ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    A Low Immuknow Level but Behold….pAMR1(H+) Rejection

    M. W. Weston

    Tampa General Hospital, Tampa, FL

    *Purpose: PURPOSE: The purpose of this study is to evaluate the mechanism of pAMR1(H+) rejection in heart transplant recipients with low ImmuKnow levels (ATP
  • 2022 American Transplant Congress

    Association Between Maintenance Immunosuppressive Regimens And Covid-19 Mortality In Kidney Transplant Recipients

    A. O. Gérard1, S. Barbosa2, D. Anglicheau3, L. Couzi4, M. Hazzan5, O. Thaunat6, G. Blancho7, S. Caillard8, A. Sicard1

    1Nephrology, Nice University Hospital, Nice, France, 2Institute of Molecular and Cellular Pharmacology, CNRS, Valbonne, France, 3Nephrology, Necker University Hospital, APHP, Paris, France, 4Nephrology, Bordeaux Pellegrin University Hospital, Bordeaux, France, 5Nephrology, Lille University Hospital, Lille, France, 6Nephrology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France, 7Nephrology, Nantes University Hospital, Nantes, France, 8Nephrology, Strasbourg University Hospital, Strasbourg, France

    *Purpose: Kidney transplant recipients (KTR) are at increased risk of mortality from COVID-19. We conducted a cohort study among KTR from the French Solid Organ…
  • 2022 American Transplant Congress

    Recurrence of Focal Segmental Glomerulosclerosis After Kidney Transplantation According to Pre-Transplant Treatment

    H. Kwon, S. Shin, Y. Kim

    Department of general surgery, Asan Medical Center, Seoul, Korea, Republic of

    *Purpose: Focal segmental glomerulosclerosis (FSGS) recurrence after kidney transplantation (KT) is a significant risk factor of graft failure. The recurrence of FSGS develops in 30%-60%…
  • 2022 American Transplant Congress

    Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo

    P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, 3Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA

    *Purpose: To determine if IgM has a direct effect in preventing SARS-CoV-2 replication in Vero E6 cells, and delaying or preventing disease in infected K18-hACE2…
  • 2022 American Transplant Congress

    Tacrolimus Exposure Estimation in Stable Kidney Transplant Recipients Using Maximum A Posteriori Bayesian Approach

    T. Nguyen1, N. M. Smith1, K. Attwood2, B. Murray3, K. Tornatore-Morse1

    1University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, 2School of Public Health; University at Buffalo, Buffalo, NY, 3Erie County Medical Center; School of Medicine/UB, Buffalo, NY

    *Purpose: Tacrolimus exhibits interpatient pharmacokinetic variability that impacts clinical responses and requires routine trough therapeutic drug monitoring. Tacrolimus troughs do not consistently predict area under…
  • 2022 American Transplant Congress

    Management and Outcomes of Coronavirus Disease 2019 in Solid Organ Transplant Recipients

    A. Scott, Z. Truman, M. Manson

    Baylor St. Luke's Medical Center, Houston, TX

    *Purpose: The purpose of this study was to assess treatment of coronavirus disease 2019 (COVID-19) and immunosuppression modification in solid organ transplant (SOT) recipients, and…
  • 2022 American Transplant Congress

    Improvement in Kidney Function After Early Conversion to Belatacept-Based Regimen in Allografts with Biopsy-Proven Donor Vascular Disease

    T. Ommert1, J. Javier1, J. Jackson1, C. Klein2

    1Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA, 2Piedmont Transplant Institute, Atlanta, GA

    *Purpose: Donor arteriosclerosis in the kidney allograft predicts poorer graft outcomes and is a risk factor for tacrolimus-induced nephrotoxicity. Belatacept conversion has been utilized as…
  • 2022 American Transplant Congress

    The Impact of Maintenance Immunosuppressive Regimen on COVID-19 Outcomes Among Kidney Transplant Patients

    T. V. Sandes-Freitas1, L. Modelli de Andrade2, L. Requião-Moura3, J. Medina-Pestana3, H. Tedesco-Silva3, A. on behalf of Covid-19 KT Brazil Study Group1

    1Universidade Federal do Ceará / Unidade Pesquisa Clínica CH-UFC/EBSERH, Fortaleza, Brazil, 2Universidade Estadual Paulista - UNESP, Botucatu, Brazil, 3Universidade Federal de São Paulo / Hospital do Rim, São Paulo, Brazil

    *Purpose: Compared to azathioprine (AZA), mycophenolate (MPA) is implicated in an increased risk of several viral infections. Contrariwise, mTOR inhibitors (mTORi) are protective. Therefore, the…
  • 2022 American Transplant Congress

    Risk of Post-Transplant Lymphoproliferative Disease After Anti-Thymocyte Globulin in Childhood Solid-Organ Transplant Recipients

    A. M. McKay1, C. Teoh1, J. Vasilevska-Ristovka2, J. Browne2, T. Banh2, A. Dipchand1, V. Ng1, M. Solomon1, U. Allen1, Y. Avitzur1, R. Parekh3

    1Transplant & Regenerative Medicine Centre, The Hospital for Sick Children, Toronto, ON, Canada, 2Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 3Division of Nephrology, Department of Medicine, Women’s College Hospital and University Health Network, Toronto, ON, Canada

    *Purpose: Determine if the use of anti-thymocyte globulin (ATG) in pediatric solid organ transplant recipients was associated with an increased risk of post-transplant lymphoproliferative disorder…
  • 2022 American Transplant Congress

    Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes

    M. Nunez1, S. Wisel2, J. Gardner3, G. Worner4, G. Roll5, S. Syed3, G. Szot1, M. Tavakol1, K. Johnson1, A. Posselt4, P. Stock6

    1Surgery, University of California, San Francisco, San Francisco, CA, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3University of California, San Francisco, San Francisco, CA, 4University of California San Francisco, San Francisco, CA, 5UCSF Medical Center, San Francisco, CA, 6Univ of California-San Francisco, San Francisco, CA

    *Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…
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