Articles tagged "Immunosuppression"

2020 American Transplant Congress
Belatacept in Kidney Transplant Recipients with Previous Non-Renal Solid Organ Transplants
O. Cristea, C. Larsen, I. Badell
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Selective co-stimulatory blockade with belatacept has demonstrated long-term benefits in renal transplantation, with improved glomerular filtration rate and decreased risk of death and graft…
2020 American Transplant Congress
Novel Mechanism of Immune Evasion by Human Neonatal Cardiac Progenitor Cells Recovers Ailing Myocardium in Rat Myocardial Infarct Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, L. Davidson, X. Fu, A. Shah, M. Abdullah, D. Li, S. Kaushal
Surgery, University of Maryland, Baltimore, MD
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal cardiac progenitor cells…
2020 American Transplant Congress
Conversion to a Belatacept Based Immunosuppression Regimen in Renal Transplant Recipients
K. Paplaczyk, K. Cunningham, C. D'Agostino, D. Pinelli, J. Schulte, A. Shetty
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Belatacept, a co-stimulation blocker, is an alternative anti-rejection agent that may avoid nephrotoxic or intolerable adverse effects of calcineurin inhibitor (CNI) or mammalian target…
2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
P. Cravedi, M. Fribourg, S. Harztell, L. Anderson, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
2020 American Transplant Congress
Thymoglobulin for Induction Less is Clearly More!
N. Patel, P. Nicole
-, -, SC
*Purpose: The ideal total dose of anti-thymocyte globulin (ATG) is unknown in the African American (AA) kidney transplant population.The purpose of this study was to…
2020 American Transplant Congress
Comparison of Clinical Outcomes of Induction Regimens in Patients Undergoing Liver Transplantation for Acute Liver Failure
C. M. Anugwom¹, J. Parekh², C. Hwang³, M. MacConmara³, W. M. Lee⁴, T. M. Leventhal¹
¹Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical Center, Minneapolis, MN, ²Department of Surgery, University of California, San Diego, San Diego, CA, ³Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Spontaneous survival rates in acute liver failure (ALF) are vastly improved by liver transplantation (LT). However, the value of induction agents beyond steroids continues…
2020 American Transplant Congress
Yield and Utility of Surveillance Kidney Biopsies in Pediatric Kidney Transplant Recipients at Various Time Points Post-Transplant
A. Landsberg¹, M. Riazy², T. Blydt-Hansen¹
¹Nephrology, BC Children's Hospital, Vancouver, BC, Canada, ²Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada
*Purpose: There lacks consensus regarding the appropriate timing of routine surveillance biopsies (SB) for pediatric kidney transplant recipients. We evaluated the yield of positive biopsy…
2020 American Transplant Congress
Outcomes of Intra-Operative Steroid Induction in Liver Transplant Recipients
A. Poparad-Stezar, A. Jantz, T. Larson, B. Summers, N. Sulejmani
Henry Ford Hospital, Detroit, MI
*Purpose: Evidence supporting the use of antibody induction (AI) immunosuppression (IS) (antithymocyteglobulin (rATG) and basiliximab (BAS)) for acute rejection (AR) prophylaxis in liver transplant is…
2020 American Transplant Congress
Oral versus Intravenous Mycophenolate Mofetil Administration: A Single Center Experience on Incidence of Acute Kidney Injury
P. Chung¹, K. Forrester², S. Ganesh¹
¹Division of Pulmonary Critical and Sleep Medicine, University of Southern California, Los Angeles, CA, ²Department of Clinical Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA
*Purpose: Mycophenolate mofetil (MMF) is one of the main immunosuppressive medications given in lung transplantation (LTx). It is given orally (PO) or intravenously (IV). In…