Articles tagged "Immunosuppression"

2022 American Transplant Congress
Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations
S. Fredrick¹, B. Wise², L. Bowman², D. DeWolfe¹, J. Taylor¹, J. Melaragno¹
¹University of Rochester Medical Center, Rochester, NY, ²Tampa General Hospital, Tampa, FL
*Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…
2022 American Transplant Congress
Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients
J. Mitchell¹, T. P. Chiang¹, J. Alejo¹, A. Chang¹, A. Abedon¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin-Madison, Madison, WI
*Purpose: Mycophenolate mofetil (MMF) use is associated with decreased antibody response to the SARS-CoV-2 mRNA vaccine series in heart and lung transplant recipients (HLTRs). Higher…
2022 American Transplant Congress
Intensive Antimetabolite Reduction is Not Associated with Increased Risk of Biopsy-Proven Acute Rejection in Kidney Transplant Recipients with BK Virus Infection; a Single Center Experience
J. Marvin¹, D. Malhotra², P. Jethwani², K. Belfield¹, E. Cohen¹
¹Yale New Haven Hospital, New Haven, CT, ²Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Polyoma BK virus (BKV) is a ubiquitous DNA virus that is capable of reactivation and infection in kidney transplant recipients (KTR). Manifestations of the…
2022 American Transplant Congress
Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function
I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta
University of Kansas Medical Center (KUMC), Kansas City, KS
*Purpose: To assess if switching to extended release (ER) tacrolimus changes cerebral blood flow (CBF) or cognitive function after switching stable kidney transplant (KT) recipients…
2022 American Transplant Congress
Conversion to Belatacept for Calcineurin Inhibitor Toxicities
S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew
Columbia University Medical Center, New York, NY
*Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴
¹Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ³Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
2022 American Transplant Congress
How Does Anti-CD38 Antibody Treatment (Daratumumab) Impact Immunological Assessment in Solid Organ Transplantation?
S. Ho¹, K. Putnam², C. Peiter², W. Herczyk², J. Gerlach³, E. Campagnaro⁴, Y. Lu⁴, K. Woodside⁴, M. Cusick⁴
¹Gift of Hope Organ & Tissue Donor Network, Itasca, IL, ²Gift of Life Michigan, Ann Arbor, MI, ³Michigan State University, East Lansing, MI, ⁴University of Michigan Medicine, Ann Arbor, MI
*Purpose: We report the first case of Dara interference of routine pre-transplant (Tx) crossmatch (XM) repeatedly causing aberrant false positives which inadvertently delayed Tx for…
2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2022 American Transplant Congress
Is a Single Dose of Steroids in Adult Living Donor Liver Transplant Safe? – A Cohort Analysis
M. Nunez, C. Praglin, A. M. Torres, E. Agudelo, H. Braun, C. Huang, S. Syed, J. Roberts, G. Roll
University of California San Francisco, San Francisco, CA
*Purpose: Steroids increase morbidity, and steroid avoidance (SA) has been studied in deceased donor liver transplant but, little is known about SA in living donor…
2022 American Transplant Congress
PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², J. He², Y. Guo², B. Oh², G. Brandacher², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…