Articles tagged "Immunosuppression"

2020 American Transplant Congress
Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival
A. K. Singh, C. Goerlich, G. Braileanu, A. Hersfield, T. Zhang, I. Tatarov, B. Lewis, F. Sentz, D. Ayares, K. Horvath, D. Kaczorowski, B. Griffith, M. M. Mohiuddin
Department of Surgery, University of Maryland Baltimore, Baltimore, MD
*Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…
2020 American Transplant Congress
Late De Novo Donor Specific Antibodies in Steroid Free Immunosuppression and Delayed Graft Function
S. Karhadkar, M. Falz, A. Diamond, A. Di Carlo, O. Timofeeva
Temple University School of Medicine, Philadelphia, PA
*Purpose: Donor Specific Antibodies (DSA) have been implicated in acute and chronic antibody-mediated rejection. Once developed, they tend to be persistent and lead to transplant…
2020 American Transplant Congress
Implementation of a Pharmacist in an Adult Transplant Outpatient Clinic (Kidney, Liver, Pancreas): A Pilot Study – Implant
P. Leveille-Dugas¹, C. Bernard¹, L. Loiselle¹, Y. Zhang¹, C. Coursol¹, K. Mousseau¹, N. Sheehan¹, M. Cantarovich²
¹Pharmacy, McGill University Health Centre, Montréal, QC, Canada, ²Division of Nephrology, Department of Medicine, McGill University Health Centre, Montréal, QC, Canada
*Purpose: Solid organ transplant (SOT) patients require a complex medication regimen which increases the risk of many drug-related problems. The purpose of this study was…
2020 American Transplant Congress
Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience
K. Bowers¹, V. M. Panzarino¹, A. Campos¹, J. Buggs², V. D. Bowers²
¹Pediatrics, USF, Tampa, FL, ²Transplant Surgery, TGH, Tampa, FL
*Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
2020 American Transplant Congress
Improved Kidney Function Post Lung Transplant with Intravenous Tacrolimus Avoidance
C. Burt¹, A. Feist¹, K. Afshar², L. Awdishu¹, M. Mariski¹, J. Kozuch¹, G. Yung², E. Golts³
¹Pharmacy, UC San Diego Health, San Diego, CA, ²Pulmonology, UC San Diego Health, San Diego, CA, ³Cardiothoracic Surgery, UC San Diego Health, San Diego, CA
*Purpose: Tacrolimus (TAC) poses a dose-dependent risk of acute kidney injury (AKI) as well as chronic kidney disease (CKD) post-transplant. In 2017, our institution’s lung…
2020 American Transplant Congress
Risk Factors for the Development of Avascular Necrosis: Single Center Experience
A. Karakok¹, A. Velioglu², I. H. Arikan², E. Asicioğlu², S. Tuglular¹
¹Marmara University School of Medicine, Istanbul, Turkey, ²Nephrology, Marmara University School of Medicine, Istanbul, Turkey
*Purpose: Avascular necrosis (AVN) is one of the most common bone complications after kidney transplantation. In recent years, it has become an important morbidity with…
2020 American Transplant Congress
A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection
A. Komin¹, C. Liang², P. Majumder², X. Calderon-Colon³, O. Tiburzi³, M. Iglesias Lozano¹, Y. Zhang¹, G. Brandacher¹, J. Patrone³, J. Schneider², G. Raimondi¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²NIH National Cancer Institute, Frederick, MD, ³JHU Applied Physics Laboratory, Laurel, MD
*Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…
2020 American Transplant Congress
Tolerant Liver Transplant Patients Have Higher Level of Y RNA Fragments in the Circulation
C. Kuscu¹, A. Wolen¹, A. Bajwa¹, C. Kuscu¹, J. Eason², B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Tolerance post transplantation continue to be the ultimate goal in transplantation. Circulating small RNAs are one of the best candidates for biomarker studies. To…
2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…