Articles tagged "Immunosuppression"

2022 American Transplant Congress
A Single Center Experience of Simultaneous Heart-Kidney Transplantation
A. Samra¹, A. Mattoo²
¹Nephrology, New York University Langone Transplant Institute, New York, NY, ²New York University Langone Transplant Institute, New York, NY
*Purpose: Currently there are no UNOS guidelines regarding the selection criteria required for simultaneous heart-kidney transplant recipients (SHKT). As of 2018 our center has begun…
2022 American Transplant Congress
Five-Year Follow-Up from a Prospective, Randomized Trial of Belatacept-Based, CNI Free/Early Steroid Withdrawal Regimens
H. Hames¹, A. R. Shields¹, E. Yanqui¹, A. Christianson¹, J. Kremer², A. Govil¹, E. S. Woodle¹, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²Christ Hospital, Cincinnati, OH
*Purpose: A prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based, calcineurin inhibitor-free (CNI), early corticosteroid withdrawal (ESW) regimens with a tacrolimus (TAC)-based ESW…
2022 American Transplant Congress
Synergistic Effect of CXCR5⁺CD8⁺ T_Ab-supp Cell Adoptive Cell Therapy and mTOR Inhibition (but Not Calcineurin Inhibition) in Suppressing Alloantibody Following Kidney Transplant in Mice
J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹
¹Dept. of Surgery, The Ohio State University, Columbus, OH, ²Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH
*Purpose: We have reported that CXCR5+CD8+TAb-supp cells mediate suppression of alloantibody (alloAb) production and prolong graft survival in both hepatocellular and kidney transplant (KTx) mouse…
2022 American Transplant Congress
Kidney Transplant Recipients with Diabetic Mellitus Demand Larger Doses of Mycophenolate Mofetil
D. Takamoto, H. Sasaki, S. Harada, Y. Takada, H. Harada, T. Tsujimoto
Kidney transplant surgery and Urology, Sapporo City General Hospital, Sapporo, Japan
*Purpose: To monitor blood concentration of immunosuppressants, therapeutic drug monitoring (TDM) is required at any point after kidney transplantation (KT) to prevent kidney graft from…
2022 American Transplant Congress
Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation
N. Fujiyama¹, M. Saito², R. Yamamoto², R. Sagehashi², T. Saito², Y. Aoyama², K. Numakura², T. Habuchi², S. Satoh¹
¹Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, ²Department of Urology, Akita University Graduate School of Medicine, Akita, Japan
*Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
2022 American Transplant Congress
A Dose Dependent Effect of Varying Tacrolimus Concentrations on Cytomegalovirus Viral Specific T Cell Interferon Gamma Expression
H. L. Kleiboeker¹, M. R. Jorgenson¹, R. O. Meyers², O. Ganz², S. Parajuli³, J. Galipeau⁴
¹Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, ²Program for Advanced Cell Therapy, University of Wisconsin Hospital and Clinics and School of Medicine and Public Health, Madison, WI, ³Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Medicine, Division of Hematology and Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Tacrolimus, considered the backbone of transplant immunosuppression, is associated with increased risk of viral infections, including cytomegalovirus (CMV), due to its potent inhibitory effect…
2022 American Transplant Congress
Ex Vivo Modification of Vascular Allografts Using Immunosuppressive and Anti-Inflammatory Polymers Prevent Rejection via Localized Immunosuppression
H. D. Luo¹, E. M. Siren¹, W. Enns², L. Sim¹, C. Du¹, S. G. Withers¹, J. Choy³, J. N. Kizhakkedathu¹
¹The University of British Columbia, Vancouver, BC, Canada, ²Simon Fraser University, Burnaby, BC, Canada, ³Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
*Purpose: Classical immunosuppressants lead to systemic immune shutdown, though necessary to mediate transplant rejection, it may lead to various complications. To reduce off-target immunosuppression while…
2022 American Transplant Congress
Clinical Characteristics Of Serologic Non-responders To Covid-19 Booster Vaccination In A Cohort Of Solid Organ Transplant Recipients.
F. N. Zervou¹, K. Khalil¹, T. Lao¹, D. Wood², S. Jonche¹, A. Mattoo¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²New York University Langone Health, Brooklyn, NY
*Purpose: The purpose of this study was to assess the clinical characteristics of serologic non-responders to COVID-19 booster vaccination in a cohort of solid organ…
2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
C. M. Darden¹, S. Vasu², J. Mattke³, Y. Liu², B. Naziruddin⁴, M. C. Lawrence²
¹Baylor University, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
2022 American Transplant Congress
Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs
J. Wu, F. Zhang, W. Wang
Beijing Chaoyang Hospital, Beijing, China
*Purpose: The occurrence of acute and chronic rejections after transplantation are key factors that affect the survival of the recipients. Induction of transplantation immune tolerance…