Articles tagged "Immunosuppression"

2019 American Transplant Congress
Bortezomib Based Induction Therapy Decreases Delayed Graft Function in High Risk Kidney Transplantation
K. Mahendran¹, N. Koizumi², J. K. Melancon¹
¹Transplant Institute, The George Washington University, Washington, DC, ²Schar School of Policy and Government, George Mason University, Arlington, VA
*Purpose: Over 100,000 candidates await a kidney transplant on the national United Network for Organ Sharing (UNOS) waitlist. Among these candidates, one-third have pre-formed antibodies…
2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
2019 American Transplant Congress
A National Survey of Immunosuppression Strategies in Intestinal Transplantation
M. Segovia¹, T. Beduschi², J. Boike³, D. Farmer⁴, S. Horslen⁵, K. Iyer⁶, S. Jafri⁷, A. Langnas⁸, C. Matsumoto⁹, A. Mavis¹, G. Mazariegos¹⁰, S. Nagai⁷, J. O'Leary¹¹, Y. Patel¹, D. Sudan¹, N. Sulejmani⁷, B. Summers⁷, T. Schiano⁶
¹Duke, Durham, NC, ²Univ Miami, Miami, FL, ³NWU, Chicago, IL, ⁴UCLA, Los Angeles, CA, ⁵Seattle Child, Seattle, WA, ⁶Mt Sinai, NY, NY, ⁷Henry Ford, Detroit, MI, ⁸UNMC, Omaha, NE, ⁹Georgetown, Washington, DC, ¹⁰UPMC, Pittsburgh, PA, ¹¹Dallas VAMC, Dallas, TX
*Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
2019 American Transplant Congress
Efficacy of Photobiomodulatory Therapy Combined with Short-Term Immunosuppressants Prolonged Allograft Survival in a Rodent Hind-Limb Model
Y. KUO¹, Y. Li¹, C. Chen¹, R. Chen1¹, G. Brandacher²
¹Division of Plastic Surgery, Department of Surgery,, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ²Department of Plastic Surgery, VCA center, Johns Hopkins University, Baltimore, MD
*Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…
2019 American Transplant Congress
The Effect of a Novel Dosing Protocol for the De Novo Use of LCP Tacrolimus in Kidney Transplant Recipients Managed on a Steroid-Free Maintenance Immunosuppression Regimen
R. Wolff¹, A. Nasstrom¹, C. Borscheid¹, C. Martin¹, A. Temelie¹, R. Spong², D. Keys², T. B. Dunn³
¹School of Pharmacy, MHealth U of MN Medical Center-Fairview, Mpls, MN, ²Medicine, MHealth U of MN Medical Center-Fairview, Mpls, MN, ³Surgery, U of Pennsylvania, Phila, PA
*Purpose: It is not known if an extended release formulation of tacrolimus (LCPT, Envarsus XR®) can be successfully dosed to achieve an early therapeutic trough…
2019 American Transplant Congress
A Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients
T. A. Horwedel¹, C. E. Carthon¹, S. E. January¹, A. Gharabagi¹, R. Delos Santos², J. C. Hagopian¹
¹Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ²Nephrology, Washington University School of Medicine, Saint Louis, MO
*Purpose: Beginning in December 2015, our center instituted a protocol change moving to de novo use of LCPT. The objective of this study is to…
2019 American Transplant Congress
Reduction of Pre-Existing Alloantibodies in Highly Sensitized Belatacept-Treated Kidney Recipients
R. F. Parsons¹, S. Bumb², H. Decker¹, A. Zahid¹, C. Sullivan¹, T. Pearson¹, C. Larsen¹, M. Levine³, M. Kamoun³, R. A. Bray¹, H. M. Gebel¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Cincinnati, Cincinnati, OH, ³University of Pennsylvania, Philadelphia, PA
*Purpose: Recent evidence suggests that belatacept reduces the durability of pre-existing antibodies to class I and class II human leukocyte antigens (HLA). Belatacept has a…
2019 American Transplant Congress
A Novel Apparatus Mimicking Hypertensive Kidney With Primary Cultured Human Kidney Cells Using Rotational Force: Application To In Vitro Drug Screening In Kidney Transplant Recipients
Y. Kim¹, S. Lee², J. Moon¹, J. Kim¹, M. Yu³, C. Lee⁴, Y. Kim¹, S. Yang⁵, J. Jeong¹, J. Seon¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ⁴Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁵Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cell culture is an essential part of the development for various medical technologies such as identifying the cause of the disease and developing new…
2019 American Transplant Congress
Incidence, Risk Factors, Outcomes and Clinical Management of BK Viremia in the Modern Era of Kidney Transplantation
J. Kim
Toronto General Hospital, Toronto, ON, Canada
*Purpose: BK viremia is endemic among kidney transplant recipients (KTR). Previous work has not compared the incidence, risk factors, and outcomes of any vs. clinically…
2019 American Transplant Congress
Immunologic Outcomes In Recipients Of Orthotopic Liver Transplant Induced Only With Steroids
S. N. Merwat, A. T. Chatila, M. Bilal, R. Kulkarni, H. L. Stevenson, J. H. Fair, S. K. Merwat, T. Kozlowski, M. A. Mujtaba
The University of Texas Medical Branch, Galveston, TX
*Purpose: Liver allografts are resistant to antibody mediated rejection (AMR) in the presence of preformed alloantibodies. In most cases donor specific antibodies (DSAs) disappear a…