2020 American Transplant Congress
Effect of Maintaining Immunosuppression after Kidney Graft Failure on Mortality and Re-Transplantation
*Purpose: Patients with a failed renal allograft are at high risk for mortality. The potential benefit of maintaining immunosuppression with the intent to minimize sensitization…2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…2020 American Transplant Congress
Adult Primary Liver Transplant Recipient Outcomes by Immunosuppression Induction Received
*Purpose: It has long been recognized that the highest risk of rejection of an organ is in the first few months post transplantation. To prevent…2020 American Transplant Congress
Transplant Relevant MDSC Genetics: Differential Gene Expression Profiles of Immunosuppressive Myeloid-Derived Suppressor Cells Induced by Granulocyte-Colony Stimulating Factor
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are expanded in inflammation conditions and can control alloreactive T cell responses. Granulocyte-colony stimulating factor (GCSF) is known to induce…2020 American Transplant Congress
Stanford Integrated Psychosocial Assessment for Transplant Predicts Immunosuppression Non-Adherence after Liver Transplantation
*Purpose: Patients with end-stage liver disease presenting for liver transplant (LT) evaluation have a high burden of psychosocial comorbidities. The Stanford Integrated Psychosocial Assessment for…2020 American Transplant Congress
Remote Steroid Wean is Safe When Compared to Early Wean in Heart Transplant Recipients
Cardiovascular Disease, Heart Failure and Transplant, Houston Methodist Hospital, Houston, TX
*Purpose: The risks and benefits of remote steroid wean in heart transplant recipients is unknown. We compared outcomes in patients undergoing early and remote steroid…2020 American Transplant Congress
Sirolimus Combined with Low-Dose Calcineurin Inhibitor in Kidney Transplant Recipients from Expanded Criteria Donors
Beijing Friendship Hospital, Capital Medical University, Beijing, China
*Purpose: To evaluate the efficacy and safety of conversion from calcineurin inhibitor-based immunosuppressive regimen to sirolimus combined with low-dose calcineurin inhibitor in recipients with abnormal…2020 American Transplant Congress
T Cell Hyporesponsiveness in Kidney Transplant Recipients is Associated with Urinary Tract Infections and Age of Kidney Transplant: Implications for Allograft Nephropathy
Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa
*Purpose: Chronic allograft nephropathy is the main cause of kidney graft loss. With the use of potent immunosuppressive treatments, acute rejections are less and less…2020 American Transplant Congress
Conversion to Belatacept (BLT)- from Calcineurin Inhibitor (CNI)-Based Immunosuppression During the First Year Post-Transplant (<1yr Tx) Increases Risk for CMV Infection Through Inhibition of Anti-CMV Humoral Immunity
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have shown a higer CMV infection rate in kidney Tx patients (KTx Pts) who were converted to BLT 1yr post-Tx. Viral infections are…2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
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