of Renal Transplantation as a Predictor of Medication Misadventure

    D. Wilkerson, P. Klem

    Pharmacy, University of Colorado Skaggs School of Pharmacy, Aurora, CO

    *Purpose: To determine if patients who receive financial assistance through the American Kidney Fund (AKF) for health care premiums at the time of transplant are…
  • 2019 American Transplant Congress

    Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation

    T. Tanaka, T. Maehana, N. Masumori

    Department of Urology, Sapporo Medical University, Sapporo, Japan

    *Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…
  • 2019 American Transplant Congress

    Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection

    Z. Zhang1, Q. Liu1, T. Li1, G. S. Hussey2, M. Velayutham1, J. L. Dziki2, L. R. Mathews1, Y. C. Lee2, G. K. Dwyer1, H. Dai1, A. S. Roessing1, S. Shiva3, M. H. Oberbarnscheidt1, S. F. Badylak2, H. R. Turnquist1

    1Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2Department of Bioengineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 3Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Pittsburgh, PA

    *Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…
  • 2019 American Transplant Congress

    Psychosocial Factors and Medication Adherence among Recipients of Vascularized Composite Allografts

    S. Rasmussen1, M. Henderson1, C. Cooney1, J. Shores1, W. Lee1, E. Goldman2, C. Kaufman2, D. Segev1, G. Brandacher1

    1Johns Hopkins University, Baltimore, MD, 2Christine M Kleinert Institute, Louisville, KY

    *Purpose: Psychosocial factors are important predictors of medication adherence, and subsequently graft survival, in solid organ transplantation. Early experiences suggest this may be the case…
  • 2019 American Transplant Congress

    Dosing and Exposure over 2 Years with LCP-Tacrolimus (LCPT) vs. Immediate-Release Tacrolimus (IR-Tac) in De Novo Kidney Transplantation

    K. Budde1, S. Bunnapradist2, S. Patel3, D. Stevens3, U. Meier-Kriesche3, B. Suwelack4

    1Charité University Medicine Berlin, Berlin, Germany, 2UCLA Medical Center, Los Angeles, CA, 3Veloxis Pharmaceuticals Inc, Cary, NC, 4University Hospital of Münster, Münster, Germany

    *Purpose: A prospective study demonstrated safe and efficacious use of LCPT in de novo kidney transplantation. This study aims to evaluate tacrolimus trough levels and…
  • 2019 American Transplant Congress

    Delayed Achievement of Therapeutic Tacrolimus Levels with De Novo Extended-Release Tacrolimus Tablets and the Incidence of Rejection in Kidney Transplant Patients

    C. E. Carthon1, J. C. Hagopian1, S. E. January1, A. Gharabagi1, R. Delos Santos2, T. A. Horwedel3

    1Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, 2Nephrology, Washington University School of Medicine, Saint Louis, MO, 3Veloxis Pharmaceuticals, Inc., Cary, NC

    *Purpose: Early therapeutic tacrolimus levels have been associated with improved outcomes in renal transplant recipients while lower exposure to tacrolimus during the first week of…
  • 2019 American Transplant Congress

    Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

    E. Crespo1, A. Vidal1, A. Sefrin2, P. Fontova1, M. Stein2, H. Volk2, J. Grinyó3, P. Reinke2, N. Lloberas1, O. Bestard3

    1Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, 3Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
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