ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation

    S. Tajima1, R. Fu2, M. Fukuda2, K. Suetsugu2, Y. Okabe3, S. Masuda1

    1Pharmacy, Kyushu University Hospital, Fukuoka, Japan, 2Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 3Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    *Purpose: Biopsy proven acute rejection without clinical symptoms such as subclinical rejection (SCR) is supposed to associate graft loss in the long term post kidney…
  • 2019 American Transplant Congress

    Association between CD19-Positive Rate and Antibody-Mediated Rejection Following Rituximab Administration in Kidney Transplant Recipients

    K. Nanmoku, T. Shinzato, T. Kubo, T. Shimizu, T. Yagisawa

    Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan

    *Purpose: Rituximab, which suppresses antibody production, is widely used for desensitization in ABO-incompatible and donor-specific antibody-positive kidney transplantation. However, data regarding the effects of individual…
  • 2019 American Transplant Congress

    Use of Belatacept in Pancreas Transplantation

    P. D. Uva, A. Quevedo, J. Roses, R. Pilotti, E. Chuluyan, D. Casadei

    Kidney/Pancreas Transplantation, ITAC - Nephrology, Buenos Aires, Argentina

    *Purpose: To review our experience with Belatacept in pancreas transplantation*Methods: Retrospective review including all patients receiving Belatacept after pancreas transplantation. Main objective is to review…
  • 2019 American Transplant Congress

    Comparative Use of Single mTOR vs Dual mTOR/PI3K Inhibition in Regulatory T Cell Expansion for Clinical Application in Transplantation

    R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi

    University of Kentucky, Lexington, KY

    *Purpose: Experimental and pre-clinical evidence suggest that adoptive transfer of regulatory T cells (Tregs) could be an appropriate therapeutic strategy to induce tolerance and improve…
  • 2019 American Transplant Congress

    Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center

    J. S. Kerr, N. Law, S. Aslam

    Center for Transplantation, University of California, San Diego Health System, La Jolla, CA

    *Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…
  • 2019 American Transplant Congress

    Impact of Liver Recipient Genotype on Tacrolimus

    S. Tremblay1, T. Fukuda2, T. Mizuno2, A. A. Vinks2, E. Woodle1, J. Klawitter3, J. Klawitter3, U. Christians3, R. R. Alloway1

    1University of Cincinnati, Cincinnati, OH, 2Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, 3iC42 Clinical Research and Development, Aurora, CO

    *Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
  • 2019 American Transplant Congress

    Is Alemtuzumab Induction Safe In Septuagenarians Undergoing Deceased Donor Kidney Transplantation?

    D. Harriman, V. Gurram, C. Jay, J. Rogers, A. Farney, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, R. Stratta

    Wake Forest Baptist Medical Center, Winston-Salem, NC

    *Purpose: Alemtuzumab induction in septuagenarians is controversial but understudied.*Methods: Single center retrospective review of adult deceased donor kidney transplant (KT) recipients receiving single dose (30…
  • 2019 American Transplant Congress

    CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation

    J. E. Kimpton, A. J. Hughes, I. MacPhee

    Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    *Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
  • 2019 American Transplant Congress

    A Retrospective Observational Analysis of Tacrolimus Metabolism Rate: No Evidence for Impact on Renal Function

    A. J. Hughes, J. E. Kimpton, I. MacPhee

    Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    *Purpose: A previous publication found that fast metabolisers of tacrolimus had inferior renal function compared to slow metabolisers in a Caucasian population (Thölking et al.,…
  • 2019 American Transplant Congress

    Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients

    S. Sullivan1, K. N. Triplett1, C. Sacks2, M. Tran2, D. M. Desai3

    1Solid Organ Transplant, Children's Medical Center, Dallas, Dallas, TX, 2Proteus Digital Health, Redwood City, CA, 3Transplant Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX

    *Purpose: Purpose: Optimal allograft function and long-term graft survival depends on many factors, including adherence to a complex medication regimen. Methods of measuring adherence are…
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