Articles tagged "Immunosuppression"

2020 American Transplant Congress
PD-L1 Signals Lymphatic Endothelium for Treg Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena³, Y. Xiong¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar², L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²Pediatrics, U of Minnesota, Minneapolis, MN, ³U of Maryland, Baltimore, MD, ⁴Transplantation Research Center, Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
2020 American Transplant Congress
Early Corticosteroid Withdrawal in Pancreas and Simultaneous Pancreas-Kidney Transplant Recipients: Long-Term Clinical and Metabolic Outcomes of from a Single Center Retrospective Cohort
A. Lichvar, L. Lin, Y. Chen, Y. Yen, D. Pierce, A. Nadeem, P. West-Thielke, I. Tang, J. Almario, M. Spaggiari, I. Tzvetanov, E. Benedetti, M. Campara
University of Illinois at Chicago, Chicago, IL
*Purpose: Tacrolimus, mycophenolate mofetil, and chronic corticosteroids (CCS) are the most popular immunosuppression regimen after pancreas transplantation. Early corticosteroid withdrawal (ECSWD) is an increasingly popular…
2020 American Transplant Congress
Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation
B. I. Shaw¹, H. Lee², C. Chan², R. B. Ettenger³, P. Grimm⁴, E. F. Reed⁵, M. Sarwal⁶, L. Stempora¹, B. Warshaw⁷, O. M. Martinez⁸, A. D. Kirk¹, E. T. Chambers⁹
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, University of California, Los Angeles, Los Angeles, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Pathology, University of California, Los Angeles, Los Angeles, CA, ⁶Surgery, University of California, San Francisco, San Francisco, CA, ⁷Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA, ⁸Surgery, Stanford University, Palo Alto, CA, ⁹Pediatrics, Duke University, Durham, NC
*Purpose: Nutritional status is known to modulate immunologic responses in non-immunosuppressed individuals. We utilized the Immune Development in Pediatric Transplantation (IMPACT) study to assess differences…
2020 American Transplant Congress
Reactivation of Murine Polyomavirus Replication by Renal Ischemia-Reperfusion Injury and Immunosuppression
G. Huang¹, Y. Huang¹, X. Chen¹, J. Qiu¹, J. Li¹, G. Li², C. Wang¹, L. Chen¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Guangdong Key Laboratory of Laboratory Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China
*Purpose: Polyomavirus (PyV) nephropathy is an important cause of graft failure after renal transplantation. Its pathogenesis is associated with immunosuppression (IM) and renal ischemia-reperfusion injury…
2020 American Transplant Congress
New Everolimus Administration Targeting the Prevention of the Development of Antibody-Mediated Rejection Considering the Comparison of Growth and Survival in IgG and IgM Memory B Cells
Y. Matsuda¹, R. Imamura¹, H. Tezuka², S. Takahara¹
¹Osaka University Graduate School of Medicine, Suita, Japan, ²Fujita Health University, Toyoake, Japan
*Purpose: Some reports indicated that immunoglobulin (Ig) M antibodies corresponding to donor-specific antigen in addition to IgG antibodies are closely involved in the activation of…
2020 American Transplant Congress
Mycophenolate Mofetil and the Incidence of Skin Cancer in Kidney Transplant Recipients
S. J. Yusuf¹, H. Bheemreddy¹, A. Imtiaz², N. Krishnan³
¹Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom, ²Dermatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ³Renal Unit, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
*Purpose: Over the years there has been a shift in the use of anti-metabolites agents from azathioprine to mycophenolate mofetil (MMF) based immunosuppression., due to…
2020 American Transplant Congress
Myeloid Derived Suppressor Cells Expanded by Granulocyte-Colony Stimulating Factor Prolong Allogeneic Cardiac Graft Survival When Compared with MDSCs Expanded by Different Means
Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSCs) inhibit T cell responses and may provide a pathway towards tolerance. Granulocyte-colony stimulating factor (GCSF) is used in clinical practice…
2020 American Transplant Congress
Everolimus for BKV Nephropathy in Kidney Transplant Recipients: A Prospective, Controlled Study
E. Bussalino¹, D. Bellino¹, L. Marsano¹, F. Massarino¹, R. Russo¹, I. Fontana², G. Zaza³, G. Stallone⁴, E. Paoletti¹
¹Nephrology, Dialysis, and Transplantation, Policlinico San Martino Genova, Genova, Italy, ²Transplantation Unit, Policlinico San Martino Genova, Genova, Italy, ³Renal Unit, Department of Medicine,, University Hospital of Verona, Verona, Italy, ⁴Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
*Purpose: Polyoma BK virus nephropathy (BKVN) of KTRs is associated with adverse outcome, since no specific therapy exists. EVR showed promising antiviral effects but systematic…
2020 American Transplant Congress
Introduction of Preemptive Pharmacogenomic Testing in Kidney Transplant Recipients: Early Evaluation of the Clinical Impact of Genomic Guided Tacrolimus Dosing
G. Girone¹, V. Do¹, K. Belfield¹, R. Pulk¹, E. Cohen¹, E. Marin²
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Department of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Tacrolimus is widely accepted as the mainstay of immunosuppression in solid organ transplant. Inherited differences in CYP3A activity are known to contribute to dosing…
2020 American Transplant Congress
Patient and Renal Outcomes of Post Transplant Lymphoproliferative Disorder Following Solid Organ Transplantations – A Single Center Experience
G. Katz-Greenberg¹, K. Mallari², U. Martinez-Outschoorn¹, M. P. MartinezCantarin¹
¹Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, ²Thomas Jefferson University, Philadelphia, PA
*Purpose: Posttransplant lymphoproliferative disorder (PTLD) remains an unfortunate complication in patients following solid organ transplantation (SOT) and hematopoietic stem cells transplantations. The diagnosis of PTLD…